Laboratory of Brain and Neurological Disorders,
Graduate School of Pharmaceutical Sciences,
Laboratory of Neuropathology and Neuroscience,
Laboratory of Brain and Neurological Disorders, Graduate School of Pharmaceutical Sciences,
Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences
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Association of active gamma-secretase complex with lipid rafts.
Journal of lipid research May, 2005 | Pubmed ID: 15716592
gamma-secretase as a therapeutic target for treatment of Alzheimer's disease.
Current pharmaceutical design , 2006 | Pubmed ID: 16472155
C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester).
The Journal of biological chemistry May, 2006 | Pubmed ID: 16569643
Presenilin-dependent intramembrane cleavage of ephrin-B1.
Molecular neurodegeneration Jun, 2006 | Pubmed ID: 16930449
Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2006 | Pubmed ID: 17108181
Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate.
The Journal of biological chemistry Apr, 2007 | Pubmed ID: 17329245
At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism.
Naunyn-Schmiedeberg's archives of pharmacology Jun, 2008 | Pubmed ID: 18038124
The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 2008 | Pubmed ID: 18550769
S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19028695
Secretase inhibitors and modulators for Alzheimer's disease treatment.
Expert review of neurotherapeutics May, 2009 | Pubmed ID: 19402777
Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19684016
[Biology and pathobiology of the intramembrane proteolysis by gamma-secretase].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Oct, 2009 | Pubmed ID: 19827607
Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker.
Bioorganic & medicinal chemistry letters Dec, 2009 | Pubmed ID: 19892551
Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase.
The Journal of biological chemistry Jun, 2010 | Pubmed ID: 20418378
[Molecular targeted therapy in Alzheimer disease].
Nihon rinsho. Japanese journal of clinical medicine Oct, 2010 | Pubmed ID: 20954338
[Structure and function analysis of gamma-secretase complex toward development of therapeutics for Alzheimer's disease].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme Sep, 2009 | Pubmed ID: 21089607
Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2010 | Pubmed ID: 21106832
Selectivity to amyloid-β precursor protein cleavage provides hope against Alzheimer's.
Alzheimer's research & therapy Mar, 2011 | Pubmed ID: 21418547
BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.
The Journal of neuroscience : the official journal of the Society for Neuroscience May, 2011 | Pubmed ID: 21543615
Three-dimensional structure of the signal peptide peptidase.
The Journal of biological chemistry Jul, 2011 | Pubmed ID: 21636854
Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.
The EMBO journal Oct, 2011 | Pubmed ID: 22002539
Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein.
The Journal of biological chemistry Jul, 2012 | Pubmed ID: 22689582
Activity-dependent proteolytic cleavage of neuroligin-1.
Neuron Oct, 2012 | Pubmed ID: 23083742
[Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity].
Rinsho shinkeigaku = Clinical neurology , 2012 | Pubmed ID: 23196551
Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1.
Biochemistry Jan, 2013 | Pubmed ID: 23210549
Structural biology of presenilins and signal peptide peptidases.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23585568
FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons.
PloS one , 2013 | Pubmed ID: 23667698
γ -Secretase Pharmacology: What Pharmacology Will Work for Alzheimer's Disease?
International journal of Alzheimer's disease , 2013 | Pubmed ID: 23710414
Protein trafficking and maturation regulate intramembrane proteolysis.
Biochimica et biophysica acta Dec, 2013 | Pubmed ID: 23770323
Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana.
BMC biochemistry Jul, 2013 | Pubmed ID: 23829174
Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.
Structure (London, England : 1993) Jan, 2014 | Pubmed ID: 24210759
[Alzheimer disease: experimental approaches to genetic and environmental risk factors].
Rinsho shinkeigaku = Clinical neurology , 2013 | Pubmed ID: 24291845
Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation.
Angewandte Chemie (International ed. in English) Jan, 2014 | Pubmed ID: 24339209
Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation.
Molecular neurodegeneration Jan, 2014 | Pubmed ID: 24410857
Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase.
Nature communications Feb, 2014 | Pubmed ID: 24577224
Allosteric regulation of γ-secretase activity by a phenylimidazole-type γ-secretase modulator.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2014 | Pubmed ID: 25009180
Molecular mechanism of intramembrane proteolysis by γ-secretase.
Journal of biochemistry Oct, 2014 | Pubmed ID: 25108625
Synthetic ceramide analogues increase amyloid-β 42 production by modulating γ-secretase activity.
Biochemical and biophysical research communications Feb, 2015 | Pubmed ID: 25545059
Cooperative roles of hydrophilic loop 1 and the C-terminus of presenilin 1 in the substrate-gating mechanism of γ-secretase.
The Journal of neuroscience : the official journal of the Society for Neuroscience Feb, 2015 | Pubmed ID: 25673856
Suppressor Mutations for Presenilin 1 Familial Alzheimer Disease Mutants Modulate γ-Secretase Activities.
The Journal of biological chemistry Jan, 2016 | Pubmed ID: 26559975
Conformational Changes in Transmembrane Domain 4 of Presenilin 1 Are Associated with Altered Amyloid-β 42 Production.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2016 | Pubmed ID: 26818522
Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.
Journal of neurochemistry 05, 2016 | Pubmed ID: 26896628
A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons.
Scientific reports Apr, 2016 | Pubmed ID: 27040987
BIN1 regulates BACE1 intracellular trafficking and amyloid-β production.
Human molecular genetics Jul, 2016 | Pubmed ID: 27179792
Cell-free methods to produce structurally intact mammalian membrane proteins.
Scientific reports Jul, 2016 | Pubmed ID: 27465719
Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo.
Human molecular genetics Sep, 2016 | Pubmed ID: 27466196
Molecular mechanisms of the genetic risk factors in pathogenesis of Alzheimer disease.
Frontiers in bioscience (Landmark edition) Jan, 2017 | Pubmed ID: 27814610
Probing the Structure and Function Relationships of Presenilin by Substituted-Cysteine Accessibility Method.
Methods in enzymology , 2017 | Pubmed ID: 28065263
Aberrant proteolytic processing and therapeutic strategies in Alzheimer disease.
Advances in biological regulation 05, 2017 | Pubmed ID: 28082052
Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking.
European journal of pharmacology Mar, 2017 | Pubmed ID: 28167259
The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif.
Acta crystallographica. Section F, Structural biology communications 03, 2017 | Pubmed ID: 28291748
Dysregulated Metabolism of the Amyloid-β Protein and Therapeutic Approaches in Alzheimer Disease.
Journal of cellular biochemistry Dec, 2017 | Pubmed ID: 28488760
Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease.
Journal of Alzheimer's disease : JAD , 2017 | Pubmed ID: 28550247
Memantine inhibits β-amyloid aggregation and disassembles preformed β-amyloid aggregates.
Biochemical and biophysical research communications Nov, 2017 | Pubmed ID: 28917837
Activation of γ-secretase trimming activity by topological changes of transmembrane domain 1 of presenilin 1.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2017 | Pubmed ID: 29118109