Jian Q. Feng

Dissection of promoter control modules that direct Bmp4 expression in the epithelium-derived components of hair follicles.

Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo.

NF-kappaB specifically activates BMP-2 gene expression in growth plate chondrocytes in vivo and in a chondrocyte cell line in vitro.

Identification of the haematopoietic stem cell niche and control of the niche size.

Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.

Critical role of calbindin-D28k in calcium homeostasis revealed by mice lacking both vitamin D receptor and calbindin-D28k.

Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype.

Dentin matrix protein 1 gene cis-regulation: use in osteocytes to characterize local responses to mechanical loading in vitro and in vivo.

DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis.

periostin null mice exhibit dwarfism, incisor enamel defects, and an early-onset periodontal disease-like phenotype.

Differential regulation of dentin matrix protein 1 expression during odontogenesis.

Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development.

E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongation.

Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion.

Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism.

Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo.

Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation.

Extracellular matrix made by bone marrow cells facilitates expansion of marrow-derived mesenchymal progenitor cells and prevents their differentiation into osteoblasts.

Aberrant Phex function in osteoblasts and osteocytes alone underlies murine X-linked hypophosphatemia.

Generation of a conditional null allele for Dmp1 in mouse.

Pathogenic role of Fgf23 in Dmp1-null mice.

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

Studies of the DMP1 57-kDa functional domain both in vivo and in vitro.

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

Do osteocytes contribute to phosphate homeostasis?

Tooth agenesis in a family and homozygous PAX9 mutation in exon 3: a case report.

A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.

Granulin epithelin precursor: a bone morphogenic protein 2-inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis.

Osteocyte Wnt/beta-catenin signaling is required for normal bone homeostasis.

DMP1 C-terminal mutant mice recapture the human ARHR tooth phenotype.

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice.

Expression of FAM20C in the osteogenesis and odontogenesis of mouse.

Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis.

Distribution of small integrin-binding ligand, N-linked glycoproteins (SIBLING) in the articular cartilage of the rat femoral head.

The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment.

Circling behavior developed in Dmp1 null mice is due to bone defects in the vestibular apparatus.

A novel role of periostin in postnatal tooth formation and mineralization.

GEP, a local growth factor, is critical for odontogenesis and amelogenesis.

The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice.

FGF23 in skeletal modeling and remodeling.

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling.

Unique roles of phosphorus in endochondral bone formation and osteocyte maturation.

Roles of DMP1 processing in osteogenesis, dentinogenesis and chondrogenesis.

Evidence for osteocyte regulation of bone homeostasis through RANKL expression.

Meox2Cre-mediated disruption of CSF-1 leads to osteopetrosis and osteocyte defects.

Expression of dentin sialophosphoprotein in non-mineralized tissues.

Expression of dentine sialophosphoprotein in mouse nasal cartilage.

Partial blocking of mouse DSPP processing by substitution of Gly(451)-Asp(452) bond suggests the presence of secondary cleavage site(s).

GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.

Genetic evidence for the vital function of Osterix in cementogenesis.

Phenotypic characterization of osteoarthritic osteocytes from the sclerotic zones: a possible pathological role in subchondral bone sclerosis.

Normocalcemia is maintained in mice under conditions of calcium malabsorption by vitamin D-induced inhibition of bone mineralization.

Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.

Protective roles of DMP1 in high phosphate homeostasis.

Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype.

FAM20C plays an essential role in the formation of murine teeth.

Myelopoiesis is regulated by osteocytes through Gsα-dependent signaling.

Osteoblast lineage-specific effects of notch activation in the skeleton.

Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice.

The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis.

Osteocyte regulation of phosphate homeostasis and bone mineralization underlies the pathophysiology of the heritable disorders of rickets and osteomalacia.

Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration.

Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.

The plastic nature of the human bone-periodontal ligament-tooth fibrous joint.

Cessation of epithelial Bmp signaling switches the differentiation of crown epithelia to the root lineage in a β-catenin-dependent manner.

Failure to process dentin sialophosphoprotein into fragments leads to periodontal defects in mice.

BMP receptor 1A determines the cell fate of the postnatal growth plate.

Steroid-associated hip joint collapse in bipedal emus.

Impact of extracellular matrix derived from osteoarthritis subchondral bone osteoblasts on osteocytes: role of integrinβ1 and focal adhesion kinase signaling cues.

Induced ablation of Bmp1 and Tll1 produces osteogenesis imperfecta in mice.

Beta-galactosidase staining in the skeleton.

Magnesium-containing nanostructured hybrid scaffolds for enhanced dentin regeneration.

Overexpression of Dmp1 fails to rescue the bone and dentin defects in Fam20C knockout mice.

Constitutive nuclear expression of dentin matrix protein 1 fails to rescue the Dmp1-null phenotype.

Twist1- and Twist2-haploinsufficiency results in reduced bone formation.

The Ultrastructural Relationship Between Osteocytes and Dental Implants Following Osseointegration.

Critical role of Bmpr1a in mandibular condyle growth.

A novel way to statistically analyze morphologic changes in Dmp1-null osteocytes.

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures.

Essential role of osterix for tooth root but not crown dentin formation.

Complete pulpodentin complex regeneration by modulating the stiffness of biomimetic matrix.

Osterix controls cementoblast differentiation through downregulation of Wnt-signaling via enhancing DKK1 expression.

Removal of SOST or blocking its product sclerostin rescues defects in the periodontitis mouse model.

Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits.

Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats.

Bmpr1a Signaling in Cartilage Development and Endochondral Bone Formation.

The in vivo role of DMP-1 and serum phosphate on bone mineral composition.

Activation of Receptor Activator of Nuclear Factor-κB Ligand and Matrix Metalloproteinase Production in Periodontal Fibroblasts by Endothelin Signaling.

Critical roles of periostin in the process of orthodontic tooth movement.

Expression of the invertebrate sea urchin P16 protein into mammalian MC3T3 osteoblasts transforms and reprograms them into "osteocyte-like" cells.

Genetic Influences on Temporomandibular Joint Development and Growth.

Expression analysis of α-smooth muscle actin and tenascin-C in the periodontal ligament under orthodontic loading or in vitro culture.

Sclerostin antibody (Scl-Ab) improves osteomalacia phenotype in dentin matrix protein 1(Dmp1) knockout mice with little impact on serum levels of phosphorus and FGF23.

The biological function of type I receptors of bone morphogenetic protein in bone.

Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats.

Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength.

Inactivation of Fam20B in Joint Cartilage Leads to Chondrosarcoma and Postnatal Ossification Defects.

Implant-derived magnesium induces local neuronal production of CGRP to improve bone-fracture healing in rats.

Dmp1 Null Mice Develop a Unique Osteoarthritis-like Phenotype.

Essential Roles of Bone Morphogenetic Protein-1 and Mammalian Tolloid-like 1 in Postnatal Root Dentin Formation.

miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7.