Thomas Hankemeier

Microbial metabolomics: replacing trial-and-error by the unbiased selection and ranking of targets.

Sign constraints improve the detection of differences between complex spectral data sets: LC-IR as an example.

Typical diffusion behaviour in packaging polymers - application to functional barriers.

Microbial metabolomics with gas chromatography/mass spectrometry.

Effects of growth conditions and processing on Rehmannia glutinosa using fingerprint strategy.

Hyphenation of infrared spectroscopy to liquid chromatography for qualitative and quantitative polymer analysis: degradation of poly(bisphenol A)carbonate.

Simultaneous quantitative analysis of metabolites using ion-pair liquid chromatography-electrospray ionization mass spectrometry.

Metabolite profiling of human urine by CE-ESI-MS using separation electrolytes at low pH.

Metabolomics-based systems biology and personalized medicine: moving towards n = 1 clinical trials?

CE-ESI-MS of biological anions in plastic capillaries at high pH.

Microbial metabolomics: toward a platform with full metabolome coverage.

Profiling of endogenous peptides in human synovial fluid by NanoLC-MS: method validation and peptide identification.

Recent methodology in the phytochemical analysis of ginseng.

Higher mass loadability in comprehensive two-dimensional gas chromatography-mass spectrometry for improved analytical performance in metabolomics analysis.

Similarities and differences in lipidomics profiles among healthy monozygotic twin pairs.

Comprehensive analysis of the metabolome of Pseudomonas putida S12 grown on different carbon sources.

Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: investigating differential effects among statins.

Solution titration by wall deprotonation during capillary filling of silicon oxide nanochannels.

RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model.

Bioconversion of red ginseng saponins in the gastro-intestinal tract in vitro model studied by high-performance liquid chromatography-high resolution Fourier transform ion cyclotron resonance mass spectrometry.

Alkaloid profiling of the Chinese herbal medicine Fuzi by combination of matrix-assisted laser desorption ionization mass spectrometry with liquid chromatography-mass spectrometry.

Analytical strategies in lipidomics and applications in disease biomarker discovery.

Feasibility of electrodialysis as a fast and selective sample preparation method for the profiling of low-abundant peptides in biofluids.

The effect of preanalytical factors on stability of the proteome and selected metabolites in cerebrospinal fluid (CSF).

Metabolic profiling of ultrasmall sample volumes with GC/MS: from microliter to nanoliter samples.

Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research.

Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics.

Equating, or correction for between-block effects with application to body fluid LC-MS and NMR metabolomics data sets.

Comprehensive LC-MS E lipidomic analysis using a shotgun approach and its application to biomarker detection and identification in osteoarthritis patients.

Comparative transcriptional profiling and preliminary study on heterosis mechanism of super-hybrid rice.

Quantitative proteomics and metabolomics analysis of normal human cerebrospinal fluid samples.

In vivo D2O labeling to quantify static and dynamic changes in cholesterol and cholesterol esters by high resolution LC/MS.

Systems biology-based diagnostic principles as pillars of the bridge between Chinese and Western medicine.

Online capillary liquid-liquid electroextraction of peptides as fast pre-concentration prior to LC-MS.

LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery.

Semi-automated non-target processing in GC × GC-MS metabolomics analysis: applicability for biomedical studies.

Traditional processing strongly affects metabolite composition by hydrolysis in Rehmannia glutinosa roots.

Plasma and liver lipidomics response to an intervention of rimonabant in ApoE*3Leiden.CETP transgenic mice.

Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics.

Elemental composition determination based on MS(n).

Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5).

Anacetrapib promotes reverse cholesterol transport and bulk cholesterol excretion in Syrian golden hamsters.

Single-electrolyte isotachophoresis using a nanochannel-induced depletion zone.

Linking biological activity with herbal constituents by systems biology-based approaches: effects of Panax ginseng in type 2 diabetic Goto-Kakizaki rats.

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives.

Sub-typing of rheumatic diseases based on a systems diagnosis questionnaire.

Localization of fatty acyl and double bond positions in phosphatidylcholines using a dual stage CID fragmentation coupled with ion mobility mass spectrometry.

The impact of delayed storage on the measured proteome and metabolome of human cerebrospinal fluid.

Enrichment of viable bacteria in a micro-volume by free-flow electrophoresis.

[An ultra performance liquid chromatography-time-of-flight-mass spectrometric method for fast analysis of ginsenosides in Panax ginseng root].

An efficient hydrophilic interaction liquid chromatography separation of 7 phospholipid classes based on a diol column.

Understanding and classifying metabolite space and metabolite-likeness.

Lipidomics reveals multiple pathway effects of a multi-components preparation on lipid biochemistry in ApoE*3Leiden.CETP mice.

Metabolomics of cerebrospinal fluid reveals changes in the central nervous system metabolism in a rat model of multiple sclerosis.

Metabolite identification using automated comparison of high-resolution multistage mass spectral trees.

Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels.

Hierarchical clustering analysis of blood plasma lipidomics profiles from mono- and dizygotic twin families.

On-line large-volume electroextraction coupled to liquid chromatography-mass spectrometry to improve detection of peptides.

Quantitative profiling of oxylipins through comprehensive LC-MS/MS analysis: application in cardiac surgery.

Instrument and process independent binning and baseline correction methods for liquid chromatography-high resolution-mass spectrometry deconvolution.

MetiTree: a web application to organize and process high-resolution multi-stage mass spectrometry metabolomics data.

Fragmentation trees for the structural characterisation of metabolites.

Characterization of rheumatoid arthritis subtypes using symptom profiles, clinical chemistry and metabolomics measurements.

OMG: Open Molecule Generator.

Feasibility of electroextraction as versatile sample preconcentration for fast and sensitive analysis of urine metabolites, demonstrated on acylcarnitines.

Tunable ionic mobility filter for depletion zone isotachophoresis.

Increase in short-chain ceramides correlates with an altered lipid organization and decreased barrier function in atopic eczema patients.

Assessing the metabolic effects of prednisolone in healthy volunteers using urine metabolic profiling.

How do metabolites differ from their parent molecules and how are they excreted?

Automated pipeline for de novo metabolite identification using mass-spectrometry-based metabolomics.

Lipidomics of familial longevity.

Pre-processing liquid chromatography/high-resolution mass spectrometry data: extracting pure mass spectra by deconvolution from the invariance of isotopic distribution.

Solvent Exchange Module for LC-NMR Hyphenation Using Machine Vision-Controlled Droplet Evaporation.

Three-phase electroextraction: a new (online) sample purification and enrichment method for bioanalysis.

A branched biosynthetic pathway is involved in production of roquefortine and related compounds in Penicillium chrysogenum.

Human metabolomics: strategies to understand biology.

Microfluidic titer plate for stratified 3D cell culture.

Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI).

Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes.

Postprandial fatty acid specific changes in circulating oxylipins in lean and obese men after high-fat challenge tests.

A new approach to untargeted integration of high resolution liquid chromatography-mass spectrometry data.

Elastomeric microvalves as tunable nanochannels for concentration polarization.

Novel key metabolites reveal further branching of the roquefortine/meleagrin biosynthetic pathway.

The potential of electrophoretic sample pretreatment techniques and new instrumentation for bioanalysis, with a focus on peptidomics and metabolomics.

Capillary electrophoresis-mass spectrometry using a flow-through microvial interface for cationic metabolome analysis.

Novel hollow microneedle technology for depth-controlled microinjection-mediated dermal vaccination: a study with polio vaccine in rats.

Isotachophoretic phenomena in electric field gradient focusing: perspectives for sample preparation and bioassays.

A protective lipidomic biosignature associated with a balanced omega-6/omega-3 ratio in fat-1 transgenic mice.

Phaseguide assisted liquid lamination for magnetic particle-based assays.

Simple capillary electrophoresis-mass spectrometry method for complex glycan analysis using a flow-through microvial interface.

Metabolomics profiling for identification of novel potential markers in early prediction of preeclampsia.

A non-canonical NRPS is involved in the synthesis of fungisporin and related hydrophobic cyclic tetrapeptides in Penicillium chrysogenum.

Enhanced lipid isomer separation in human plasma using reversed-phase UPLC with ion-mobility/high-resolution MS detection.

Continuous-flow microelectroextraction for enrichment of low abundant compounds.

Phaseguides as tunable passive microvalves for liquid routing in complex microfluidic networks.

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation.

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry.

Lab-on-a-Chip hyphenation with mass spectrometry: strategies for bioanalytical applications.

Gas pressure assisted microliquid-liquid extraction coupled online to direct infusion mass spectrometry: a new automated screening platform for bioanalysis.

Roux-en-Y gastric bypass surgery, but not calorie restriction, reduces plasma branched-chain amino acids in obese women independent of weight loss or the presence of type 2 diabetes.

Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen.

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues.

Individualization of treatments with drugs metabolized by CES1: combining genetics and metabolomics.

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture.

Matrix Effect Compensation in Small-Molecule Profiling for an LC-TOF Platform Using Multicomponent Postcolumn Infusion.

p53 attenuates AKT signaling by modulating membrane phospholipid composition.

Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons.

Microfluidic 3D cell culture: from tools to tissue models.

First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach.

Effects of metformin on metabolite profiles and LDL cholesterol in patients with type 2 diabetes.

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access.

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Sheathless capillary electrophoresis-mass spectrometry for anionic metabolic profiling.

Collagen Induced Arthritis in DBA/1J Mice Associates with Oxylipin Changes in Plasma.

Weight loss predictability by plasma metabolic signatures in adults with obesity and morbid obesity of the DiOGenes study.

Delayed luminescence: an experimental protocol for Chinese herbal medicines.

Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study.

Electroextraction and electromembrane extraction: Advances in hyphenation to analytical techniques.

Migraine biomarkers in cerebrospinal fluid: A systematic review and meta-analysis.

Discovery of biochemical biomarkers for aggression: A role for metabolomics in psychiatry.

A Chinese literature overview on ultra-weak photon emission as promising technology for studying system-based diagnostics.

Bacterial surface layer proteins as a novel capillary coating material for capillary electrophoretic separations.

Serum-Based Oxylipins Are Associated with Outcomes in Primary Prevention Implantable Cardioverter Defibrillator Patients.

Metabolic characterization of the natural progression of chronic hepatitis B.

Effects of growth altitude on chemical constituents and delayed luminescence properties in medicinal rhubarb.

Metabolomics profiling of the free and total oxidised lipids in urine by LC-MS/MS: application in patients with rheumatoid arthritis.

Next-generation capillary electrophoresis-mass spectrometry approaches in metabolomics.

Tracking biochemical changes correlated with ultra-weak photon emission using metabolomics.

Exploring the Inflammatory Metabolomic Profile to Predict Response to TNF-α Inhibitors in Rheumatoid Arthritis.

Pharmacokinetic Modeling of Paracetamol Uptake and Clearance in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates with Five Orders of Magnitude.

Metabolomics enables precision medicine: "A White Paper, Community Perspective".

Differences between serum polar lipid profiles of male and female rheumatoid arthritis patients in response to glucocorticoid treatment.

Classification for Longevity Potential: The Use of Novel Biomarkers.

Measuring ultra-weak photon emission as a non-invasive diagnostic tool for detecting early-stage type 2 diabetes: A step toward personalized medicine.

Quantitative profiling of endocannabinoids and related -acylethanolamines in human CSF using nano LC-MS/MS.

Integration of pharmacometabolomics with pharmacokinetics and pharmacodynamics: towards personalized drug therapy.

Feasibility of ultra-performance liquid chromatography-ion mobility-time-of-flight mass spectrometry in analyzing oxysterols.

Characterization of the therapeutic properties of Chinese herbal materials by measuring delayed luminescence and dendritic cell-based immunomodulatory response.

Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis.

Role of amino acids in rheumatoid arthritis studied by metabolomics.

Metabolic network failures in Alzheimer's disease: A biochemical road map.

Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism.

Integrating clinical metabolomics-based biomarker discovery and clinical pharmacology to enable precision medicine.

Towards personalized treatment of pain using a quantitative systems pharmacology approach.

Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474.

Fetal Metabolic Stress Disrupts Immune Homeostasis and Induces Proinflammatory Responses in Human Immunodeficiency Virus Type 1- and Combination Antiretroviral Therapy-Exposed Infants.

Endocannabinoid tone is higher in healthy lean South Asian than white Caucasian men.

Metabolomics based markers predict type 2 diabetes in a 14-year follow-up study.

Membrane-free culture and real-time barrier integrity assessment of perfused intestinal epithelium tubes.

A Mendelian Randomization Study of Metabolite Profiles, Fasting Glucose, and Type 2 Diabetes.

Cellular glutathione levels in HL-60 cells during respiratory burst are not correlated with ultra-weak photon emission.

Blood-based metabolic signatures in Alzheimer's disease.

The future of metabolomics in ELIXIR.

Therapy response testing of breast cancer in a 3D high-throughput perfused microfluidic platform.

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies.

Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes.

Pharmacological targeting of ROS reaction network in myeloid leukemia cells monitored by ultra-weak photon emission.

A metabolomics study of Qiliqiangxin in a rat model of heart failure: a reverse pharmacology approach.

Development and application of a UHPLC-MS/MS metabolomics based comprehensive systemic and tissue-specific screening method for inflammatory, oxidative and nitrosative stress.

Strategies to assess and optimize stability of endogenous amines during cerebrospinal fluid sampling.

Mass spectrometric recommendations for Quan/Qual analysis using liquid-chromatography coupled to quadrupole time-of-flight mass spectrometry.

Fusing metabolomics data sets with heterogeneous measurement errors.

High-Resolution Analysis of the Peptidoglycan Composition in Streptomyces coelicolor.

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight.

Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology.

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome.

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers.

Persistent metabolic changes in HIV-infected patients during the first year of combination antiretroviral therapy.

PhenoMeNal: processing and analysis of metabolomics data in the cloud.

Utility of sheathless capillary electrophoresis-mass spectrometry for metabolic profiling of limited sample amounts.

Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools.

Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.

Blood-Based Biomarkers of Quinpirole Pharmacology: Cluster-Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain.

High Fat Diet Increases Circulating Endocannabinoids Accompanied by Increased Synthesis Enzymes in Adipose Tissue.

Discovery of novel glycerolated quinazolinones from Streptomyces sp. MBT27.

Automated microfluidic cell culture of stem cell derived dopaminergic neurons.

Impact of post-hatching maturation on the pharmacokinetics of paracetamol in zebrafish larvae.

Global testing of shifts in metabolic phenotype.

The influence of neuronal electrical activity on the mammalian central clock metabolome.

Capillary Electrophoresis-Mass Spectrometry for Metabolic Profiling of Biomass-Limited Samples.

Interoperable and scalable data analysis with microservices: applications in metabolomics.

Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics.

CE-MS for anionic metabolic profiling: An overview of methodological developments.

Mechanistic and Quantitative Understanding of Pharmacokinetics in Zebrafish Larvae through Nanoscale Blood Sampling and Metabolite Modeling of Paracetamol.

LC-MS/MS analysis of the central energy and carbon metabolites in biological samples following derivatization by dimethylaminophenacyl bromide.

Intersubject and Intrasubject Variability of Potential Plasma and Urine Metabolite and Protein Biomarkers in Healthy Human Volunteers.

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum.

Interstitial Flow Recapitulates Gemcitabine Chemoresistance in A 3D Microfluidic Pancreatic Ductal Adenocarcinoma Model by Induction of Multidrug Resistance Proteins.

Supervised Multidimensional Item Response Theory Modeling of Pediatric Iatrogenic Withdrawal Symptoms.

Chemical Diversity and Classification of Secondary Metabolites in Nine Bryophyte Species.

Impaired serine metabolism complements LRRK2-G2019S pathogenicity in PD patients.

STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse.