Skeletal Biotech Laboratory
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The T-box transcription factor Brachyury mediates cartilage development in mesenchymal stem cell line C3H10T1/2.
Journal of cell science Feb, 2002 | Pubmed ID: 11865033
Systemically administered rhBMP-2 promotes MSC activity and reverses bone and cartilage loss in osteopenic mice.
Journal of cellular biochemistry , 2002 | Pubmed ID: 12210753
Cell-mediated gene therapy for bone formation and regeneration.
Current opinion in molecular therapeutics Aug, 2002 | Pubmed ID: 12222877
Estrogens activate bone morphogenetic protein-2 gene transcription in mouse mesenchymal stem cells.
Molecular endocrinology (Baltimore, Md.) Jan, 2003 | Pubmed ID: 12511606
Molecular imaging of the skeleton: quantitative real-time bioluminescence monitoring gene expression in bone repair and development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Mar, 2003 | Pubmed ID: 12619943
Short-term BMP-2 expression is sufficient for in vivo osteochondral differentiation of mesenchymal stem cells.
Stem cells (Dayton, Ohio) , 2004 | Pubmed ID: 14688393
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation.
Blood Apr, 2004 | Pubmed ID: 15070669
Gene therapy platform for bone regeneration using an exogenously regulated, AAV-2-based gene expression system.
Molecular therapy : the journal of the American Society of Gene Therapy Apr, 2004 | Pubmed ID: 15093189
Distinct roles of BMP receptors Type IA and IB in osteo-/chondrogenic differentiation in mesenchymal progenitors (C3H10T1/2).
BioFactors (Oxford, England) , 2004 | Pubmed ID: 15322331
Murine spinal fusion induced by engineered mesenchymal stem cells that conditionally express bone morphogenetic protein-2.
Journal of neurosurgery. Spine Jul, 2005 | Pubmed ID: 16122022
Structural and nanoindentation studies of stem cell-based tissue-engineered bone.
Journal of biomechanics , 2007 | Pubmed ID: 16524583
Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells.
The Journal of clinical investigation Apr, 2006 | Pubmed ID: 16585960
Osteogenic differentiation of noncultured immunoisolated bone marrow-derived CD105+ cells.
Stem cells (Dayton, Ohio) Jul, 2006 | Pubmed ID: 16601078
Nucleofection-based ex vivo nonviral gene delivery to human stem cells as a platform for tissue regeneration.
Tissue engineering Apr, 2006 | Pubmed ID: 16674300
Advanced molecular profiling in vivo detects novel function of dickkopf-3 in the regulation of bone formation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Dec, 2006 | Pubmed ID: 17002559
Circadian oscillation of gene expression in murine calvarial bone.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Mar, 2007 | Pubmed ID: 17144790
Endoscopic cellular microscopy for in vivo biomechanical assessment of tendon function.
Journal of biomedical optics Nov-Dec, 2006 | Pubmed ID: 17212533
Review: gene- and stem cell-based therapeutics for bone regeneration and repair.
Tissue engineering Jun, 2007 | Pubmed ID: 17516852
Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering.
Tissue engineering Mar, 2007 | Pubmed ID: 17518596
Design of a filamentous polymeric scaffold for in vivo guided angiogenesis.
Tissue engineering Nov, 2006 | Pubmed ID: 17518618
Evidence for skeletal progenitor cells in the degenerate human intervertebral disc.
Spine Nov, 2007 | Pubmed ID: 17978651
Fluorescence molecular tomography enables in vivo visualization and quantification of nonunion fracture repair induced by genetically engineered mesenchymal stem cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Apr, 2008 | Pubmed ID: 17985393
Nonvirally engineered porcine adipose tissue-derived stem cells: use in posterior spinal fusion.
Stem cells (Dayton, Ohio) Apr, 2008 | Pubmed ID: 18218819
Molecular targets for tendon neoformation.
The Journal of clinical investigation Feb, 2008 | Pubmed ID: 18246194
Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposure.
Bone May, 2008 | Pubmed ID: 18302991
Bioluminescent imaging in bone.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18463824
Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells.
Tissue engineering. Part A Oct, 2008 | Pubmed ID: 18620480
Maxillofacial-derived stem cells regenerate critical mandibular bone defect.
Tissue engineering. Part A Nov, 2008 | Pubmed ID: 18636943
Micro-electroporation of mesenchymal stem cells with alternating electrical current pulses.
Biomedical microdevices Feb, 2009 | Pubmed ID: 18815886
Genetically engineered mesenchymal stem cells: applications in spine therapy.
Regenerative medicine Jan, 2009 | Pubmed ID: 19105619
Expression of Brachyury in mesenchymal progenitor cells leads to cartilage-like tissue that is resistant to the destructive effect of rheumatoid arthritis synovial fibroblasts.
Journal of tissue engineering and regenerative medicine Feb, 2009 | Pubmed ID: 19156687
Functional fibered confocal microscopy: a promising tool for assessing tendon regeneration.
Tissue engineering. Part C, Methods Sep, 2009 | Pubmed ID: 19366317
Stem cell research: regenerating the skeleton and craniofacial complex.
The Alpha omegan Mar, 2009 | Pubmed ID: 19445429
Revealing the interplay of bone and cartilage in osteoarthritis through multimodal imaging of murine joints.
Bone Sep, 2009 | Pubmed ID: 19481620
The use of a synthetic oxygen carrier-enriched hydrogel to enhance mesenchymal stem cell-based bone formation in vivo.
Biomaterials Sep, 2009 | Pubmed ID: 19540585
Genetically modified cells in regenerative medicine and tissue engineering.
Advanced drug delivery reviews Jun, 2010 | Pubmed ID: 20114067
Direct gene therapy for bone regeneration: gene delivery, animal models, and outcome measures.
Tissue engineering. Part B, Reviews Feb, 2010 | Pubmed ID: 20143927
Monitoring of the effect of intervertebral disc nucleus pulposus ablation by MRI.
NMR in biomedicine Jul, 2010 | Pubmed ID: 20175140
Quantitative microstructural studies of the armor of the marine threespine stickleback (Gasterosteus aculeatus).
Journal of structural biology Sep, 2010 | Pubmed ID: 20433929
Peptide-modified "smart" hydrogels and genetically engineered stem cells for skeletal tissue engineering.
Biomacromolecules Jun, 2010 | Pubmed ID: 20462241
Quantitative, structural, and image-based mechanical analysis of nonunion fracture repaired by genetically engineered mesenchymal stem cells.
Journal of biomechanics Aug, 2010 | Pubmed ID: 20471652
Genetically modified mesenchymal stem cells induce mechanically stable posterior spine fusion.
Tissue engineering. Part A Dec, 2010 | Pubmed ID: 20618082
The effect of ex vivo dynamic loading on the osteogenic differentiation of genetically engineered mesenchymal stem cell model.
Journal of tissue engineering and regenerative medicine May, 2011 | Pubmed ID: 20740691
The effect of simulated microgravity on human mesenchymal stem cells cultured in an osteogenic differentiation system: a bioinformatics study.
Tissue engineering. Part A Nov, 2010 | Pubmed ID: 20807102
Targeted gene-and-host progenitor cell therapy for nonunion bone fracture repair.
Molecular therapy : the journal of the American Society of Gene Therapy Jan, 2011 | Pubmed ID: 20859259
Patterning osteogenesis by inducible gene expression in microfluidic culture systems.
Integrative biology : quantitative biosciences from nano to macro Jan, 2011 | Pubmed ID: 20924519
Microcomputed tomography-based structural analysis of various bone tissue regeneration models.
Nature protocols Jan, 2011 | Pubmed ID: 21212786
Gene-modified adult stem cells regenerate vertebral bone defect in a rat model.
Molecular pharmaceutics Oct, 2011 | Pubmed ID: 21834548
Three-dimensional structure of the shell plate assembly of the chiton Tonicella marmorea and its biomechanical consequences.
Journal of structural biology Feb, 2012 | Pubmed ID: 22248452
Gene therapy approaches to regenerating bone.
Advanced drug delivery reviews Sep, 2012 | Pubmed ID: 22429662
Smad8/BMP2-engineered mesenchymal stem cells induce accelerated recovery of the biomechanical properties of the Achilles tendon.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society Dec, 2012 | Pubmed ID: 22696396
Adeno-associated virus-coated allografts: a novel approach for cranioplasty.
Journal of tissue engineering and regenerative medicine Nov, 2012 | Pubmed ID: 22941779
Oxygenated environment enhances both stem cell survival and osteogenic differentiation.
Tissue engineering. Part A Mar, 2013 | Pubmed ID: 23215901
Nucleus pulposus degeneration alters properties of resident progenitor cells.
The spine journal : official journal of the North American Spine Society Jul, 2013 | Pubmed ID: 23578990
Transient overexpression of Pparγ2 and C/ebpα in mesenchymal stem cells induces brown adipose tissue formation.
Regenerative medicine May, 2013 | Pubmed ID: 23627824
Reliable chemical exchange saturation transfer imaging of human lumbar intervertebral discs using reduced-field-of-view turbo spin echo at 3.0 T.
NMR in biomedicine Dec, 2013 | Pubmed ID: 23893565
Real-time bioluminescence functional imaging for monitoring tissue formation and regeneration.
Methods in molecular biology (Clifton, N.J.) , 2013 | Pubmed ID: 23929106
PTH promotes allograft integration in a calvarial bone defect.
Molecular pharmaceutics Dec, 2013 | Pubmed ID: 24131143
Stem cell therapy for osteoporosis.
Current osteoporosis reports Mar, 2014 | Pubmed ID: 24407712
Detection of low back pain using pH level-dependent imaging of the intervertebral disc using the ratio of R1ρ dispersion and -OH chemical exchange saturation transfer (RROC).
Magnetic resonance in medicine Mar, 2015 | Pubmed ID: 24700573
Matrix stiffness determines the fate of nucleus pulposus-derived stem cells.
Biomaterials May, 2015 | Pubmed ID: 25725556
Isolation and characterization of mesenchymal stromal progenitors from the temporomandibular joint disc.
Journal of tissue engineering and regenerative medicine Jul, 2015 | Pubmed ID: 26193866
PTH induces systemically administered mesenchymal stem cells to migrate to and regenerate spine injuries.
Molecular therapy : the journal of the American Society of Gene Therapy Nov, 2015 | Pubmed ID: 26585691
Multiparameter evaluation of in vivo gene delivery using ultrasound-guided, microbubble-enhanced sonoporation.
Journal of controlled release : official journal of the Controlled Release Society Dec, 2015 | Pubmed ID: 26682505
BMP6-Engineered MSCs Induce Vertebral Bone Repair in a Pig Model: A Pilot Study.
Stem cells international , 2016 | Pubmed ID: 26770211
Controlling Arteriogenesis and Mast Cells Are Central to Bioengineering Solutions for Critical Bone Defect Repair Using Allografts.
Bioengineering (Basel, Switzerland) Mar, 2016 | Pubmed ID: 27141513
Human Induced Pluripotent Stem Cells Differentiate Into Functional Mesenchymal Stem Cells and Repair Bone Defects.
Stem cells translational medicine Nov, 2016 | Pubmed ID: 27400789
Quantitative chemical exchange saturation transfer MRI of intervertebral disc in a porcine model.
Magnetic resonance in medicine Dec, 2016 | Pubmed ID: 27670140
Teriparatide attenuates scarring around murine cranial bone allograft via modulation of angiogenesis.
Bone Apr, 2017 | Pubmed ID: 28119180
Systemic administration of mesenchymal stem cells combined with parathyroid hormone therapy synergistically regenerates multiple rib fractures.
Stem cell research & therapy Mar, 2017 | Pubmed ID: 28279202
In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs.
Science translational medicine May, 2017 | Pubmed ID: 28515335
Galina Shapiro1,
Maxim Bez1,
Wafa Tawackoli2,3,4,
Zulma Gazit1,2,3,5,
Dan Gazit1,2,3,4,5,
Gadi Pelled1,2,3,4
1Skeletal Biotech Laboratory, Hebrew University-Hadassah Faculty of Dental Medicine,
2Department of Surgery, Cedars-Sinai Medical Center,
3Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center,
4Biomedical Imaging Research Institute, Cedars-Sinai Medical Center,
5Department of Orthopedics, Cedars-Sinai Medical Center