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Division of Gastroenterology and Hepatology,
Department of Medicine,
Division of Gastroenterology and Hepatology, Department of Medicine
Klaus B. Piontek has not added Biography.
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A functional floxed allele of Pkd1 that can be conditionally inactivated in vivo.
Journal of the American Society of Nephrology : JASN Dec, 2004 | Pubmed ID: 15579506
Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.
Human molecular genetics Jan, 2006 | Pubmed ID: 16301212
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2006 | Pubmed ID: 16567633
Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.
Human molecular genetics Aug, 2007 | Pubmed ID: 17575307
Inactivation of Pkd1 in principal cells causes a more severe cystic kidney disease than in intercalated cells.
Kidney international Mar, 2009 | Pubmed ID: 19145237
Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.
Molecular and cellular biology May, 2009 | Pubmed ID: 19255143
Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.
Journal of the American Society of Nephrology : JASN Mar, 2010 | Pubmed ID: 20075061
Pkd1 and Pkd2 are required for normal placental development.
PloS one , 2010 | Pubmed ID: 20862291
Ectopic expression of Cux1 is associated with reduced p27 expression and increased apoptosis during late stage cyst progression upon inactivation of Pkd1 in collecting ducts.
Developmental dynamics : an official publication of the American Association of Anatomists Jun, 2011 | Pubmed ID: 21465620
Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1.
Human molecular genetics Dec, 2012 | Pubmed ID: 23001567
Network analysis of a Pkd1-mouse model of autosomal dominant polycystic kidney disease identifies HNF4α as a disease modifier.
PLoS genetics , 2012 | Pubmed ID: 23209428
Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures.
Biochemical and biophysical research communications Feb, 2014 | Pubmed ID: 24472557
Small-molecule screening of PC3 prostate cancer cells identifies tilorone dihydrochloride to selectively inhibit cell growth based on cyclin-dependent kinase 5 expression.
Oncology reports Jul, 2014 | Pubmed ID: 24841903
MicroRNA-224 Induces G1/S Checkpoint Release in Liver Cancer.
Journal of clinical medicine , 2015 | Pubmed ID: 26343737
Johns Hopkins University School of Medicine
Ling Li1,
Klaus B. Piontek1,
Vivek Kumbhari1,
Masaharu Ishida2,
Florin M. Selaru1
1Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine,
2Department of Surgery, Tohoku University
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