Howard E. Gendelman

Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia.

Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis.

Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis.

Macrophages, chemokines and neuronal injury in HIV-1-associated dementia.

HIV-1-associated dementia: a basic science and clinical perspective.

HIV-1-associated dementia: a metabolic encephalopathy perpetrated by virus-infected and immune-competent mononuclear phagocytes.

Neural immunity: Friend or foe?

Murine models for human immunodeficiency virus type 1-associated dementia: the development of new treatment testing paradigms.

Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia.

C1q-calreticulin induced oxidative neurotoxicity: relevance for the neuropathogenesis of Alzheimer's disease.

Activation of NR1a/NR2B receptors by monocyte-derived macrophage secretory products: implications for human immunodeficiency virus type one-associated dementia.

Neuronal injury regulates fractalkine: relevance for HIV-1 associated dementia.

Tracking superparamagnetic iron oxide labeled monocytes in brain by high-field magnetic resonance imaging.

Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia.

Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function.

Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis.

Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection.

Molecular characterization of a putative antiretroviral transcriptional factor, OTK18.

Proteomic fingerprinting of HIV-1-infected human monocyte-derived macrophages: a preliminary report.

TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia.

Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study.

Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis.

Advances in neuroimaging for HIV-1 associated neurological dysfunction: clues to the diagnosis, pathogenesis and therapeutic monitoring.

OTK18 expression in brain mononuclear phagocytes parallels the severity of HIV-1 encephalitis.

Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis.

Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease.

Memantine protects hippocampal neuronal function in murine human immunodeficiency virus type 1 encephalitis.

Diminished matrix metalloproteinase 9 secretion in human immunodeficiency virus-infected mononuclear phagocytes: modulation of innate immunity and implications for neurological disease.

Infections of the nervous system.

Neuroprotective strategies for HIV-1 associated dementia.

Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.

Quantitative 1H magnetic resonance spectroscopic imaging determines therapeutic immunization efficacy in an animal model of Parkinson's disease.

Proteomic fingerprints distinguish microglia, bone marrow, and spleen macrophage populations.

Overexpression of monocyte chemotactic protein-1/CCL2 in beta-amyloid precursor protein transgenic mice show accelerated diffuse beta-amyloid deposition.

Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects.

Development of a rapid autopsy program for studies of brain immunity.

Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis.

Isolation, propagation, and HIV-1 infection of monocyte-derived macrophages and recovery of virus from brain and cerebrospinal fluid.

Isolation and HIV-1 infection of primary human microglia from fetal and adult tissue.

Macrophage-induced inflammation affects hippocampal plasticity and neuronal development in a murine model of HIV-1 encephalitis.

Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis.

HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration across blood-brain barrier: implication for viral neuropathogenesis.

Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brain.

Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery.

Human immunodeficiency virus-mononuclear phagocyte interactions: emerging avenues of biomarker discovery, modes of viral persistence and disease pathogenesis.

Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery.

HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta.

Laboratory investigations for the morphologic, pharmacokinetic, and anti-retroviral properties of indinavir nanoparticles in human monocyte-derived macrophages.

A functional transsulfuration pathway in the brain links to glutathione homeostasis.

Monocyte differentiation, activation, and mycobacterial killing are linked to transsulfuration-dependent redox metabolism.

Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis.

Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.

Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease.

Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice.

Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS.

Investigating the human immunodeficiency virus type 1-infected monocyte-derived macrophage secretome.

HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia.

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease.

Genomic and proteomic microglial profiling: pathways for neuroprotective inflammatory responses following nerve fragment clearance and activation.

Cytoskeletal protein transformation in HIV-1-infected macrophage giant cells.

Glatiramer acetate immunization induces specific antibody and cytokine responses in ALS patients.

Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease.

Oxidative stress and the pathogenesis of neurodegenerative disorders.

A macrophage-nanozyme delivery system for Parkinson's disease.

Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis.

Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment.

T cell independent mechanism for copolymer-1-induced neuroprotection.

CSF proteomic fingerprints for HIV-associated cognitive impairment.

Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.

STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier.

Nitrated alpha-synuclein-activated microglial profiling for Parkinson's disease.

Debate: "is increasing neuroinflammation beneficial for neural repair?".

Nanotechnology: a focus on nanoparticles as a drug delivery system.

Biomarkers, laboratory, and animal models for the design and development of adjunctive therapies for HIV-1 dementia and other neuroinflammatory disorders.

Glycogen synthase kinase 3 beta (GSK-3 beta) as a therapeutic target in neuroAIDS.

The Journal of Neuroimmune Pharmacology reaches its stride.

Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis.

Neuroinflammation, Oxidative Stress and the Pathogenesis of Parkinson's Disease.

Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.

Nitrated alpha-synuclein and microglial neuroregulatory activities.

The promise and perils of CNS drug delivery: a video debate.

Disseminating research discovery through an interactive video: a paradigm shift for journal publication.

Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk.

HIV-1-infected astrocytes and the microglial proteome.

Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.

Ingress of blood-borne macrophages across the blood-brain barrier in murine HIV-1 encephalitis.

Multidimensional protein fractionation using ProteomeLab PF 2D for profiling amyotrophic lateral sclerosis immunity: A preliminary report.

The neuropathogenesis of HIV-1 infection.

Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration.

Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles.

Innate and adaptive immunity for the pathobiology of Parkinson's disease.

Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration.

AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.

Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.

Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.

HIV-1 transforms the monocyte plasma membrane proteome.

Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells.

CD 4+ T cells in the pathobiology of neurodegenerative disorders.

Planning Future Strategies for Domestic and International NeuroAIDS Research, July 24-25, 2008.

4-Aminopyridine improves spatial memory in a murine model of HIV-1 encephalitis.

Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.

Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders.

Neurodegenerative disorders and nanoformulated drug development.

NanoART, neuroAIDS and CNS drug delivery.

CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.

A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection.

Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.

NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery.

Neuroprotective activities of CEP-1347 in models of neuroAIDS.

HIV-1 neuroimmunity in the era of antiretroviral therapy.

Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders.

Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers.

Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.

Nanoformulated antiretroviral drug combinations extend drug release and antiretroviral responses in HIV-1-infected macrophages: implications for neuroAIDS therapeutics.

Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.

CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.

Macrophage delivery of therapeutic nanozymes in a murine model of Parkinson's disease.

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases.

Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS.

Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques.

Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis.

Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.

Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage.

Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages.

Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants.

Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage.

Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles.

Cell-mediated drug delivery.

Loss of neuronal integrity during progressive HIV-1 infection of humanized mice.

Macrophage endocytic trafficking of antiretroviral nanoparticles.

Murine Motor and Behavior Functional Evaluations for Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Intoxication.

Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells.

Pulsed stable isotope labeling of amino acids in cell culture uncovers the dynamic interactions between HIV-1 and the monocyte-derived macrophage.

Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network.

Methamphetamine-Associated Psychosis.

Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses.

Proteomic biosignatures for monocyte-macrophage differentiation.

Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection.

Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques.

Landmark optimization using local curvature for point-based nonlinear rodent brain image registration.

Neuroprotective activities of regulatory T cells.

Pathways towards an effective immunotherapy for Parkinson's disease.

Cell delivery of therapeutic nanoparticles.

Immunization strategies for Parkinson's disease.

Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

Blood-borne macrophage-neural cell interactions hitchhike endosome networks for cell-based nanozyme brain delivery.

Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.

Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease.

Rodent models for HIV-associated neurocognitive disorders.

Inflammation and adaptive immunity in Parkinson's disease.