Division of Human Biology,
Clinical Research,
Public Health Sciences
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Development of human protein reference database as an initial platform for approaching systems biology in humans.
Genome research Oct, 2003 | Pubmed ID: 14525934
RNAi on the apoptosis TRAIL: the mammalian cell genetic screen comes of age.
Developmental cell Oct, 2003 | Pubmed ID: 14536054
A map of the interactome network of the metazoan C. elegans.
Science (New York, N.Y.) Jan, 2004 | Pubmed ID: 14704431
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network.
Molecular cell Feb, 2004 | Pubmed ID: 14992718
Functional genomic analysis of RNA interference in C. elegans.
Science (New York, N.Y.) May, 2005 | Pubmed ID: 15790806
The limits of reductionism in medicine: could systems biology offer an alternative?
PLoS medicine May, 2006 | Pubmed ID: 16681415
The clinical applications of a systems approach.
PLoS medicine Jul, 2006 | Pubmed ID: 16683861
The 14-3-3 protein FTT-2 regulates DAF-16 in Caenorhabditis elegans.
Developmental biology Jan, 2007 | Pubmed ID: 17098225
Network modeling links breast cancer susceptibility and centrosome dysfunction.
Nature genetics Nov, 2007 | Pubmed ID: 17922014
Derivation, characterization, and in vitro differentiation of canine embryonic stem cells.
Stem cells (Dayton, Ohio) Feb, 2008 | Pubmed ID: 18065395
MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries.
Stem cells (Dayton, Ohio) Oct, 2008 | Pubmed ID: 18583537
Circulating microRNAs as stable blood-based markers for cancer detection.
Proceedings of the National Academy of Sciences of the United States of America Jul, 2008 | Pubmed ID: 18663219
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
Nature methods Jan, 2009 | Pubmed ID: 19123269
Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.
Cell stem cell Apr, 2009 | Pubmed ID: 19341625
Repertoire of microRNAs in epithelial ovarian cancer as determined by next generation sequencing of small RNA cDNA libraries.
PloS one , 2009 | Pubmed ID: 19390579
Multiple integrated copies and high-level production of the human retrovirus XMRV (xenotropic murine leukemia virus-related virus) from 22Rv1 prostate carcinoma cells.
Journal of virology Jul, 2009 | Pubmed ID: 19403664
Evaluation of the 8q24 prostate cancer risk locus and MYC expression.
Cancer research Jul, 2009 | Pubmed ID: 19549893
Limitations and possibilities of small RNA digital gene expression profiling.
Nature methods Jul, 2009 | Pubmed ID: 19564845
Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: evidence supporting a mesothelial-to-epithelial transition.
Gynecologic oncology Jan, 2010 | Pubmed ID: 19854497
Analysis of circulating microRNA biomarkers in plasma and serum using quantitative reverse transcription-PCR (qRT-PCR).
Methods (San Diego, Calif.) Apr, 2010 | Pubmed ID: 20146939
MiR-221 and MiR-222 alterations in sporadic ovarian carcinoma: Relationship to CDKN1B, CDKNIC and overall survival.
Genes, chromosomes & cancer Jul, 2010 | Pubmed ID: 20461750
The next thing in prognostic molecular markers: microRNA signatures of cancer.
Gut Jun, 2010 | Pubmed ID: 20551450
Activation of the MEK-S6 pathway in high-grade ovarian cancers.
Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry Dec, 2010 | Pubmed ID: 20661131
Nanostructure-enhanced laser tweezers for efficient trapping and alignment of particles.
Optics express Jul, 2010 | Pubmed ID: 20720985
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2011 | Pubmed ID: 21383194
MicroRNA-138 modulates DNA damage response by repressing histone H2AX expression.
Molecular cancer research : MCR Aug, 2011 | Pubmed ID: 21693595
Metastatic progression of prostate cancer and e-cadherin regulation by zeb1 and SRC family kinases.
The American journal of pathology Jul, 2011 | Pubmed ID: 21703419
HIF induces human embryonic stem cell markers in cancer cells.
Cancer research Jul, 2011 | Pubmed ID: 21712410
Post-transcriptional generation of miRNA variants by multiple nucleotidyl transferases contributes to miRNA transcriptome complexity.
Genome research Sep, 2011 | Pubmed ID: 21813625
An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription.
Nucleic acids research Jan, 2012 | Pubmed ID: 21917857
Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies.
Cancer prevention research (Philadelphia, Pa.) Dec, 2011 | Pubmed ID: 22158052
1Electrical Engineering Department, University of Washington,
2Division of Human Biology, Fred Hutchinson Cancer Research Center ,
3Molecular and Cellular Biology Program, University of Washington,
4Clinical Research, Fred Hutchinson Cancer Research Center ,
5Public Health Sciences, Fred Hutchinson Cancer Research Center