Pradeep Tanwar

In vivo evidence of role of bone morphogenetic protein-4 in the mouse ovary.

Drosophila follicle cells: morphogenesis in an eggshell.

The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival.

Constitutive activation of Beta-catenin in uterine stroma and smooth muscle leads to the development of mesenchymal tumors in mice.

Lin28 promotes transformation and is associated with advanced human malignancies.

Constitutive WNT/beta-catenin signaling in murine Sertoli cells disrupts their differentiation and ability to support spermatogenesis.

Focal Mullerian duct retention in male mice with constitutively activated beta-catenin expression in the Mullerian duct mesenchyme.

Stromal deletion of the APC tumor suppressor in mice triggers development of endometrial cancer.

Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN.

Dynamic expression of bone morphogenetic protein 4 in reproductive organs of female mice.

Adenomatous polyposis coli (APC) is essential for maintaining the integrity of the seminiferous epithelium.

Deletion of tuberous sclerosis 1 in somatic cells of the murine reproductive tract causes female infertility.

Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance.

Altered LKB1/AMPK/TSC1/TSC2/mTOR signaling causes disruption of Sertoli cell polarity and spermatogenesis.

Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1.

The Müllerian inhibiting substance type 2 receptor suppresses tumorigenesis in testes with sustained β-catenin signaling.

PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.

Loss of LKB1 and PTEN tumor suppressor genes in the ovarian surface epithelium induces papillary serous ovarian cancer.

Epithelial Wnt/βcatenin signalling is essential for epididymal coiling.

Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium.

Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development.

Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions.

Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice.

Germ cell-specific sustained activation of Wnt signalling perturbs spermatogenesis in aged mice, possibly through non-coding RNAs.