Department of Respiratory Medicine and Clinical Immunology
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Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2.
Genes & development Feb, 2004 | Pubmed ID: 14977921
Induction of cyclooxygenase-2 in reactive glial cells by the CD40 pathway: relevance to amyotrophic lateral sclerosis.
Journal of neurochemistry Oct, 2004 | Pubmed ID: 15447673
Guidance of myocardial patterning in cardiac development by Sema6D reverse signalling.
Nature cell biology Dec, 2004 | Pubmed ID: 15543137
Loss of dopaminergic neurons by the induction of inducible nitric oxide synthase and cyclooxygenase-2 via CD 40: relevance to Parkinson's disease.
Journal of neuroscience research Sep, 2005 | Pubmed ID: 16041799
FARP2 triggers signals for Sema3A-mediated axonal repulsion.
Nature neuroscience Dec, 2005 | Pubmed ID: 16286926
Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1.
The EMBO journal Mar, 2007 | Pubmed ID: 17318185
Edaravone, a free radical scavenger, ameliorates experimental autoimmune encephalomyelitis.
Neuroscience letters Aug, 2008 | Pubmed ID: 18579300
Involvement of Sema4A in the progression of experimental autoimmune myocarditis.
FEBS letters Nov, 2008 | Pubmed ID: 18977352
Astrocytic necrosis is induced by anti-aquaporin-4 antibody-positive serum.
Neuroreport Mar, 2009 | Pubmed ID: 19297740
Neuromyelitis optica: Passive transfer to rats by human immunoglobulin.
Biochemical and biophysical research communications Sep, 2009 | Pubmed ID: 19545538
Roles of Sema4D-plexin-B1 interactions in the central nervous system for pathogenesis of experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950) Feb, 2010 | Pubmed ID: 20038643
Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells.
Biochemical and biophysical research communications Mar, 2010 | Pubmed ID: 20188706
Semaphorins guide the entry of dendritic cells into the lymphatics by activating myosin II.
Nature immunology Jul, 2010 | Pubmed ID: 20512151
The role of immune semaphorins in multiple sclerosis.
FEBS letters Dec, 2011 | Pubmed ID: 21420960
A case of Behçet's disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Modern rheumatology Apr, 2012 | Pubmed ID: 21748365
Psoriatic arthritis in two patients with an inadequate response to treatment with tocilizumab.
Joint, bone, spine : revue du rhumatisme Jan, 2012 | Pubmed ID: 21962389
Early [18F]fluorodeoxyglucose positron emission tomography at two days of gefitinib treatment predicts clinical outcome in patients with adenocarcinoma of the lung.
Clinical cancer research : an official journal of the American Association for Cancer Research Jan, 2012 | Pubmed ID: 22019513
The lactic acid bacterium Pediococcus acidilactici suppresses autoimmune encephalomyelitis by inducing IL-10-producing regulatory T cells.
PloS one , 2011 | Pubmed ID: 22110705
Biased usage of T cell receptor β-chain variable region genes of Wilms' tumor gene (WT1)-specific CD8+ T cells in patients with solid tumors and healthy donors.
Cancer science Mar, 2012 | Pubmed ID: 22126448
HER2 as therapeutic target for overcoming ATP-binding cassette transporter-mediated chemoresistance in small cell lung cancer.
Molecular cancer therapeutics Apr, 2012 | Pubmed ID: 22389470
Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.
Genes & development Apr, 2012 | Pubmed ID: 22465952
Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-β therapy in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950) May, 2012 | Pubmed ID: 22491253
Tetraspanin CD151 protects against pulmonary fibrosis by maintaining epithelial integrity.
American journal of respiratory and critical care medicine Jul, 2012 | Pubmed ID: 22592804
Inhibitory roles of signal transducer and activator of transcription 3 in antitumor immunity during carcinogen-induced lung tumorigenesis.
Cancer research Jun, 2012 | Pubmed ID: 22659452
Suppression of metastases of small cell lung cancer cells in mice by a peptidic CXCR4 inhibitor TF14016.
FEBS letters Oct, 2012 | Pubmed ID: 22992418
Adiponectin: a novel link between adipocytes and COPD.
Vitamins and hormones , 2012 | Pubmed ID: 23017725
Semaphorins in bone development, homeostasis, and disease.
Seminars in cell & developmental biology Mar, 2013 | Pubmed ID: 23022498
Pathological role of interleukin-6 in psoriatic arthritis.
Arthritis , 2012 | Pubmed ID: 23133751
Deletion of tetraspanin CD9 diminishes lymphangiogenesis in vivo and in vitro.
The Journal of biological chemistry Jan, 2013 | Pubmed ID: 23223239
Recognition of a natural WT1 epitope by a modified WT1 peptide-specific T-cell receptor.
Anticancer research Dec, 2012 | Pubmed ID: 23225417
Functional human Th17 clones with WT1-specific helper activity.
Cancer immunology, immunotherapy : CII Apr, 2013 | Pubmed ID: 23275045
Echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) rearrangement in congenital pulmonary airway malformation.
Clinical lung cancer Jul, 2013 | Pubmed ID: 23357247
A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration.
Nature communications , 2013 | Pubmed ID: 23360997
HLA-DPB1*05: 01-restricted WT1332-specific TCR-transduced CD4+ T lymphocytes display a helper activity for WT1-specific CTL induction and a cytotoxicity against leukemia cells.
Journal of immunotherapy (Hagerstown, Md. : 1997) Apr, 2013 | Pubmed ID: 23502763
Drug-induced thrombotic thrombocytopenic purpura successfully treated with recombinant human soluble thrombomodulin.
Internal medicine (Tokyo, Japan) , 2013 | Pubmed ID: 23676600
Calretinin mediates apoptosis in small cell lung cancer cells expressing tetraspanin CD9.
FEBS open bio , 2013 | Pubmed ID: 23772398
Interleukin-16 promotes cardiac fibrosis and myocardial stiffening in heart failure with preserved ejection fraction.
PloS one , 2013 | Pubmed ID: 23894370
Molecular mechanism underlying the antiproliferative effect of suppressor of cytokine signaling-1 in non-small-cell lung cancer cells.
Cancer science Nov, 2013 | Pubmed ID: 23962256
Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.
Scientific reports , 2013 | Pubmed ID: 24036898
Statins decrease lung inflammation in mice by upregulating tetraspanin CD9 in macrophages.
PloS one , 2013 | Pubmed ID: 24040034
DNA damage in rheumatoid arthritis: an age-dependent increase in the lipid peroxidation-derived DNA adduct, heptanone-etheno-2'-deoxycytidine.
Autoimmune diseases , 2013 | Pubmed ID: 24222845
Tocilizumab for the treatment of patients with refractory Takayasu arteritis.
International heart journal , 2013 | Pubmed ID: 24309452
Sema4A inhibits the therapeutic effect of IFN-β in EAE.
Journal of neuroimmunology Mar, 2014 | Pubmed ID: 24439904
Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab.
Modern rheumatology Jan, 2015 | Pubmed ID: 24533556
Efficacy and safety of pirfenidone for idiopathic pulmonary fibrosis.
Patient preference and adherence , 2014 | Pubmed ID: 24711695
Comprehensive exploration of autoantibody in Behçet's disease: a novel autoantibody to claudin-1, an essential protein for tight junctions, is identified.
Joint, bone, spine : revue du rhumatisme Dec, 2014 | Pubmed ID: 24792642
CD16+CD56+ cells are a potential culprit for hematuria in IgA nephropathy.
Clinical and experimental nephrology Apr, 2015 | Pubmed ID: 24798970
A retrospective study of prognostic factors in patients with interstitial pneumonia receiving long-term oxygen therapy.
Lung Oct, 2014 | Pubmed ID: 25056241
Vaccination strategies to improve outcome of hematopoietic stem cell transplant in leukemia patients: early evidence and future prospects.
Expert review of hematology Oct, 2014 | Pubmed ID: 25186852
Germline variants in the SEMA4A gene predispose to familial colorectal cancer type X.
Nature communications Oct, 2014 | Pubmed ID: 25307848
Development of microscopic polyangiitis-related pulmonary fibrosis in a patient with autoimmune pulmonary alveolar proteinosis.
BMC pulmonary medicine Nov, 2014 | Pubmed ID: 25366193
Favorable response to trastuzumab plus irinotecan combination therapy in two patients with HER2-positive relapsed small-cell lung cancer.
Lung cancer (Amsterdam, Netherlands) Mar, 2015 | Pubmed ID: 25601188
Semaphorin 4D Contributes to Rheumatoid Arthritis by Inducing Inflammatory Cytokine Production: Pathogenic and Therapeutic Implications.
Arthritis & rheumatology (Hoboken, N.J.) Jun, 2015 | Pubmed ID: 25707877
Dapsone hypersensitivity syndrome-related lung injury without eosinophilia in the bronchoalveolar lavage fluid.
Internal medicine (Tokyo, Japan) , 2015 | Pubmed ID: 25832951
Interleukin-6/interleukin-21 signaling axis is critical in the pathogenesis of pulmonary arterial hypertension.
Proceedings of the National Academy of Sciences of the United States of America May, 2015 | Pubmed ID: 25941359
Leucine-Rich Repeat Kinase 1 Regulates Autophagy through Turning On TBC1D2-Dependent Rab7 Inactivation.
Molecular and cellular biology Sep, 2015 | Pubmed ID: 26100023
mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.
Journal of immunology (Baltimore, Md. : 1950) Aug, 2015 | Pubmed ID: 26116513
An Immunocompetent Mouse Model for MLL/AF9 Leukemia Reveals the Potential of Spontaneous Cytotoxic T-Cell Response to an Antigen Expressed in Leukemia Cells.
PloS one , 2015 | Pubmed ID: 26658107
Glycosylation Status of CD43 Protein Is Associated with Resistance of Leukemia Cells to CTL-Mediated Cytolysis.
PloS one , 2016 | Pubmed ID: 27011118
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.
Nature communications Apr, 2016 | Pubmed ID: 27046227
The Proportion of Regulatory T Cells in Patients with Rheumatoid Arthritis: A Meta-Analysis.
PloS one , 2016 | Pubmed ID: 27622457
Clarifying the biological significance of the CHK2 K373E somatic mutation discovered in The Cancer Genome Atlas database.
FEBS letters Dec, 2016 | Pubmed ID: 27716909
The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems.
Cell adhesion & migration 11, 2016 | Pubmed ID: 27736304
Characterizing Semaphorin-Mediated Immune Responses Using an Antigen-Presentation Assay.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27787865
Syndecan-4 as a biomarker to predict clinical outcome for glioblastoma multiforme treated with WT1 peptide vaccine.
Future science OA Dec, 2016 | Pubmed ID: 28116121
Rapid intracranial response to osimertinib, without radiotherapy, in nonsmall cell lung cancer patients harboring the EGFR T790M mutation: Two Case Reports.
Medicine Feb, 2017 | Pubmed ID: 28178168
Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody.
Scientific reports 02, 2017 | Pubmed ID: 28230086
Mouse model of Epstein-Barr virus LMP1- and LMP2A-driven germinal center B-cell lymphoproliferative disease.
Proceedings of the National Academy of Sciences of the United States of America 05, 2017 | Pubmed ID: 28351978
Semaphorin 4D inhibits neutrophil activation and is involved in the pathogenesis of neutrophil-mediated autoimmune vasculitis.
Annals of the rheumatic diseases Aug, 2017 | Pubmed ID: 28416516
Interleukin-17A Promotes Lung Tumor Progression through Neutrophil Attraction to Tumor Sites and Mediating Resistance to PD-1 Blockade.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 08, 2017 | Pubmed ID: 28483607
Trastuzumab emtansine suppresses the growth of HER2-positive small-cell lung cancer in preclinical models.
Biochemical and biophysical research communications 07, 2017 | Pubmed ID: 28526406
Wilms tumour 1 peptide vaccine as a cure-oriented post-chemotherapy strategy for patients with acute myeloid leukaemia at high risk of relapse.
British journal of haematology 07, 2018 | Pubmed ID: 28542830
Carboplatin plus weekly nanoparticle albumin-bound paclitaxel in elderly patients with previously untreated advanced squamous non-small-cell lung cancer selected based on Mini Nutritional Assessment short-form scores: a multicenter phase 2 study.
Cancer chemotherapy and pharmacology Sep, 2017 | Pubmed ID: 28688052
Lamtor1 Is Critically Required for CD4 T Cell Proliferation and Regulatory T Cell Suppressive Function.
Journal of immunology (Baltimore, Md. : 1950) 09, 2017 | Pubmed ID: 28768723
Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.
Proceedings of the National Academy of Sciences of the United States of America 09, 2017 | Pubmed ID: 28878025
Minimal neonatal transfer of certolizumab pegol in a Japanese patient with rheumatoid arthritis.
Annals of the rheumatic diseases 09, 2018 | Pubmed ID: 28939633
Wilms' Tumor Gene 1 (WT1) Peptide Vaccine Therapy for Hematological Malignancies: From CTL Epitope Identification to Recent Progress in Clinical Studies Including a Cure-Oriented Strategy.
Oncology research and treatment , 2017 | Pubmed ID: 29041012
The activated conformation of integrin β is a novel multiple myeloma-specific target for CAR T cell therapy.
Nature medicine Dec, 2017 | Pubmed ID: 29106400
Febuxostat ameliorates secondary progressive experimental autoimmune encephalomyelitis by restoring mitochondrial energy production in a GOT2-dependent manner.
PloS one , 2017 | Pubmed ID: 29107957
Quantitative pulmonary blood flow measurement using O-HO PET with and without tissue fraction correction: a comparison study.
EJNMMI research Dec, 2017 | Pubmed ID: 29274016
Clinical response to PD-1 blockade correlates with a sub-fraction of peripheral central memory CD4+ T cells in patients with malignant melanoma.
International immunology 02, 2018 | Pubmed ID: 29294043
WT1 peptide-based immunotherapy for advanced thymic epithelial malignancies.
International journal of cancer 06, 2018 | Pubmed ID: 29322496
Combination Gemcitabine and WT1 Peptide Vaccination Improves Progression-Free Survival in Advanced Pancreatic Ductal Adenocarcinoma: A Phase II Randomized Study.
Cancer immunology research Jan, 2018 | Pubmed ID: 29358173
Beneficial effects of fingolimod in MS patients with high serum Sema4A levels.
PloS one , 2018 | Pubmed ID: 29518148
Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging.
Scientific reports 03, 2018 | Pubmed ID: 29572511
Lysosomal Protein Lamtor1 Controls Innate Immune Responses via Nuclear Translocation of Transcription Factor EB.
Journal of immunology (Baltimore, Md. : 1950) 06, 2018 | Pubmed ID: 29686050
Cerebrospinal fluid mitochondrial DNA in neuromyelitis optica spectrum disorder.
Journal of neuroinflammation Apr, 2018 | Pubmed ID: 29703264
Semaphorin 6D reverse signaling controls macrophage lipid metabolism and anti-inflammatory polarization.
Nature immunology 06, 2018 | Pubmed ID: 29777213
The Direct Oblique Method: A New Gold Standard for Bronchoscopic Navigation That is Superior to Automatic Methods.
Journal of bronchology & interventional pulmonology Oct, 2018 | Pubmed ID: 29901530
Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity.
International immunology 02, 2019 | Pubmed ID: 30239772
Long-term outcomes of advanced thymoma in patients undergoing preoperative chemotherapy or chemoradiotherapy followed by surgery: a 20-year experience.
Interactive cardiovascular and thoracic surgery 03, 2019 | Pubmed ID: 30256943
Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients.
JCI insight 10, 2018 | Pubmed ID: 30282824
SEMA4A promotes eosinophil survival and contributes to eosinophil-mediated allergic diseases.
Allergology international : official journal of the Japanese Society of Allergology Apr, 2019 | Pubmed ID: 30342889
Integration of genetics and miRNA-target gene network identified disease biology implicated in tissue specificity.
Nucleic acids research 12, 2018 | Pubmed ID: 30407537
Extremely strong infiltration of WT1-specific CTLs into mouse tumor by the combination vaccine with WT1-specific CTL and helper peptides.
Oncotarget Nov, 2018 | Pubmed ID: 30542516
Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells.
JCI insight 12, 2018 | Pubmed ID: 30568033
Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer.
Oncotarget Dec, 2018 | Pubmed ID: 30680067
Anti-receptor activator of nuclear factor κB ligand antibody treatment increases osteoclastogenesis-promoting IL-8 in patients with rheumatoid arthritis.
International immunology 04, 2019 | Pubmed ID: 30753461
Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study.
Arthritis research & therapy 04, 2019 | Pubmed ID: 30971306
Unique Case of Pseudoprogression Manifesting as Lung Cavitation After Pembrolizumab Treatment.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 05, 2019 | Pubmed ID: 31027746
Correction to: Drug tolerability and reasons for discontinuation of seven biologics in 4466 treatment courses of rheumatoid arthritis-the ANSWER cohort study.
Arthritis research & therapy May, 2019 | Pubmed ID: 31060597
Response to: 'Blood plasma versus serum: which is right for sampling circulating membrane microvesicles in human subjects?' by Liu .
Annals of the rheumatic diseases May, 2019 | Pubmed ID: 31097418
A lung abscess caused by secondary syphilis - the utility of polymerase chain reaction techniques in transbronchial biopsy: a case report.
BMC infectious diseases Jul, 2019 | Pubmed ID: 31288744
The therapeutic efficacy of intravenous immunoglobulin in anti-neutrophilic cytoplasmic antibody-associated vasculitis: a meta-analysis.
Rheumatology (Oxford, England) Aug, 2019 | Pubmed ID: 31377800
Immune adjuvant therapy using Bacillus Calmette-Guérin cell wall skeleton (BCG-CWS) in advanced malignancies: A phase 1 study of safety and immunogenicity assessments.
Medicine Aug, 2019 | Pubmed ID: 31415377
The Outcomes of Induction Chemoradiotherapy Followed by Surgery for Clinical T3-4 Non-Small Cell Lung Cancer.
Technology in cancer research & treatment 01, 2019 | Pubmed ID: 31455166
Monitoring antibody binding to T cells in a pembrolizumab-treated patient with lung adenocarcinoma on hemodialysis.
Thoracic cancer Nov, 2019 | Pubmed ID: 31520515
Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population.
Annals of the rheumatic diseases Jan, 2020 | Pubmed ID: 31699813
Severe myocarditis with slight lymphocytic infiltration after nivolumab treatment.
Lung cancer (Amsterdam, Netherlands) Feb, 2020 | Pubmed ID: 31848027