Simon Messing trained as structural biologist with Dr. Mario Amzel at Johns Hopkins School of Medicine, where he received a Ph.D. while investigating Nudix hydrolases and plant dioxygenases. As a post-doctoral fellow at NIH with Dr. Frederick Dyda he studied transposition, and worked on several transposases, ultimately solving the structure of a new class of transposases TnpA(REP). Simon is now at Frederick National Labs, and is a part of the RAS Initiative, helping to find novel drug targets of RAS and its associated proteins.