Akira Ono

Overexpression of the N-terminal domain of TSG101 inhibits HIV-1 budding by blocking late domain function.

Identification of the metal ion binding site on an RNA motif from hammerhead ribozymes using (15)N NMR spectroscopy.

Defects in human immunodeficiency virus budding and endosomal sorting induced by TSG101 overexpression.

Usefulness of a second temporary vena cava filter for preventing acute pulmonary thromboembolism.

Duplex and triplex formation of oligodeoxyribonucleotides containing nucleobase-intercalater conjugates.

Kinetic analysis of nucleotides incorporated opposite oxidized thymine bases on template DNA.

The NMR studies of substituent effects on the N-H...N hydrogen bond in duplex DNA using 2'-deoxynebularine and 15N labeled 5-substituted-2'-deoxyuridine base pairs.

Helix formation of oligodeoxyribonucleotides containing base-aromatic ring conjugates.

Highly selective binding of metal ions to thymine-thymine and cytosine-cytosine base pairs in DNA duplexes.

Cell-type-dependent targeting of human immunodeficiency virus type 1 assembly to the plasma membrane and the multivesicular body.

Development of an apparatus to control load by electromagnet for a motility system in vitro.

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

Highly selective oligonucleotide-based sensor for mercury(II) in aqueous solutions.

Phosphatidylinositol (4,5) bisphosphate regulates HIV-1 Gag targeting to the plasma membrane.

Pravastatin does not have a consistent antiviral effect in chronically HIV-infected individuals on antiretroviral therapy.

Current practice of preoperative fasting: a nationwide survey in Japanese anesthesia-teaching hospitals.

[The SAIL method: a new NMR approach for larger protection].

Role of lipid rafts in virus replication.

NMR assignment methods for the aromatic ring resonances of phenylalanine and tyrosine residues in proteins.

[Current status of pulmonary aspiration associated with general anesthesia: a nationwide survey in Japan].

Novel strategy for single nucleotide polymorphism (SNP) genotyping by heteroduplex analysis: specific stabilization of TT mismatch base pair by mercury (II) cation and CC mismatch base pair by silver (I) cation.

Association of human immunodeficiency virus type 1 gag with membrane does not require highly basic sequences in the nucleocapsid: use of a novel Gag multimerization assay.

MercuryII-mediated formation of thymine-HgII-thymine base pairs in DNA duplexes.

Genomic and functional analysis of the IncP-9 naphthalene-catabolic plasmid NAH7 and its transposon Tn4655 suggests catabolic gene spread by a tyrosine recombinase.

Sliding movements of molluscan and algal myosin attached to a magnetizable bead under a load controlled by electromagnet.

Recognition of oxidized thymine base on the single-stranded DNA by replication protein A.

NMR spectroscopic study of a DNA duplex with mercury-mediated T-T base pairs.

Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag.

Isolation and characterization of naphthalene-catabolic genes and plasmids from oil-contaminated soil by using two cultivation-independent approaches.

Development of novel oligonucleotide-based sensors which are highly Hg(II) selective and are insensitive to other heavy metal ions.

Formation of novel double-stranded structures formed by oligodeoxyribonucleotides carrying aromatic groups.

Metal ion binding of substituted pyrimidine base pairs in DNA duplexes.

Silver (I) cation specifically stabilizes heteroduplex with C:C mismatch base pair: toward the efficient detection of single nucleotide polymorphism (2).

Spectroscopic analysis of DNA duplexes including T-T mismatches.

Structural significances of pseudouridination and methylation of uridine residues in tRNA: X-ray analyses of DNA dodecamers containing uridine and pseudouridine.

Thermodynamic analyses of the specific interaction between T:T mismatch base pair and mercury (II) cation: toward the efficient detection of single nucleotide polymorphism (1).

NMR spectroscopic analyses of functional nucleic acids-metal interaction and their solution structure analyses.

Synthesis of metal ion-mediated double helical structures of modified oligonucleotides.

Synthesis and properties of the aromatic clusters arrayed along DNA strands.

Preparation of modified oligonucleotides by the post-synthetic modification on resin method.

Spectroscopic analyses of DNA duplexes in the presence of mercury ions.

Computational evaluation of the specific interaction between cation and mismatch base pair.

Thermodynamic analyses of the specific interaction between C:C mismatch base pair and silver (I) cation: toward the efficient detection of single nucleotide polymorphism.

Preparation of diverse metal binding sites along the helical structure of duplex DNA.

Structural analyses on the mercuryII-mediated T-T base pair.

Detection of C:C mismatch base pair by fluorescence spectral change upon addition of silver (I) cation: toward the efficient analyses of single nucleotide polymorphism.

Spectroscopic analysis of AgI-DNA complex.

Detection of T:T mismatch base pair by fluorescence spectral change upon addition of mercury (II) cation: toward the efficient analyses of single nucleotide polymorphism.

Thermodynamic analyses of the specific interaction between two C:C mismatch base pairs and silver (I) cations.

15N-15N J-coupling across Hg(II): direct observation of Hg(II)-mediated T-T base pairs in a DNA duplex.

[Lung cancer].

Evaluation of the recommended dose and efficacy of amrubicin as second- and third-line chemotherapy for small cell lung cancer.

Structural and physicochemical features on the metal-mediated base pairs.

Synthesis and properties of DNA duplexes containing cytosine analogs carrying phosphodiester functions.

Preparation and metal ion-binding of 4-N-substituted cytosine pairs in DNA duplexes.

Preparation of DNA double helical structures containing both mercury and silver ions.

Synthesis of DNA duplexes containing complexes of 5-modified pyrimidine bases and metal ions.

The specific interaction between two C:C mismatch base pairs and silver (I) cation.

The specific interaction between two T:T mismatch base pairs and mercury (II) cation.

Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.

[Subcellular locations at which HIV-1 assembles].

Mismatch base pair detection by fluorescence spectral change upon addition of metal cation--toward efficient analysis of single nucleotide polymorphism.

Interaction between the human immunodeficiency virus type 1 Gag matrix domain and phosphatidylinositol-(4,5)-bisphosphate is essential for efficient gag membrane binding.

Dominant negative inhibition of human immunodeficiency virus particle production by the nonmyristoylated form of gag.

Real-time visualization of HIV-1 GAG trafficking in infected macrophages.

Insertion sequence-based cassette PCR: cultivation-independent isolation of gamma-hexachlorocyclohexane-degrading genes from soil DNA.

Chemical composition of Coscinodiscus wailesii and the implication for nutrient ratios in a coastal water, Seto Inland Sea, Japan.

Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence.

S-1 treatment for chemorefractory thymic carcinoma.

The specific interaction between metal cation and mismatch base pair in duplex RNA.

Synthesis and properties of covalently linked antiparallel and parallel DNA duplexes.

[Advances in chemotherapy for lung cancer].

Nitrogen-15 NMR spectroscopy of N-metallated nucleic acids: insights into 15N NMR parameters and N-metal bonds.

Specific interactions between silver(I) ions and cytosine-cytosine pairs in DNA duplexes.

Methods for the study of HIV-1 assembly.

Structure of the putative 32 kDa myrosinase-binding protein from Arabidopsis (At3g16450.1) determined by SAIL-NMR.

Evaluation of the safety and compliance of 3-week cycles of vinorelbine on days 1 and 8 and cisplatin on day 1 as adjuvant chemotherapy in Japanese patients with completely resected pathological stage IB to IIIA non-small cell lung cancer: a retrospective study.

Metal-ion selectivity of chemically modified uracil pairs in DNA duplexes.

Efficacy of amrubicin for non-small cell lung cancer after failure of two or more prior chemotherapy regimens.

Activity of S-1 in advanced or recurrent gastric cancer patients after failure of prior chemotherapy, including irinotecan + cisplatin or fluorouracil (except S-1).

Quantitative fluorescence resonance energy transfer microscopy analysis of the human immunodeficiency virus type 1 Gag-Gag interaction: relative contributions of the CA and NC domains and membrane binding.

Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma.

Pooled analysis of the reports of erlotinib after failure of gefitinib for non-small cell lung cancer.

Gefitinib plus paclitaxel after failure of gefitinib in non-small cell lung cancer initially responding to gefitinib.

Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determination.

Metal ion binding of modified pyrimidine-base pairs in DNA duplexes.

Development of a novel device to trap heavy metal cations: application of the specific interaction between heavy metal cation and mismatch DNA base pair.

Synthesis and thermal denaturation studies of covalently linked DNA triplexes.

Development of a novel method to determine the concentration of heavy metal cations: application of the specific interaction between heavy metal cation and mismatch DNA base pair.

Actual status of adjuvant chemotherapy for non-small-cell lung cancer at one Japanese cancer center: the need for increased cooperation between medical oncologists and surgeons.

HIV-1 Assembly at the Plasma Membrane: Gag Trafficking and Localization.

Hydrogen exchange rate of tyrosine hydroxyl groups in proteins as studied by the deuterium isotope effect on C(zeta) chemical shifts.

Comparison of chemotherapy regimens for concurrent chemoradiotherapy in unresectable stage III non-small cell lung cancer.

Opposing mechanisms involving RNA and lipids regulate HIV-1 Gag membrane binding through the highly basic region of the matrix domain.

Evaluation of S-1 as third- or further-line chemotherapy in advanced non-small-cell lung cancer.

Relationships between plasma membrane microdomains and HIV-1 assembly.

HIV-1 assembly at the plasma membrane.

Optimized method for computing (18)O/(16)O ratios of differentially stable-isotope labeled peptides in the context of postdigestion (18)O exchange/labeling.

Evaluation of the efficacy and safety of chemotherapy for patients with wet stage IIIB/IV non-small-cell lung cancer aged 80 years old or more.

Hg(II) ion specifically binds with T:T mismatched base pair in duplex DNA.

Nucleocapsid promotes localization of HIV-1 gag to uropods that participate in virological synapses between T cells.

[Progress in structural studies of larger proteins by the SAIL-NMR method].

Synthesis of covalently linked parallel and antiparallel DNA duplexes containing the metal-mediated base pairs T-Hg(II)-T and C-Ag(I)-C.

18F-FDG uptake on PET helps predict outcome and response after treatment in unresectable thymic epithelial tumors.

Assembly and replication of HIV-1 in T cells with low levels of phosphatidylinositol-(4,5)-bisphosphate.

Efficacy of gefitinib for non-adenocarcinoma non-small-cell lung cancer patients harboring epidermal growth factor receptor mutations: a pooled analysis of published reports.

Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag.

Thermodynamic properties of the specific binding between Ag+ ions and C:C mismatched base pairs in duplex DNA.

Continuous EGFR-TKI administration following radiotherapy for non-small cell lung cancer patients with isolated CNS failure.

The risk of cytotoxic chemotherapy-related exacerbation of interstitial lung disease with lung cancer.

Molecular determinants that regulate plasma membrane association of HIV-1 Gag.

Gag induces the coalescence of clustered lipid rafts and tetraspanin-enriched microdomains at HIV-1 assembly sites on the plasma membrane.

Binding of metal ions by pyrimidine base pairs in DNA duplexes.

Alternative SAIL-Trp for robust aromatic signal assignment and determination of the χ(2) conformation by intra-residue NOEs.

Hydrogen exchange study on the hydroxyl groups of serine and threonine residues in proteins and structure refinement using NOE restraints with polar side-chain groups.

Viruses and lipids.

Continuous administration of EGFR-TKIs following radiotherapy after disease progression in bone lesions for non-small cell lung cancer.

Phase I and pharmacokinetic study of dacomitinib (PF-00299804), an oral irreversible, small molecule inhibitor of human epidermal growth factor receptor-1, -2, and -4 tyrosine kinases, in Japanese patients with advanced solid tumors.

Prognostic impact of circulating tumor cells in patients with small cell lung cancer.

Comparison of vinorelbine plus cisplatin and S-1 plus cisplatin in concurrent chemoradiotherapeutic regimens for unresectable stage III non-small cell lung cancer.

Correlations between serial pro-gastrin-releasing peptide and neuron-specific enolase levels, and the radiological response to treatment and survival of patients with small-cell lung cancer.

The role of βIII-tubulin in non-small cell lung cancer patients treated by taxane-based chemotherapy.

Raman spectroscopic detection of the T-Hg II-T base pair and the ionic characteristics of mercury.

Metal ion-binding properties of DNA duplexes containing thiopyrimidine base pairs.

Prognostic factors and clinical outcome of patients with lung adenocarcinoma with carcinomatous meningitis.

Ag(I) ion mediated formation of a C-A mispair by DNA polymerases.

[Multidisciplinary treatment of leptomeningeal metastasis in patients with lung adenocarcinoma: the triple modality combination of EGFR-TKI, VP shunt and irradiation].

Post-digestion ¹⁸O exchange/labeling for quantitative shotgun proteomics of membrane proteins.

Thermodynamic and structural properties of the specific binding between Ag⁺ ion and C:C mismatched base pair in duplex DNA to form C-Ag-C metal-mediated base pair.

Dynamic Association between HIV-1 Gag and Membrane Domains.

Differential efficacy of docetaxel according to non-small cell lung cancer histology and the therapeutic effect of epidermal growth factor receptor tyrosine kinase inhibitors.

Human endogenous retrovirus K Gag coassembles with HIV-1 Gag and reduces the release efficiency and infectivity of HIV-1.

Feasibility of postoperative adjuvant chemotherapy of cisplatin plus vinorelbine for completely resected non-small-cell lung cancer: a retrospective study in Japan.

The impact of clinical outcomes according to EGFR mutation status in patients with locally advanced lung adenocarcinoma who recieved concurrent chemoradiotherapy.

Chemoradiotherapy for limited-disease small-cell lung cancer in elderly patients aged 75 years or older.

Comparison of chemotherapeutic efficacy between LCNEC diagnosed using large specimens and possible LCNEC diagnosed using small biopsy specimens.

Efficacy of rechallenge chemotherapy in patients with sensitive relapsed small cell lung cancer.

Roles played by capsid-dependent induction of membrane curvature and Gag-ESCRT interactions in tetherin recruitment to HIV-1 assembly sites.

Efficacy of bevacizumab-containing chemotherapy for non-squamous non-small cell lung cancer with bone metastases.

HIV-1 Gag associates with specific uropod-directed microdomains in a manner dependent on its MA highly basic region.

Evidence in support of RNA-mediated inhibition of phosphatidylserine-dependent HIV-1 Gag membrane binding in cells.

Bacterial curli protein promotes the conversion of PAP248-286 into the amyloid SEVI: cross-seeding of dissimilar amyloid sequences.

Formation of a thymine-Hg(II)-thymine metal-mediated DNA base pair: proposal and theoretical calculation of the reaction pathway.

Size-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system.

Acute lung injury with alveolar hemorrhage as adverse drug reaction related to crizotinib.

Prognostic impact of serum CYFRA 21-1 in patients with advanced lung adenocarcinoma: a retrospective study.

Comparison of the time-to-response between radiotherapy and epidermal growth factor receptor--tyrosine kinase inhibitors for advanced non-small cell lung cancer with EGFR mutation.

Differential isotope-labeling for Leu and Val residues in a protein by E. coli cellular expression using stereo-specifically methyl labeled amino acids.

¹⁸F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms.

The structure of metallo-DNA with consecutive thymine-HgII-thymine base pairs explains positive entropy for the metallo base pair formation.

Progression-free survival at 2 years is a reliable surrogate marker for the 5-year survival rate in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy.

Crystal structure of metallo DNA duplex containing consecutive Watson-Crick-like T-Hg(II)-T base pairs.

Efficacy and safety of platinum combination chemotherapy re-challenge for relapsed patients with non-small-cell lung cancer after postoperative adjuvant chemotherapy of cisplatin plus vinorelbine.

iSVP: an integrated structural variant calling pipeline from high-throughput sequencing data.

Comparison of cisplatin plus pemetrexed and cisplatin plus gemcitabine for the treatment of malignant pleural mesothelioma in Japanese patients.

Prognostic impact of 18F-FDG uptake on PET in non-small cell lung cancer patients with postoperative recurrence following platinum-based chemotherapy.

Outcome of platinum-based chemotherapy for non-small-cell lung cancer patients with pleural dissemination detected during surgery.

Molecular profiling of small cell lung cancer in a Japanese cohort.

Phase II study of erlotinib for acquired resistance to gefitinib in patients with advanced non-small cell lung cancer.

Regulated incorporation of two different metal ions into programmed sites in a duplex by DNA polymerase catalyzed primer extension.

Toxicity and efficacy of chemotherapy for non-small cell lung cancer with cavitary lesions.

Perianal metastasis of non-small cell lung cancer.

Multiplexed molecular profiling of lung cancer using pleural effusion.

Individual-level data on the relationships of progression-free survival and post-progression survival with overall survival in patients with advanced non-squamous non-small cell lung cancer patients who received second-line chemotherapy.

Hg2+-trapping beads: Hg2+-specific recognition through thymine-Hg(II)-thymine base pairing.

Roles played by acidic lipids in HIV-1 Gag membrane binding.

Identification of actionable mutations in malignant pleural mesothelioma.

Phase I study of Efatutazone, an oral PPARγ agonist, in patients with metastatic solid tumors.

Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles.

The effect of gefitinib in patients with postoperative recurrent non-small cell lung cancer harboring mutations of the epidermal growth factor receptor.

Prospective genetic profiling of squamous cell lung cancer and adenosquamous carcinoma in Japanese patients by multitarget assays.

Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer.

Membrane binding and subcellular localization of retroviral Gag proteins are differentially regulated by MA interactions with phosphatidylinositol-(4,5)-bisphosphate and RNA.

Effect of platinum-based chemotherapy for non-small cell lung cancer patients with interstitial lung disease.

Isolation of oxygenase genes for indigo-forming activity from an artificially polluted soil metagenome by functional screening using Pseudomonas putida strains as hosts.

Progression-free survival, post-progression survival, and tumor response as surrogate markers for overall survival in patients with extensive small cell lung cancer.

Primary malignant melanoma of the trachea: A case report.

Characterizing natural hydrogel for reconstruction of three-dimensional lymphoid stromal network to model T-cell interactions.

Disease flare after gefitinib discontinuation.

The efficacy of amrubicin on central nervous system metastases originating from small-cell lung cancer: a case series of eight patients.

Development of a photolabile protecting group for phosphodiesters in oligonucleotides.

Direct detection of the mercury-nitrogen bond in the thymine-Hg(II)-thymine base-pair with (199)Hg NMR spectroscopy.

Comparison of platinum combination re-challenge therapy and docetaxel monotherapy in non-small cell lung cancer patients previously treated with platinum-based chemoradiotherapy.

Phosphatidylinositol-(4,5)-Bisphosphate Acyl Chains Differentiate Membrane Binding of HIV-1 Gag from That of the Phospholipase Cδ1 Pleckstrin Homology Domain.

ProGRP is a possible tumor marker for patients with Ewing sarcoma.

[Membrane Binding of Retroviral Gag Proteins].

High-Resolution Crystal Structure of a Silver(I)-RNA Hybrid Duplex Containing Watson-Crick-like C-Silver(I)-C Metallo-Base Pairs.

Structures, physicochemical properties, and applications of T-Hg(II)-T, C-Ag(I)-C, and other metallo-base-pairs.

Exploring a DNA Sequence for the Three-Dimensional Structure Determination of a Silver(I)-Mediated C-C Base Pair in a DNA Duplex By (1)H NMR Spectroscopy.

Bioreductive deprotection of 4-nitrobenzyl group on thymine base in oligonucleotides for the activation of duplex formation.

Glutathione-triggered activation of the model of pro-oligonucleotide with benzyl protecting groups at the internucleotide linkage.

Prognostic significance of diabetes mellitus in locally advanced non-small cell lung cancer.

Methods to Study Determinants for Membrane Targeting of HIV-1 Gag In Vitro.

Differences in the efficacy of S-1 monotherapy according to histological type in pretreated patients with advanced non-small cell lung cancer.

Clinical impact of post-progression survival on overall survival in patients with limited-stage disease small cell lung cancer after first-line chemoradiotherapy.

Dose escalation study of proton beam therapy with concurrent chemotherapy for stage III non-small cell lung cancer.

Rebiopsy for patients with non-small-cell lung cancer after epidermal growth factor receptor-tyrosine kinase inhibitor failure.

Comparison of the efficacy of radiotherapy between postoperative mediastinal lymph node recurrence and stage III disease in non-small cell lung cancer patients.

The molecular determinants directing HIV-1 Gag assembly to the virus-containing compartments in primary macrophages.