Basal Ganglia Pathophysiology Unit,
Dept. Experimental Medical Science,
Basal Ganglia Pathophysiology Unit, Dept. Experimental Medical Science
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cAMP response element-binding protein is required for dopamine-dependent gene expression in the intact but not the dopamine-denervated striatum.
The Journal of neuroscience : the official journal of the Society for Neuroscience Dec, 2001 | Pubmed ID: 11739600
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.
The European journal of neuroscience Jan, 2002 | Pubmed ID: 11860512
L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function.
Neurobiology of disease Jul, 2002 | Pubmed ID: 12127155
Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
Neurobiology of disease Mar, 2006 | Pubmed ID: 16256359
Dyskinesias and dopamine cell replacement in Parkinson's disease: a clinical perspective.
Brain research bulletin Dec, 2005 | Pubmed ID: 16324999
Post- versus presynaptic plasticity in L-DOPA-induced dyskinesia.
Journal of neurochemistry Oct, 2006 | Pubmed ID: 16942598
Endothelial proliferation and increased blood-brain barrier permeability in the basal ganglia in a rat model of 3,4-dihydroxyphenyl-L-alanine-induced dyskinesia.
The Journal of neuroscience : the official journal of the Society for Neuroscience Sep, 2006 | Pubmed ID: 16971529
The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration.
Behavioural brain research Feb, 2007 | Pubmed ID: 17157933
Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease.
Journal of neurochemistry Apr, 2007 | Pubmed ID: 17359492
Dopamine dysregulation of movement control in L-DOPA-induced dyskinesia.
Trends in neurosciences May, 2007 | Pubmed ID: 17400300
Spatiotemporal pattern of striatal ERK1/2 phosphorylation in a rat model of L-DOPA-induced dyskinesia and the role of dopamine D1 receptors.
Biological psychiatry Oct, 2007 | Pubmed ID: 17662258
L-DOPA-induced dyskinesia: cellular mechanisms and approaches to treatment.
Parkinsonism & related disorders , 2007 | Pubmed ID: 18267248
Ratings of L-DOPA-induced dyskinesia in the unilateral 6-OHDA lesion model of Parkinson's disease in rats and mice.
Current protocols in neuroscience Oct, 2007 | Pubmed ID: 18428668
Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling.
The Journal of pharmacology and experimental therapeutics Jul, 2009 | Pubmed ID: 19357321
Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Nov, 2009 | Pubmed ID: 19606087
L-DOPA-induced dopamine efflux in the striatum and the substantia nigra in a rat model of Parkinson's disease: temporal and quantitative relationship to the expression of dyskinesia.
Journal of neurochemistry Mar, 2010 | Pubmed ID: 20050978
Plastic effects of L-DOPA treatment in the basal ganglia and their relevance to the development of dyskinesia.
Parkinsonism & related disorders Dec, 2009 | Pubmed ID: 20083009
Rodent models of treatment-induced motor complications in Parkinson's disease.
Parkinsonism & related disorders Dec, 2009 | Pubmed ID: 20123549
A mGluR5 antagonist under clinical development improves L-DOPA-induced dyskinesia in parkinsonian rats and monkeys.
Neurobiology of disease Sep, 2010 | Pubmed ID: 20452425
Maladaptive striatal plasticity in L-DOPA-induced dyskinesia.
Progress in brain research , 2010 | Pubmed ID: 20696322
Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia.
Annals of neurology Nov, 2010 | Pubmed ID: 20882603
Inhibition of Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) signaling in the striatum reverts motor symptoms associated with L-dopa-induced dyskinesia.
Proceedings of the National Academy of Sciences of the United States of America Dec, 2010 | Pubmed ID: 21115823
Impact of the lesion procedure on the profiles of motor impairment and molecular responsiveness to L-DOPA in the 6-hydroxydopamine mouse model of Parkinson's disease.
Neurobiology of disease Jun, 2011 | Pubmed ID: 21310234
Vascular endothelial growth factor is upregulated by L-dopa in the parkinsonian brain: implications for the development of dyskinesia.
Brain : a journal of neurology Aug, 2011 | Pubmed ID: 21771855
Current options and future possibilities for the treatment of dyskinesia and motor fluctuations in Parkinson's disease.
CNS & neurological disorders drug targets Sep, 2011 | Pubmed ID: 21838677
Impact of L-DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease.
NeuroImage May, 2012 | Pubmed ID: 22406356
Levodopa-induced dyskinesia is strongly associated with resonant cortical oscillations.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2012 | Pubmed ID: 23175810
A model of GDNF gene therapy in mice with 6-Hydroxydopamine lesions: time course of Neurorestorative effects and ERK1/2 activation.
Journal of Parkinson's disease , 2012 | Pubmed ID: 23938263
Bad news for neuroprotective therapies in PD?
Journal of Parkinson's disease Jan, 2013 | Pubmed ID: 24018335
Modulating mGluR5 and 5-HT1A/1B receptors to treat l-DOPA-induced dyskinesia: effects of combined treatment and possible mechanisms of action.
Experimental neurology Dec, 2013 | Pubmed ID: 24029003
Region-specific restoration of striatal synaptic plasticity by dopamine grafts in experimental parkinsonism.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2013 | Pubmed ID: 24170862
Investigating the molecular mechanisms of L-DOPA-induced dyskinesia in the mouse.
Parkinsonism & related disorders Jan, 2014 | Pubmed ID: 24262181
Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2014 | Pubmed ID: 24599591
Glutamatergic pathways as a target for the treatment of dyskinesias in Parkinson's disease.
Biochemical Society transactions Apr, 2014 | Pubmed ID: 24646284
Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5.
The Journal of neuroscience : the official journal of the Society for Neuroscience Mar, 2014 | Pubmed ID: 24672017
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.
Brain : a journal of neurology Jul, 2014 | Pubmed ID: 24755275
A Genetic Mouse Model of Parkinson's Disease Shows Involuntary Movements and Increased Postsynaptic Sensitivity to Apomorphine.
Molecular neurobiology Dec, 2015 | Pubmed ID: 25307288
Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia.
Nature communications Oct, 2014 | Pubmed ID: 25360704
Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications.
Frontiers in neurology , 2014 | Pubmed ID: 25566170
Activity of serotonin 5-HT(1A) receptor 'biased agonists' in rat models of Parkinson's disease and L-DOPA-induced dyskinesia.
Neuropharmacology Jun, 2015 | Pubmed ID: 25645393
Pharmacological stimulation of metabotropic glutamate receptor type 4 in a rat model of Parkinson's disease and L-DOPA-induced dyskinesia: Comparison between a positive allosteric modulator and an orthosteric agonist.
Neuropharmacology Aug, 2015 | Pubmed ID: 25749357
Zooming in on the small: the plasticity of striatal dendritic spines in L-DOPA-induced dyskinesia.
Movement disorders : official journal of the Movement Disorder Society Apr, 2015 | Pubmed ID: 25759263
Rodent models of impulsive-compulsive behaviors in Parkinson's disease: How far have we reached?
Neurobiology of disease Oct, 2015 | Pubmed ID: 26325219
Increased CSF biomarkers of angiogenesis in Parkinson disease.
Neurology Nov, 2015 | Pubmed ID: 26511451
M4 Muscarinic Receptor Signaling Ameliorates Striatal Plasticity Deficits in Models of L-DOPA-Induced Dyskinesia.
Neuron Nov, 2015 | Pubmed ID: 26590347
On the Effect of Eltoprazine in Dyskinetic Hemiparkinsonian Rats.
Movement disorders : official journal of the Movement Disorder Society Jan, 2016 | Pubmed ID: 26749366
Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26787858
Dramatic differences in susceptibility to l-DOPA-induced dyskinesia between mice that are aged before or after a nigrostriatal dopamine lesion.
Neurobiology of disease Oct, 2016 | Pubmed ID: 27312773
Dissociation of metabolic and hemodynamic levodopa responses in the 6-hydroxydopamine rat model.
Neurobiology of disease Dec, 2016 | Pubmed ID: 27544483
Validation of an improved scale for rating l-DOPA-induced dyskinesia in the mouse and effects of specific dopamine receptor antagonists.
Neurobiology of disease Dec, 2016 | Pubmed ID: 27597526
Differential effects of gaseous versus injectable anesthetics on changes in regional cerebral blood flow and metabolism induced by l-DOPA in a rat model of Parkinson's disease.
Experimental neurology 06, 2017 | Pubmed ID: 28284817
Neuroprotection and neurorestoration as experimental therapeutics for Parkinson's disease.
Experimental neurology 12, 2017 | Pubmed ID: 28988910
CK2 Oppositely Modulates l-DOPA-Induced Dyskinesia via Striatal Projection Neurons Expressing D1 or D2 Receptors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 12, 2017 | Pubmed ID: 29097596
Translating scientific advances into disease-modifying therapies for Parkinson's Disease.
Experimental neurology 12, 2017 | Pubmed ID: 29145992
Levodopa-induced abnormal involuntary movements correlate with altered permeability of the blood-brain-barrier in the basal ganglia.
Scientific reports 11, 2017 | Pubmed ID: 29167476
Animal models of l-dopa-induced dyskinesia in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society 07, 2018 | Pubmed ID: 29488257
mGlu receptors in the treatment of Parkinson's disease and L-DOPA-induced dyskinesia.
Current opinion in pharmacology 02, 2018 | Pubmed ID: 29625424
On the neuronal circuitry mediating L-DOPA-induced dyskinesia.
Journal of neural transmission (Vienna, Austria : 1996) 08, 2018 | Pubmed ID: 29704061
Striatonigral neurons divide into two distinct morphological-physiological phenotypes after chronic L-DOPA treatment in parkinsonian rats.
Scientific reports 07, 2018 | Pubmed ID: 29968767
Significance and Translational Value of High-Frequency Cortico-Basal Ganglia Oscillations in Parkinson's Disease.
Journal of Parkinson's disease , 2019 | Pubmed ID: 30594935
Pridopidine Induces Functional Neurorestoration Via the Sigma-1 Receptor in a Mouse Model of Parkinson's Disease.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 04, 2019 | Pubmed ID: 30756361
Seeding of protein aggregation causes cognitive impairment in rat model of cortical synucleinopathy.
Movement disorders : official journal of the Movement Disorder Society 11, 2019 | Pubmed ID: 31449702
Dyskinesia matters.
Movement disorders : official journal of the Movement Disorder Society Mar, 2020 | Pubmed ID: 31872501
D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson's disease.
The Journal of clinical investigation Mar, 2020 | Pubmed ID: 32039920
The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications.
Progress in brain research , 2020 | Pubmed ID: 32247363
Animal models for preclinical Parkinson's research: An update and critical appraisal.
Progress in brain research , 2020 | Pubmed ID: 32247366
Preface: The evolving scenario of Parkinson's research.
Progress in brain research , 2020 | Pubmed ID: 32247377
Reply to: Letter to Editor by Chaudhuri, Jenner, Antonini.
Movement disorders : official journal of the Movement Disorder Society May, 2020 | Pubmed ID: 32415716