Thomas Rich

Cellular mechanisms underlying prostaglandin-induced transient cAMP signals near the plasma membrane of HEK-293 cells.

Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.

Receptor reserve reflects differential intrinsic efficacy associated with opioid diastereomers.

Quantitative modeling of GRK-mediated beta2AR regulation.

PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblasts.

A2B adenosine receptors inhibit superoxide production from mitochondrial complex I in rabbit cardiomyocytes via a mechanism sensitive to Pertussis toxin.

Inactivation of multidrug resistance proteins disrupts both cellular extrusion and intracellular degradation of cAMP.

All preconditioning-related G protein-coupled receptors can be demonstrated in the rabbit cardiomyocyte.

Hyperspectral imaging microscopy for identification and quantitative analysis of fluorescently-labeled cells in highly autofluorescent tissue.

Assessment of cellular mechanisms contributing to cAMP compartmentalization in pulmonary microvascular endothelial cells.

A-kinase anchoring proteins regulate compartmentalized cAMP signaling in airway smooth muscle.

Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.

Feedback regulation of cone cyclic nucleotide channels by phosphoinositides. Focus on "CNGA3 achromatopsia-associated mutation potentiates the phosphoinositide sensitivity of cone photoreceptor CNG channels by altering intersubunit interactions".

Hyperspectral imaging of FRET-based cGMP probes.

An approach for characterizing and comparing hyperspectral microscopy systems.

Assessing FRET using spectral techniques.

Thin-film tunable filters for hyperspectral fluorescence microscopy.

Can we decipher the information content contained within cyclic nucleotide signals?

Excitation-scanning hyperspectral imaging microscope.

β-Agonist-mediated relaxation of airway smooth muscle is protein kinase A-dependent.

FRET: signals hidden within the noise.

Sodium entry through endothelial store-operated calcium entry channels: regulation by Orai1.

Automated image analysis of FRET signals for subcellular cAMP quantification.

Channel-based reporters for cAMP detection.

Estimating the magnitude of near-membrane PDE4 activity in living cells.

Overcoming limitations of FRET measurements.

Hyperspectral imaging fluorescence excitation scanning for colon cancer detection.

A theoretical-experimental methodology for assessing the sensitivity of biomedical spectral imaging platforms, assays, and analysis methods.

Human ASIC1a mediates stronger acid-induced responses as compared with mouse ASIC1a.

Spectral imaging of FRET-based sensors reveals sustained cAMP gradients in three spatial dimensions.

Identifying molecular contributors to autofluorescence of neoplastic and normal colon sections using excitation-scanning hyperspectral imaging.

Label-free spectroscopic tissue characterization using fluorescence excitation-scanning spectral imaging.

Applications and assessment of an excitation-scanning hyperspectral imaging system.

cAMP signaling primes lung endothelial cells to activate caspase-1 during infection.

Development of an endothelial cell-restricted transgenic reporter rat: a resource for physiological studies of vascular biology.

Milestones in the development and implementation of FRET-based sensors of intracellular signals: A biological perspective of the history of FRET.

Excitation-scanning hyperspectral video endoscopy: enhancing the light at the end of the tunnel.

Optical simulations for determining efficacy of new light source designs for excitation-scanning high-speed hyperspectral imaging systems.

Comparison of spectral FRET microscopy approaches for single-cell analysis.

Design of a modified endoscope illuminator for spectral imaging of colorectal tissues.

Hyperspectral imaging microscopy for measurement of localized second messenger signals in single cells.

A Spherical Mirror-based Illumination System for Fluorescence Excitation-Scanning Hyperspectral Imaging.

Optimization of Light Transmission through an Excitation-scan Hyperspectral Mirror Array System.

Optimizing channel selection for excitation-scanning hyperspectral imaging.

Hyperspectral imaging fluorescence excitation scanning (HIFEX) microscopy for live cell imaging.

Hyperspectral imaging fluorescence excitation scanning spectral characteristics of remodeled mouse arteries.

Spectral Illumination System Utilizing Spherical Reflection Optics.

Tunable thin-film optical filters for hyperspectral microscopy.

Three dimensional measurement of cAMP gradients using hyperspectral confocal microscopy.

Comparing Methods for Analysis of Biomedical Hyperspectral Image Data.

5D imaging approaches reveal the formation of distinct intracellular cAMP spatial gradients.

LED-based endoscopic light source for spectral imaging.

Excitation-Scanning Hyperspectral Imaging as a Means to Discriminate Various Tissues Types.

Optimization and applications of an excitation-scanning hyperspectral imaging system.

Endoscopic hyperspectral imaging: light guide optimization for spectral light source.

Colorectal cancer detection by hyperspectral imaging using fluorescence excitation scanning.

Demystifying autofluorescence with excitation-scanning hyperspectral imaging.

Sensitivity analysis of a multibranched light guide for real time hyperspectral imaging systems.

Excitation-Scanning Hyperspectral Imaging System for Microscopic and Endoscopic Applications.

Excitation-scan Mirror Array System Advancements to Hyperspectral Imaging Applications.

Feasibility for detection of autofluorescent signatures in rat organs using a novel excitation-scanning hyperspectral imaging system.

Hyperspectral Imaging Fluorescence Excitation Scanning for Detecting Colorectal Cancer: Pilot Study.

Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β -adrenergic receptor.