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Department of Hematology
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Expression, purification, and crystallization of neuro- and cytoglobin.
Methods in enzymology , 2008 | Pubmed ID: 18237642
Ultrafast heme-residue bond formation in six-coordinate heme proteins: implications for functional ligand exchange.
Biochemistry May, 2008 | Pubmed ID: 18454557
Pseudo-merohedral twinning in monoclinic crystals of wild-type human brain neuroglobin.
Acta crystallographica. Section D, Biological crystallography Apr, 2009 | Pubmed ID: 19307722
Neuroglobin and prion cellular localization: investigation of a potential interaction.
Journal of molecular biology May, 2009 | Pubmed ID: 19327369
Heme ligand binding properties and intradimer interactions in the full-length sensor protein dos from Escherichia coli and its isolated heme domain.
The Journal of biological chemistry Dec, 2009 | Pubmed ID: 19864414
Cytoglobin conformations and disulfide bond formation.
The FEBS journal Jun, 2010 | Pubmed ID: 20553503
Electron transfer function versus oxygen delivery: a comparative study for several hexacoordinated globins across the animal kingdom.
PloS one , 2011 | Pubmed ID: 21674044
Downregulation of apoptosis-inducing factor in Harlequin mice induces progressive and severe optic atrophy which is durably prevented by AAV2-AIF1 gene therapy.
Brain : a journal of neurology Jan, 2012 | Pubmed ID: 22120150
Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity.
Biochimica et biophysica acta Dec, 2012 | Pubmed ID: 23036890
Neuroglobins, pivotal proteins associated with emerging neural systems and precursors of metazoan globin diversity.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23288852
Neuroglobin involvement in visual pathways through the optic nerve.
Biochimica et biophysica acta Sep, 2013 | Pubmed ID: 23639750
Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.
Molecular therapy : the journal of the American Society of Gene Therapy Jun, 2014 | Pubmed ID: 24622090
The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity.
Acta crystallographica. Section D, Biological crystallography Apr, 2014 | Pubmed ID: 24699645
The chimerical and multifaceted marine acoel Symsagittifera roscoffensis: from photosymbiosis to brain regeneration.
Frontiers in microbiology , 2014 | Pubmed ID: 25324833
Genotypic and phenotypic characterization of P23H line 1 rat model.
PloS one , 2015 | Pubmed ID: 26009893
Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss.
Molecular therapy. Methods & clinical development , 2015 | Pubmed ID: 26029714
Neuroglobin Can Prevent or Reverse Glaucomatous Progression in DBA/2J Mice.
Molecular therapy. Methods & clinical development Jun, 2017 | Pubmed ID: 28540323
St. Jude Children's Research Hospital
Lauren A. Biwer1,2,
Christophe Lechauve3,
Sheri Vanhoose4,
Mitchell J. Weiss3,
Brant E. Isakson1,2
1Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine,
2Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine,
3Department of Hematology, St. Jude Children's Research Hospital,
4Research Histology Core, University of Virginia School of Medicine
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