Hubert Schorle

A subtractive gene expression screen suggests a role of transcription factor AP-2 alpha in control of proliferation and differentiation.

Conditional inactivation of transcription factor AP-2gamma by using the Cre/loxP recombination system.

Transcription factor gene AP-2 gamma essential for early murine development.

Exencephaly in a subset of animals heterozygous for AP-2alpha mutation.

Mutation of the SBF2 gene, encoding a novel member of the myotubularin family, in Charcot-Marie-Tooth neuropathy type 4B2/11p15.

Terminal renal failure in mice lacking transcription factor AP-2 beta.

Dynamic expression of Krüppel-like factor 4 (Klf4), a target of transcription factor AP-2alpha during murine mid-embryogenesis.

Cloning, expression and characterization of the murine Efemp1, a gene mutated in Doyne-Honeycomb retinal dystrophy.

Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5.

Transcription factor AP-2gamma stimulates proliferation and apoptosis and impairs differentiation in a transgenic model.

Starvation response in mouse liver shows strong correlation with life-span-prolonging processes.

Cell type-specific conditional regulation of the c-myc proto-oncogene by combining Cre/loxP recombination and tamoxifen-mediated activation.

Distinct spatial expression patterns of AP-2alpha and AP-2gamma in non-neoplastic human breast and breast cancer.

Towards dissecting the complexity of the AP-1 (activator protein 1) family.

Transcription factor AP-2gamma, a novel marker of gonocytes and seminomatous germ cell tumors.

Dual role of AP-2gamma in ErbB-2-induced mammary tumorigenesis.

A mouse model for cystic biliary dysgenesis in autosomal recessive polycystic kidney disease (ARPKD).

Mice transgenic for NPM-ALK develop non-Hodgkin lymphomas.

Cell-specific deletion of glucosylceramide synthase in brain leads to severe neural defects after birth.

Spatial expression of germ cell markers during maturation of human fetal male gonads: an immunohistochemical study.

The AP-2 family of transcription factors.

Establishment and controlled differentiation of neural crest stem cell lines using conditional transgenesis.

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing.

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo.

Enhanced purification of cell-permeant Cre and germline transmission after transduction into mouse embryonic stem cells.

Gene expression profiling identifies new biological markers of neoplastic germ cells.

Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors.

Sustained platelet-derived growth factor receptor alpha signaling in osteoblasts results in craniosynostosis by overactivating the phospholipase C-gamma pathway.

Autochthonous liver tumors induce systemic T cell tolerance associated with T cell receptor down-modulation.

An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.

Loss of connexin43-mediated gap junctional coupling in the mesenchyme of limb buds leads to altered expression of morphogens in mice.

AP-2alpha regulates migration of GN-11 neurons via a specific genetic programme involving the Axl receptor tyrosine kinase.

AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex.

Critical function of AP-2 gamma/TCFAP2C in mouse embryonic germ cell maintenance.

Loss of transcription factor AP-2gamma/TFAP2C impairs branching morphogenesis of the murine mammary gland.

The transcription factor TCFAP2C/AP-2gamma cooperates with CDX2 to maintain trophectoderm formation.

Interference with activator protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells.

NANOG promoter methylation and expression correlation during normal and malignant human germ cell development.

Lineage conversion of murine extraembryonic trophoblast stem cells to pluripotent stem cells.

Transgenic overexpression of Tcfap2c/AP-2gamma results in liver failure and intestinal dysplasia.

Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.

The seminoma cell line TCam-2 is sensitive to HDAC inhibitor depsipeptide but tolerates various other chemotherapeutic drugs and loss of NANOG expression.

PDGF signalling controls age-dependent proliferation in pancreatic β-cells.

Establishment of a versatile seminoma model indicates cellular plasticity of germ cell tumor cells.

The role of transcription factor Tcfap2c/TFAP2C in trophectoderm development.

Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing.

Valproic acid confers functional pluripotency to human amniotic fluid stem cells in a transgene-free approach.

Fetuin-B, a liver-derived plasma protein is essential for fertilization.

Transcription factor TFAP2C regulates major programs required for murine fetal germ cell maintenance and haploinsufficiency predisposes to teratomas in male mice.

Analysis of TET expression/activity and 5mC oxidation during normal and malignant germ cell development.

Derivation and maintenance of murine trophoblast stem cells under defined conditions.

Reference gene validation for RT-qPCR, a note on different available software packages.

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics.

Co-existence of intact stemness and priming of neural differentiation programs in mES cells lacking Trim71.

Reduced Gene Dosage of Tfap2c Impairs Trophoblast Lineage Differentiation and Alters Maternal Blood Spaces in the Mouse Placenta.

BMP Inhibition in Seminomas Initiates Acquisition of Pluripotency via NODAL Signaling Resulting in Reprogramming to an Embryonal Carcinoma.

Direct Induction of Trophoblast Stem Cells from Murine Fibroblasts.

Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.

SOX2 is essential for in vivo reprogramming of seminoma-like TCam-2 cells to an embryonal carcinoma-like fate.