Hassan Y. Naim

The prosequence of human lactase-phlorizin hydrolase modulates the folding of the mature enzyme.

Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains.

Sucrase is an intramolecular chaperone located at the C-terminal end of the sucrase-isomaltase enzyme complex.

Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein.

Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.

A glutamine to proline exchange at amino acid residue 1098 in sucrase causes a temperature-sensitive arrest of sucrase-isomaltase in the endoplasmic reticulum and cis-Golgi.

Distinct cytoskeletal tracks direct individual vesicle populations to the apical membrane of epithelial cells.

Annexin II is required for apical transport in polarized epithelial cells.

Congenital sucrase-isomaltase deficiency because of an accumulation of the mutant enzyme in the endoplasmic reticulum.

Antigen transport and cytoskeletal characteristics of a distinct enterocyte population in inflammatory bowel diseases.

A novel sorting signal for intracellular localization is present in the S protein of a porcine coronavirus but absent from severe acute respiratory syndrome-associated coronavirus.

Binding of Par-4 to the actin cytoskeleton is essential for Par-4/Dlk-mediated apoptosis.

Trafficking pathways of Cx49-GFP in living mammalian cells.

Alpha-kinase 1, a new component in apical protein transport.

A phenylalanine-based folding determinant in intestinal sucrase-isomaltase that functions in the context of a quality control mechanism beyond the endoplasmic reticulum.

Impaired trafficking of mutants of lysosomal glucocerebrosidase in Gaucher's disease.

Apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing.

A novel type of detergent-resistant membranes may contribute to an early protein sorting event in epithelial cells.

Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption.

A mutation in aminopeptidase N (CD13) isolated from a patient suffering from leukemia leads to an arrest in the endoplasmic reticulum.

Requirement for galectin-3 in apical protein sorting.

Ex vivo biochemical analysis of CFTR in human rectal biopsies.

Altered folding, turnover, and polarized sorting act in concert to define a novel pathomechanism of congenital sucrase-isomaltase deficiency.

Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus.

Transcoronary delivery of bone marrow cells to the infarcted murine myocardium: feasibility, cellular kinetics, and improvement in cardiac function.

Both cleavage products of the mCLCA3 protein are secreted soluble proteins.

Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4.

A genetically engineered prime-boost vaccination strategy for oculonasal delivery with poly(D,L-lactic-co-glycolic acid) microparticles against infection of turkeys with avian Metapneumovirus.

Different glycoforms of prostate-specific membrane antigen are intracellularly transported through their association with distinct detergent-resistant membranes.

Mosaic pattern of sucrase isomaltase deficiency in two brothers.

Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose.

Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2.

Association of a GPI-anchored protein with detergent-resistant membranes facilitates its trafficking through the early secretory pathway.

The influence of linoleic and linolenic acid on the activity and intracellular localisation of phospholipase D in COS-1 cells.

Compound heterozygous mutations affect protein folding and function in patients with congenital sucrase-isomaltase deficiency.

Impaired trafficking and subcellular localization of a mutant lactase associated with congenital lactase deficiency.

The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways.

Impact of glycosylation and detergent-resistant membranes on the function of intestinal sucrase-isomaltase.

Toxic peptides in Frazer's fraction interact with the actin cytoskeleton and affect the targeting and function of intestinal proteins.

Domains in biological membranes.

Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection.

Endocytotic segregation of gliadin peptide 31-49 in enterocytes.

Congenital and putatively acquired forms of sucrase-isomaltase deficiency in infancy: effects of sacrosidase therapy.

Structural hierarchy of regulatory elements in the folding and transport of an intestinal multidomain protein.

Protocadherin of the liver, kidney, and colon associates with detergent-resistant membranes during cellular differentiation.

Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.

A modified lipid composition in Fabry disease leads to an intracellular block of the detergent-resistant membrane-associated dipeptidyl peptidase IV.

TGFα-associated MUC2 and MUC3 expression of the gastric epithelium in Menetrier's disease during remission of ulcerative colitis.

The dual role of annexin II in targeting of brush border proteins and in intestinal cell polarity.

Demonstration of free fatty acids in the integument of semi-aquatic and aquatic mammals.

Impairment of protein trafficking by direct interaction of gliadin peptides with actin.

Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.

Unexpected high digestion rate of cooked starch by the Ct-maltase-glucoamylase small intestine mucosal α-glucosidase subunit.

Cadherin-related protein 24 induces morphological changes and partial cell polarization by facilitating direct cell-cell interactions.

A novel role for the transcription factor HIF-1α in the formation of mast cell extracellular traps.

β-Glucan protects neutrophil extracellular traps against degradation by Aeromonas hydrophila in carp (Cyprinus carpio).

Miglustat-induced intestinal carbohydrate malabsorption is due to the inhibition of α-glucosidases, but not β-galactosidases.

Starch source influences dietary glucose generation at the mucosal α-glucosidase level.

Research progress reported at the 50th Anniversary of the Discovery of Congenital Sucrase-Isomaltase Deficiency Workshop.

Congenital sucrase-isomaltase deficiency: heterogeneity of inheritance, trafficking, and function of an intestinal enzyme complex.

Investigations of the structures and inhibitory properties of intestinal maltase glucoamylase and sucrase isomaltase.

Congenital sucrase-isomaltase deficiency: summary of an evaluation in one family.

Transient sucrose and starch intolerance.

Retinal glycoprotein enrichment by concanavalin a enabled identification of novel membrane autoantigen synaptotagmin-1 in equine recurrent uveitis.

Cloning and characterization of canine prostate-specific membrane antigen.

Discriminatory Role of Detergent-Resistant Membranes in the Dimerization and Endocytosis of Prostate-Specific Membrane Antigen.

Isolation and analysis of membrane lipids and lipid rafts in common carp (Cyprinus carpio L.).

The effect of β-glucan on formation and functionality of neutrophil extracellular traps in carp (Cyprinus carpio L.).

Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C.

Enrofloxacin enhances the formation of neutrophil extracellular traps in bovine granulocytes.

Lidocaine effect on flotillin-2 distribution in detergent-resistant membranes of equine jejunal smooth muscle in vitro.

Long term differential consequences of miglustat therapy on intestinal disaccharidases.

Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases.

Canine epidermal lipid sampling by skin scrub revealed variations between different body sites and normal and atopic dogs.

Lipid alterations in human blood-derived neutrophils lead to formation of neutrophil extracellular traps.

The antimicrobial peptide LL-37 facilitates the formation of neutrophil extracellular traps.

Genetic reporter analysis reveals an expandable reservoir of OCT4+ cells in adult skin.

Precision-cut intestinal slices as a culture system to analyze the infection of differentiated intestinal epithelial cells by avian influenza viruses.

Identification of a novel DNase of Streptococcus suis (EndAsuis) important for neutrophil extracellular trap degradation during exponential growth.

Congenital lactose intolerance is triggered by severe mutations on both alleles of the lactase gene.

Central Nervous System Demyelination and Remyelination is Independent from Systemic Cholesterol Level in Theiler's Murine Encephalomyelitis.

Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle.

The Pathobiochemistry of Gastrointestinal Symptoms in a Patient with Niemann-Pick Type C Disease.

The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers.

In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus.

Yersinia enterocolitica-mediated degradation of neutrophil extracellular traps (NETs).

A Novel SLC27A4 Splice Acceptor Site Mutation in Great Danes with Ichthyosis.

Hypoxia Decreases Invasin-Mediated Yersinia enterocolitica Internalization into Caco-2 Cells.

What to do with high autofluorescence background in pancreatic tissues - an efficient Sudan black B quenching method for specific immunofluorescence labelling.

The multiple roles of sucrase-isomaltase in the intestinal physiology.

Endocytosis in enterocytes.

The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens.

Effects of SecDF on the antimicrobial functions of cathelicidins against Staphylococcus aureus.

Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils.

Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors.

Cross-talk between intestinal epithelial cells and immune cells in inflammatory bowel disease.

Molecular biology of the gut.

Guarea kunthiana Bark Extract Enhances the Antimicrobial Activities of Human and Bovine Neutrophils.

Alterations in membrane trafficking and pathophysiological implications in lysosomal storage disorders.

Prostate-specific membrane antigen (PSMA) assembles a macromolecular complex regulating growth and survival of prostate cancer cells "in vitro" and correlating with progression "in vivo".

Structural determinants for transport of lactase phlorizin-hydrolase in the early secretory pathway as a multi-domain membrane glycoprotein.

Measuring oxygen levels in Caco-2 cultures.

Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome.

Formation of Neutrophil Extracellular Traps under Low Oxygen Level.

Molecular pathogenicity of novel sucrase-isomaltase mutations found in congenital sucrase-isomaltase deficiency patients.

Antimicrobial activity of HL-60 cells compared to primary blood-derived neutrophils against Staphylococcus aureus.