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Leicester Cancer Research Center
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Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes.
The EMBO journal Mar, 2001 | Pubmed ID: 11230124
Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein.
The Journal of biological chemistry Mar, 2002 | Pubmed ID: 11801595
Caspase activation inhibits proteasome function during apoptosis.
Molecular cell Apr, 2004 | Pubmed ID: 15068805
Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase.
Molecular biology of the cell Apr, 2007 | Pubmed ID: 17287400
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia.
Blood Apr, 2009 | Pubmed ID: 19008458
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing.
The Journal of biological chemistry May, 2009 | Pubmed ID: 19258326
Reconstitution of the death-inducing signaling complex reveals a substrate switch that determines CD95-mediated death or survival.
Molecular cell Aug, 2009 | Pubmed ID: 19683492
The fate of benzene-oxide.
Chemico-biological interactions Mar, 2010 | Pubmed ID: 20036650
Role of NOXA and its ubiquitination in proteasome inhibitor-induced apoptosis in chronic lymphocytic leukemia cells.
Haematologica Sep, 2010 | Pubmed ID: 20378569
Sabutoclax (BI97C1) and BI112D1, putative inhibitors of MCL-1, induce mitochondrial fragmentation either upstream of or independent of apoptosis.
Neoplasia (New York, N.Y.) May, 2013 | Pubmed ID: 23633928
University of Leicester
Giuditta Viticchié1,
Ian Powley1,
Constantinos Demetriou1,
James Cooper1,
Michael Butterworth1,
Meeta Patel1,
Naila Abid1,
Gareth Miles1,
Lynne Howells1,
Howard Pringle1,
Marion MacFarlane2,
Catrin Pritchard1
1Leicester Cancer Research Center, University of Leicester,
2, MRC Toxicology Unit
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