Philippe J. Sansonetti

Immunogenicity of IpaC-hybrid proteins expressed in the Shigella flexneri 2a vaccine candidate SC602.

Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells.

Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602.

Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility.

Increased interleukin-1 (IL-1) and imbalance between IL-1 and IL-1 receptor antagonist during acute inflammation in experimental Shigellosis.

Induction of necrosis in human neutrophils by Shigella flexneri requires type III secretion, IpaB and IpaC invasins, and actin polymerization.

Parameters underlying successful protection with live attenuated mutants in experimental shigellosis.

CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.

Predominance of serotype-specific mucosal antibody response in Shigella flexneri-infected humans living in an area of endemicity.

Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies.

Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium.

Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2.

The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model.

Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production.

Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology.

Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri.

Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases.

Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis.

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan.

The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2.

Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells.

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

Bacterial invasion: the paradigms of enteroinvasive pathogens.

Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells.

IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis.

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.

War and peace at mucosal surfaces.

Adherence modifies the regulation of gene expression induced by interleukin-10.

Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton.

The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes.

Identification of the critical residues involved in peptidoglycan detection by Nod1.

Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin.

Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice.

PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.

Shigellosis: an old disease in new clothes?

The bacterial weaponry: lessons from Shigella.

The innate signaling of dangers and the dangers of innate signaling.

An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses.

Sensing of bacteria: NOD a lonely job.

Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?

Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain.

Debugging how bacteria manipulate the immune response.

The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction.

Type III secretion effectors of the IpaH family are E3 ubiquitin ligases.

Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy.

Molecular and cellular bases of bacterial virulence: guessing the future episodes of an ongoing saga.

Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella.

Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 DeltaicsA Deltaent Deltafep DeltastxA:HgR oral vaccine SC599 in healthy human adult volunteers.

Rupture, invasion and inflammatory destruction of the intestinal barrier by Shigella: the yin and yang of innate immunity.

Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression.

Host-bacteria homeostasis in the healthy and inflamed gut.

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases.

The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells.

A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection.

Characterisation of early mucosal and neuronal lesions following Shigella flexneri infection in human colon.

Learning tolerance while fighting ignorance.

Framing a concept and an agenda for infectious diseases in EMBO Molecular Medicine.

Breathing life into pathogens: the influence of oxygen on bacterial virulence and host responses in the gastrointestinal tract.

Antigen-specific CD8(+) T cells fail to respond to Shigella flexneri.

The Shigella flexneri type three secretion system effector IpgD inhibits T cell migration by manipulating host phosphoinositide metabolism.

ATP-mediated Erk1/2 activation stimulates bacterial capture by filopodia, which precedes Shigella invasion of epithelial cells.

Design of a specific colonic mucus marker using a human commensal bacterium cell surface domain.

Characterization of the promoter, MxiE box and 5' UTR of genes controlled by the activity of the type III secretion apparatus in Shigella flexneri.

A crypt-specific core microbiota resides in the mouse colon.

Quantitative RT-PCR profiling of the rabbit immune response: assessment of acute Shigella flexneri infection.

Shigella effector IpaB-induced cholesterol relocation disrupts the Golgi complex and recycling network to inhibit host cell secretion.

[Acute intestinal infections: current and upcoming vaccines].

Shigella impairs T lymphocyte dynamics in vivo.

A novel murine model of rhinoscleroma identifies Mikulicz cells, the disease signature, as IL-10 dependent derivatives of inflammatory monocytes.

Epithelial cell proliferation arrest induced by lactate and acetate from Lactobacillus casei and Bifidobacterium breve.

Virulent Shigella flexneri affects secretion, expression, and glycosylation of gel-forming mucins in mucus-producing cells.

Microbiota and the immune system, an amazing mutualism forged by co-evolution.

A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P.

A fluorescent reporter reveals on/off regulation of the Shigella type III secretion apparatus during entry and cell-to-cell spread.

ZapE is a novel cell division protein interacting with FtsZ and modulating the Z-ring dynamics.

New insights into the crosstalk between Shigella and T lymphocytes.

The lacdiNAc-specific adhesin LabA mediates adhesion of Helicobacter pylori to human gastric mucosa.

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity.

Tracking bacterial pathogens with genetically-encoded reporters.

B lymphocytes undergo TLR2-dependent apoptosis upon Shigella infection.

The cytosolic bacterial peptidoglycan sensor Nod2 affords stem cell protection and links microbes to gut epithelial regeneration.

Functional genomics of Lactobacillus casei establishment in the gut.

Rapid 96-well plates DNA extraction and sequencing procedures to identify genome-wide transposon insertion sites in a difficult to lyse bacterium: Lactobacillus casei.

The cofilin phosphatase slingshot homolog 1 (SSH1) links NOD1 signaling to actin remodeling.

Type III secretion system.

TOM1 is a PI5P effector involved in the regulation of endosomal maturation.

Growth and host interaction of mouse segmented filamentous bacteria in vitro.

Pathogen manipulation of B cells: the best defence is a good offence.

An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei.

Mucosal physical and chemical innate barriers: Lessons from microbial evasion strategies.

Functional Genomic Screen Identifies Klebsiella pneumoniae Factors Implicated in Blocking Nuclear Factor κB (NF-κB) Signaling.

Escape of Actively Secreting Shigella flexneri from ATG8/LC3-Positive Vacuoles Formed during Cell-To-Cell Spread Is Facilitated by IcsB and VirA.

Bioimage analysis of Shigella infection reveals targeting of colonic crypts.

Diet and specific microbial exposure trigger features of environmental enteropathy in a novel murine model.

Draft Genome Sequences of Acinetobacter parvus CM11, Acinetobacter radioresistens CM38, and Stenotrophomonas maltophilia BR12, Isolated from Murine Proximal Colonic Tissue.

PI5P Triggers ICAM-1 Degradation in Shigella Infected Cells, Thus Dampening Immune Cell Recruitment.

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity.

Shigella Diversity and Changing Landscape: Insights for the Twenty-First Century.

Histone deacetylase inhibition enhances antimicrobial peptide but not inflammatory cytokine expression upon bacterial challenge.

Shigella flexneri modulates stress granule composition and inhibits stress granule aggregation.

Anoxia and glucose supplementation preserve neutrophil viability and function.

Intestinal Organoids as a Novel Tool to Study Microbes-Epithelium Interactions.

High-fat diet modifies the PPAR-γ pathway leading to disruption of microbial and physiological ecosystem in murine small intestine.

From homeostasis to pathology: decrypting microbe-host symbiotic signals in the intestinal crypt.

Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity.

The infectious hypoxia: occurrence and causes during Shigella infection.

Complete Genome Sequence of Delftia tsuruhatensis CM13 Isolated from Murine Proximal Colonic Tissue.

[Microbiota-intestinal stem cells dialog: a key element for intestinal regeneration].

CD34+ mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury.

Candidate immune biomarkers for radioimmunotherapy.

Moving molecular medicine.

Threonine eliminylation by bacterial phosphothreonine lyases rapidly causes cross-linking of mitogen-activated protein kinase (MAPK) in live cells.

Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world.

Impact of high-fat diet on the intestinal microbiota and small intestinal physiology before and after the onset of obesity.

Shigella sonnei Encodes a Functional T6SS Used for Interbacterial Competition and Niche Occupancy.

Comparative genomic analysis of Acinetobacter strains isolated from murine colonic crypts.

Injection of T3SS effectors not resulting in invasion is the main targeting mechanism of toward human lymphocytes.

Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance.

Identification of novel substrates of Shigella T3SA through analysis of its virulence plasmid-encoded secretome.

Editorial: Editorial for the virtual issue on microbiome.

Colorectal cancer specific conditions promote gut colonization.

Pathogens, microbiome and the host: emergence of the ecological Koch's postulates.

Rhinoscleroma pathogenesis: The type K3 capsule of Klebsiella rhinoscleromatis is a virulence factor not involved in Mikulicz cells formation.

Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.

MUB Binds to Lactoferrin and Stands as a Specific Neutrophil Marker.

Measles 2018: a tale of two anniversaries.

Human Enteric α-Defensin 5 Promotes Shigella Infection by Enhancing Bacterial Adhesion and Invasion.

Identifying the etiology and pathophysiology underlying stunting and environmental enteropathy: study protocol of the AFRIBIOTA project.

Stunted childhood growth is associated with decompartmentalization of the gastrointestinal tract and overgrowth of oropharyngeal taxa.

Disentangling Host-Microbiota Regulation of Lipid Secretion by Enterocytes: Insights from Commensals and .

Shigella and Enteroinvasive Escherichia Coli.

Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3.

Expression of the human antimicrobial peptide β-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells.

Pathogenesis: New Insights through Advanced Methodologies.

-mediated immunosuppression in the human gut: subversion extends from innate to adaptive immune responses.

promotes major alteration of gut epithelial physiology and tissue invasion by shutting off host intracellular transport.

Crypt- and Mucosa-Associated Core Microbiotas in Humans and Their Alteration in Colon Cancer Patients.

Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization.

Mapping of Shigella flexneri's tissue distribution and type III secretion apparatus activity during infection of the large intestine of guinea pigs.

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures.

Intracellular offspring released from SFB filaments are flagellated.

Innate immune receptor NOD2 mediates LGR5 intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation.

Shigella impairs human T lymphocyte responsiveness by hijacking actin cytoskeleton dynamics and T cell receptor vesicular trafficking.

Fermentation Products of Commensal Bacteria Alter Enterocyte Lipid Metabolism.

Study of the Operon Coding a Two-Component System and a Putative L,D-Carboxypeptidase in .

COVID-19, chronicle of an expected pandemic.

Immunoglobulin recognition of fecal bacteria in stunted and non-stunted children: findings from the Afribiota study.

Survival of the Wealthiest?

High prevalence of intestinal parasite infestations among stunted and control children aged 2 to 5 years old in two neighborhoods of Antananarivo, Madagascar.

Structural Insights of Translocator IpaB and Its Chaperone IpgC in Solution.

Vitamin C levels in a Central-African mother-infant cohort: Does hypovitaminosis C increase the risk of enteric infections?

Cytokine receptor cluster size impacts its endocytosis and signaling.