Laboratory of Molecular Physiology,
NHLBI,
Cell and Developmental Biology Center,
National Heart,
Lung and Blood Institute,
Laboratory of Molecular Physiology, NHLBI,
Laboratory of Molecular Physiology, Cell and Developmental Biology Center, National Heart, Lung and Blood Institute
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A myosin III from Limulus eyes is a clock-regulated phosphoprotein.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jun, 1998 | Pubmed ID: 9614231
Analysis of the regulatory phosphorylation site in Acanthamoeba myosin IC by using site-directed mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1998 | Pubmed ID: 9860946
Myosin-I nomenclature.
The Journal of cell biology Nov, 2001 | Pubmed ID: 11724811
Identification of an organelle receptor for myosin-Va.
Nature cell biology Apr, 2002 | Pubmed ID: 11887186
Rab27a is an essential component of melanosome receptor for myosin Va.
Molecular biology of the cell May, 2002 | Pubmed ID: 12006666
Mutations in human nonmuscle myosin IIA found in patients with May-Hegglin anomaly and Fechtner syndrome result in impaired enzymatic function.
The Journal of biological chemistry Nov, 2002 | Pubmed ID: 12237319
The prepower stroke conformation of myosin V.
The Journal of cell biology Dec, 2002 | Pubmed ID: 12499355
Kinetic mechanism of non-muscle myosin IIB: functional adaptations for tension generation and maintenance.
The Journal of biological chemistry Jul, 2003 | Pubmed ID: 12704189
Neck length and processivity of myosin V.
The Journal of biological chemistry Aug, 2003 | Pubmed ID: 12740393
Utility of genetic screening in hypertrophic cardiomyopathy: prevalence and significance of novel and double (homozygous and heterozygous) beta-myosin mutations.
Genetic testing , 2003 | Pubmed ID: 12820698
Functional divergence of human cytoplasmic myosin II: kinetic characterization of the non-muscle IIA isoform.
The Journal of biological chemistry Oct, 2003 | Pubmed ID: 12847096
Regulated conformation of myosin V.
The Journal of biological chemistry Jan, 2004 | Pubmed ID: 14634000
Trifluoperazine inhibits the MgATPase activity and in vitro motility of conventional and unconventional myosins.
Journal of muscle research and cell motility , 2003 | Pubmed ID: 14870973
Two-headed binding of the unphosphorylated nonmuscle heavy meromyosin.ADP complex to actin.
Biochemistry Apr, 2004 | Pubmed ID: 15065866
Mechanism of blebbistatin inhibition of myosin II.
The Journal of biological chemistry Aug, 2004 | Pubmed ID: 15205456
Nanometer localization of single green fluorescent proteins: evidence that myosin V walks hand-over-hand via telemark configuration.
Biophysical journal Sep, 2004 | Pubmed ID: 15345556
Specificity of blebbistatin, an inhibitor of myosin II.
Journal of muscle research and cell motility , 2004 | Pubmed ID: 15548862
Fifty years of contractility research post sliding filament hypothesis.
Journal of muscle research and cell motility , 2004 | Pubmed ID: 15630612
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
Biochemistry Jan, 2005 | Pubmed ID: 15641783
Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia.
Nature cell biology Feb, 2005 | Pubmed ID: 15654330
Mechanism of action of myosin X, a membrane-associated molecular motor.
The Journal of biological chemistry Apr, 2005 | Pubmed ID: 15705568
Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
The Journal of biological chemistry Jun, 2005 | Pubmed ID: 15845534
Myosin V from Drosophila reveals diversity of motor mechanisms within the myosin V family.
The Journal of biological chemistry Aug, 2005 | Pubmed ID: 15980429
Myosin VIIB from Drosophila is a high duty ratio motor.
The Journal of biological chemistry Sep, 2005 | Pubmed ID: 16055438
Step-size is determined by neck length in myosin V.
Biochemistry Dec, 2005 | Pubmed ID: 16331980
Walking with myosin V.
Current opinion in cell biology Feb, 2006 | Pubmed ID: 16378722
Dimerized Drosophila myosin VIIa: a processive motor.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2006 | Pubmed ID: 16585515
The cargo-binding domain regulates structure and activity of myosin 5.
Nature Jul, 2006 | Pubmed ID: 16838021
In vitro reconstitution of a transport complex containing Rab27a, melanophilin and myosin Va.
FEBS letters Oct, 2006 | Pubmed ID: 17045265
Loop 2 of limulus myosin III is phosphorylated by protein kinase A and autophosphorylation.
Biochemistry Apr, 2007 | Pubmed ID: 17367164
Diversity of structural behavior in vertebrate conventional myosins complexed with actin.
Journal of molecular biology May, 2007 | Pubmed ID: 17433365
Myo4p is a monomeric myosin with motility uniquely adapted to transport mRNA.
The Journal of cell biology Sep, 2007 | Pubmed ID: 17893244
The B2 alternatively spliced isoform of nonmuscle myosin II-B lacks actin-activated MgATPase activity and in vitro motility.
Biochemical and biophysical research communications Apr, 2008 | Pubmed ID: 18060863
Calcium and cargoes as regulators of myosin 5a activity.
Biochemical and biophysical research communications Apr, 2008 | Pubmed ID: 18060865
Mutation spectrum of MYO7A and evaluation of a novel nonsyndromic deafness DFNB2 allele with residual function.
Human mutation Apr, 2008 | Pubmed ID: 18181211
Folding and regulation in myosins II and V.
Journal of muscle research and cell motility , 2007 | Pubmed ID: 18427938
The small molecule tool (S)-(-)-blebbistatin: novel insights of relevance to myosin inhibitor design.
Organic & biomolecular chemistry Jun, 2008 | Pubmed ID: 18528569
Switch 1 mutation S217A converts myosin V into a low duty ratio motor.
The Journal of biological chemistry Jan, 2009 | Pubmed ID: 19008235
An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
The Journal of biological chemistry Apr, 2009 | Pubmed ID: 19240025
A FERM domain autoregulates Drosophila myosin 7a activity.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2009 | Pubmed ID: 19255446
Extensibility of the extended tail domain of processive and nonprocessive myosin V molecules.
Biophysical journal Dec, 2009 | Pubmed ID: 20006949
Influence of lever structure on myosin 5a walking.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2010 | Pubmed ID: 20133809
Direct observation of the myosin-Va power stroke and its reversal.
Nature structural & molecular biology May, 2010 | Pubmed ID: 20418880
Nonmuscle myosin IIA with a GFP fused to the N-terminus of the regulatory light chain is regulated normally.
Journal of muscle research and cell motility Sep, 2010 | Pubmed ID: 20711642
Myosin VI and its binding partner optineurin are involved in secretory vesicle fusion at the plasma membrane.
Molecular biology of the cell Jan, 2011 | Pubmed ID: 21148290
The kinetic mechanism of mouse myosin VIIA.
The Journal of biological chemistry Mar, 2011 | Pubmed ID: 21212272
Drosophila melanogaster myosin-18 represents a highly divergent motor with actin tethering properties.
The Journal of biological chemistry Jun, 2011 | Pubmed ID: 21498886
Light-triggered myosin activation for probing dynamic cellular processes.
Angewandte Chemie (International ed. in English) Jun, 2011 | Pubmed ID: 21542072
Dynein struts its stuff.
Nature structural & molecular biology Jun, 2011 | Pubmed ID: 21642959
Nucleotide pyrophosphatase employs a P-loop-like motif to enhance catalytic power and NDP/NTP discrimination.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2011 | Pubmed ID: 21831832
Myosin motor proteins are involved in the final stages of the secretory pathways.
Biochemical Society transactions Oct, 2011 | Pubmed ID: 21936774
Regulation of myosin 5a and myosin 7a.
Biochemical Society transactions Oct, 2011 | Pubmed ID: 21936778
Walking to work: roles for class V myosins as cargo transporters.
Nature reviews. Molecular cell biology Dec, 2011 | Pubmed ID: 22146746
Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2012 | Pubmed ID: 22393000
Dynamic exchange of myosin VI on endocytic structures.
The Journal of biological chemistry Nov, 2012 | Pubmed ID: 22992744
Kinetic characterization of nonmuscle myosin IIb at the single molecule level.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23148220
Mammalian myosin-18A, a highly divergent myosin.
The Journal of biological chemistry Mar, 2013 | Pubmed ID: 23382379
Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.
The Journal of biological chemistry May, 2013 | Pubmed ID: 23530050
Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Aug, 2013 | Pubmed ID: 23657818
Kinetic characterization of the ATPase and actin-activated ATPase activities of Acanthamoeba castellanii myosin-2.
The Journal of biological chemistry Sep, 2013 | Pubmed ID: 23897814
Actin structure-dependent stepping of myosin 5a and 10 during processive movement.
PloS one , 2013 | Pubmed ID: 24069366
Characterization of three full-length human nonmuscle myosin II paralogs.
The Journal of biological chemistry Nov, 2013 | Pubmed ID: 24072716
To understand muscle you must take it apart.
Frontiers in physiology , 2014 | Pubmed ID: 24653704
Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.
Proceedings of the National Academy of Sciences of the United States of America May, 2014 | Pubmed ID: 24753602
Regulation of nonmuscle myosin II by tropomyosin.
Biochemistry Jun, 2014 | Pubmed ID: 24873380
Use of fluorescent techniques to study the in vitro movement of myosins.
Experientia supplementum (2012) , 2014 | Pubmed ID: 25095996
Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2014 | Pubmed ID: 25114250
Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogaster.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Apr, 2015 | Pubmed ID: 25636739
Four things to know about myosin light chains as reporters for non-muscle myosin-2 dynamics in live cells.
Cytoskeleton (Hoboken, N.J.) Feb, 2015 | Pubmed ID: 25712372
Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy.
eLife Mar, 2015 | Pubmed ID: 25748137
Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.
Current biology : CB Mar, 2015 | Pubmed ID: 25754640
Myosin light chains: Teaching old dogs new tricks.
Bioarchitecture , 2014 | Pubmed ID: 26155737
Various Themes of Myosin Regulation.
Journal of molecular biology 05, 2016 | Pubmed ID: 26827725
The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.
The Journal of biological chemistry Apr, 2016 | Pubmed ID: 26893376
Kinetic Adaptations of Myosins for Their Diverse Cellular Functions.
Traffic (Copenhagen, Denmark) 08, 2016 | Pubmed ID: 26929436
Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors.
Journal of molecular biology 05, 2016 | Pubmed ID: 27113061
Mammalian Nonmuscle Myosin II Binds to Anionic Phospholipids with Concomitant Dissociation of the Regulatory Light Chain.
The Journal of biological chemistry Nov, 2016 | Pubmed ID: 27697842
Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells.
Molecular biology of the cell 01, 2017 | Pubmed ID: 27881665
non-muscle myosin II motor activity determines the rate of tissue folding.
eLife 12, 2016 | Pubmed ID: 28035903
Re-evaluating the roles of myosin 18Aα and F-actin in determining Golgi morphology.
Cytoskeleton (Hoboken, N.J.) May, 2017 | Pubmed ID: 28329908
Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II.
Proceedings of the National Academy of Sciences of the United States of America 08, 2017 | Pubmed ID: 28739905
Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease.
The Journal of biological chemistry 11, 2017 | Pubmed ID: 28882893
Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.
eLife 12, 2017 | Pubmed ID: 29256864
Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties.
eLife 02, 2018 | Pubmed ID: 29419377
Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level.
Nature communications 07, 2018 | Pubmed ID: 30030431
Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments.
The Journal of biological chemistry 09, 2018 | Pubmed ID: 30087119
Nonmuscle myosin-2 isoforms.
Current biology : CB Apr, 2019 | Pubmed ID: 31014482
Remarkable Rigidity of the Single α-Helical Domain of Myosin-VI As Revealed by NMR Spectroscopy.
Journal of the American Chemical Society Jun, 2019 | Pubmed ID: 31117653
Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution.
Toxins Jul, 2019 | Pubmed ID: 31319618
Competition between kinesin-1 and myosin-V defines posterior determination.
eLife Feb, 2020 | Pubmed ID: 32057294
Megakaryocyte migration defects due to nonmuscle myosin IIA mutations underlie thrombocytopenia in MYH9-related disease.
Blood 05, 2020 | Pubmed ID: 32315395
How Myosin 5 Walks Deduced from Single-Molecule Biophysical Approaches.
Advances in experimental medicine and biology , 2020 | Pubmed ID: 32451859
Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells.
Current biology : CB Jul, 2020 | Pubmed ID: 32502416
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
The Journal of biological chemistry Dec, 2020 | Pubmed ID: 33372036
The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 human deafness.
The Journal of biological chemistry Jan, 2021 | Pubmed ID: 33428946
A binding protein regulates myosin-7a dimerization and actin bundle assembly.
Nature communications 01, 2021 | Pubmed ID: 33495456