Department of Plastic and Reconstructive Surgery
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The immune response is initiated by dendritic cells via interaction with microorganisms and interleukin-2 production.
The Journal of infectious diseases Jun, 2003 | Pubmed ID: 12792850
Dendritic cells,tolerance and therapy of organ allograft rejection.
Contributions to nephrology , 2005 | Pubmed ID: 15567925
Low TLR4 expression by liver dendritic cells correlates with reduced capacity to activate allogeneic T cells in response to endotoxin.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2005 | Pubmed ID: 15699133
Regulated compartmentalization of programmed cell death-1 discriminates CD4+CD25+ resting regulatory T cells from activated T cells.
Journal of immunology (Baltimore, Md. : 1950) Mar, 2006 | Pubmed ID: 16493037
Induction of peripheral T cell tolerance by antigen-presenting B cells. I. Relevance of antigen presentation persistence.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16547236
Induction of peripheral T cell tolerance by antigen-presenting B cells. II. Chronic antigen presentation overrules antigen-presenting B cell activation.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2006 | Pubmed ID: 16547237
Endotoxin modulates the capacity of CpG-activated liver myeloid DC to direct Th1-type responses.
European journal of immunology Sep, 2006 | Pubmed ID: 16917958
"Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3+CD4+ T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2006 | Pubmed ID: 17056511
Naturally occurring regulatory T cells: recent insights in health and disease.
Critical reviews in immunology , 2007 | Pubmed ID: 17430097
Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4+ T cells, but enrich for antigen-specific Foxp3+ T regulatory cells and promote organ transplant tolerance.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2007 | Pubmed ID: 17513751
Frontiers of immunological tolerance.
Methods in molecular biology (Clifton, N.J.) , 2007 | Pubmed ID: 17876084
Rapamycin-conditioned, alloantigen-pulsed dendritic cells promote indefinite survival of vascularized skin allografts in association with T regulatory cell expansion.
Transplant immunology Feb, 2008 | Pubmed ID: 18158116
High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance.
Transplantation Feb, 2008 | Pubmed ID: 18301333
Poor allostimulatory function of liver plasmacytoid DC is associated with pro-apoptotic activity, dependent on regulatory T cells.
Journal of hepatology Dec, 2008 | Pubmed ID: 18926588
Immunoregulatory functions of mTOR inhibition.
Nature reviews. Immunology May, 2009 | Pubmed ID: 19390566
Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance.
Transplantation May, 2009 | Pubmed ID: 19424018
Rhesus monkey immature monocyte-derived dendritic cells generate alloantigen-specific regulatory T cells from circulating CD4+CD127-/lo T cells.
Transplantation Nov, 2009 | Pubmed ID: 19898200
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients.
Journal of immunology (Baltimore, Md. : 1950) Jan, 2010 | Pubmed ID: 20007530
Non-human primate regulatory T cells: current biology and implications for transplantation.
Transplantation Oct, 2010 | Pubmed ID: 20671597
Controlled release formulations of IL-2, TGF-β1 and rapamycin for the induction of regulatory T cells.
Journal of controlled release : official journal of the Controlled Release Society Apr, 2012 | Pubmed ID: 22285546
Induced regulatory T cells: mechanisms of conversion and suppressive potential.
Human immunology Apr, 2012 | Pubmed ID: 22285847
Selective expansion of allogeneic regulatory T cells by hepatic stellate cells: role of endotoxin and implications for allograft tolerance.
Journal of immunology (Baltimore, Md. : 1950) Apr, 2012 | Pubmed ID: 22427640
IL-27 production and STAT3-dependent upregulation of B7-H1 mediate immune regulatory functions of liver plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) Jun, 2012 | Pubmed ID: 22508931
Migratory, and not lymphoid-resident, dendritic cells maintain peripheral self-tolerance and prevent autoimmunity via induction of iTreg cells.
Blood Aug, 2012 | Pubmed ID: 22760781
Bioinspired controlled release of CCL22 recruits regulatory T cells in vivo.
Advanced materials (Deerfield Beach, Fla.) Sep, 2012 | Pubmed ID: 22821823
Human induced pluripotent stem cell-derived models to investigate human cytomegalovirus infection in neural cells.
PloS one , 2012 | Pubmed ID: 23209593
All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities.
Journal of leukocyte biology Nov, 2013 | Pubmed ID: 23898044
Persistent infection by HSV-1 is associated with changes in functional architecture of iPSC-derived neurons and brain activation patterns underlying working memory performance.
Schizophrenia bulletin Jan, 2015 | Pubmed ID: 24622295
Donor age negatively affects the immunoregulatory properties of both adipose and bone marrow derived mesenchymal stem cells.
Transplant immunology May, 2014 | Pubmed ID: 24632513
Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance.
Immunotherapy , 2014 | Pubmed ID: 24896631
The use of luminex assays to measure cytokines.
The Journal of investigative dermatology Apr, 2015 | Pubmed ID: 25785953
Abstract 11: the role of donor antigen persistance in maintaining immune tolerance to a vascularized composite allograft.
Plastic and reconstructive surgery Mar, 2014 | Pubmed ID: 25942122
Abstract 102: inflammatory mediators modulate alloreactive T cell susceptibility to immune-regulation in reconstructive transplantation.
Plastic and reconstructive surgery Mar, 2014 | Pubmed ID: 25942213
Exploring cell-based tolerance strategies for hand and face transplantation.
Expert review of clinical immunology Aug, 2015 | Pubmed ID: 26271821
Exploring cell-based tolerance strategies for hand and face transplantation.
Expert review of clinical immunology Nov, 2015 | Pubmed ID: 26289376
Georg J. Furtmüller*,1,
Byoungchol Oh*,1,
Johanna Grahammer*,2,
Cheng-Hung Lin3,
Robert Sucher4,
Madeline L. Fryer1,
Giorgio Raimondi1,
W.P. Andrew Lee1,
Gerald Brandacher1
1Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation (VCA) Laboratory, Johns Hopkins University School of Medicine,
2Department of Visceral, Transplant and Thoracic Surgery, Innsbruck Medical University,
3Center for Vascularized Composite Allotransplantation, Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital and School of Medicine,
4Department of General, Visceral and Transplant Surgery, Charite Berlin