John P. Cooke

Executive Summary: Pivotal Research in Cardiovascular Syndromes in the Elderly.

Effect of local delivery of L-arginine on in-stent restenosis in humans.

Statins have biphasic effects on angiogenesis.

Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor.

Nitric oxide and angiogenesis.

Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice.

Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase.

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors.

Homocysteine impairs coronary microvascular dilator function in humans.

Does leptin cause vascular disease?

Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases.

Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis.

Flow, NO, and atherogenesis.

Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions.

Nicotine promotes arteriogenesis.

NOS inhibition accelerates atherogenesis: reversal by exercise.

Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway.

Flow-responsive remodeling after angioplasty is enhanced by high cholesterol diet. Prevention with pyrrolidine dithiocarbamate.

A peculiar result and a fanciful hypothesis regarding L-arginine.

Nitric oxide inhibition as a mechanism for blood pressure increase during salt loading in normotensive postmenopausal women.

Postgraduate training in vascular medicine: proposed requirements and standards.

Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial.

Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine.

A novel mechanism for pulmonary arterial hypertension?

Gender differences in perception of PAD: a pilot study.

Second hand smoke stimulates tumor angiogenesis and growth.

Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence.

Asymmetric dimethylarginine (ADMA): a key regulator of nitric oxide synthase.

NO and angiogenesis.

Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis.

Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis.

Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia.

Nicotine and angiogenesis: a new paradigm for tobacco-related diseases.

Asymmetrical dimethylarginine: the Uber marker?

Randomized trial of AT-1015 for treatment of intermittent claudication. A novel 5-hydroxytryptamine antagonist with no evidence of efficacy.

Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia.

Predictors of physical function in patients with peripherial arterial disease and claudication.

The pivotal role of nitric oxide for vascular health.

Adenoviral gene transfer with soluble vascular endothelial growth factor receptors impairs angiogenesis and perfusion in a murine model of hindlimb ischemia.

Determination of asymmetric dimethylarginine (ADMA) using a novel ELISA assay.

Exercise patterns and cardiovascular fitness of patients with peripheral arterial disease.

Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma.

Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis.

Suboptimal intensity of risk factor modification in PAD.

Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease.

Homocysteine-induced vascular dysregulation is mediated by the NMDA receptor.

Arginine metabolism, pulmonary hypertension, and sickle cell disease.

Abnormal cardiovascular response to exercise in patients with peripheral arterial disease: Implications for management.

A pilot study of L-arginine supplementation on functional capacity in peripheral arterial disease.

Vascular compliance versus flow-mediated vasodilation: correlation with cardiovascular risk factors.

Mechanisms of Raynaud's disease.

ADMA: an emerging cardiovascular risk factor.

ADMA: its role in vascular disease.

Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA.

Re: The American "board" of vascular medicine: questions and concerns.

Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis.

ADMA increases arterial stiffness and decreases cerebral blood flow in humans.

Psychophysiological and cortisol responses to psychological stress in depressed and nondepressed older men and women with elevated cardiovascular disease risk.

Letter by Kielstein et al regarding article, "Renal function as a predictor of outcome in a broad spectrum of patients with heart failure".

Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection.

T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease.

A central role for nicotinic cholinergic regulation of growth factor-induced endothelial cell migration.

Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia.

Endothelial progenitor cells participate in nicotine-mediated angiogenesis.

Should we measure asymmetric dimethylarginine in patients with coronary artery disease?

Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia.

Limb hemodynamics are not predictive of functional capacity in patients with PAD.

SVMB presidential address. The time has come for vascular medicine.

Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury.

Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor.

NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL.

[Coronary allograft vasculopathy: pathophysiological interaction between the immune system, infections and metabolic syndrome].

Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis.

Changes in coronary arterial dimensions early after cardiac transplantation.

Asymmetric dimethyl-arginine and coronary artery calcification in young adults entering middle age: the CARDIA Study.

A novel bioluminescent tumor model of human renal cancer cell lines: an in vitro and in vivo characterization.

Asymmetric dimethyl L-arginine (ADMA) is a critical regulator of myocardial reperfusion injury.

L-arginine supplementation in peripheral arterial disease: no benefit and possible harm.

Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology.

Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies.

Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease.

Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation.

Task force 11: training in vascular medicine and peripheral vascular catheter-based interventions endorsed by the Society for Cardiovascular Angiography and Interventions and the Society for Vascular Medicine.

Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity.

Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus.

Mecamylamine suppresses Basal and nicotine-stimulated choroidal neovascularization.

Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia.

Critical determinants of limb ischemia.

A biomarker panel for peripheral arterial disease.

Two cardiovascular risk factors in one? Homocysteine and its relation to glomerular filtration rate. A meta-analysis of 41 studies with 27,000 participants.

Letter by Stuehlinger et al regarding article, "Metabolic profiling of arginine and nitric oxide pathways predicts hemodynamic abnormalities and mortality in patients with cardiogenic shock after acute myocardial infarction".

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways.

Endothelial nicotinic acetylcholine receptors and angiogenesis.

Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?

Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor.

Hypercholesterolemia impairs exercise capacity in mice.

Extensive characterization of the human DDAH1 transgenic mice.

Cell-free production of transducible transcription factors for nuclear reprogramming.

nAChRs mediate human embryonic stem cell-derived endothelial cells: proliferation, apoptosis, and angiogenesis.

Chronic exposure to nicotine impairs cholinergic angiogenesis.

Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia.

Role of nitric oxide signaling in endothelial differentiation of embryonic stem cells.

Relationship of asymmetric dimethylarginine and homocysteine to vascular aging in systemic lupus erythematosus patients.

Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion.

Topical mecamylamine for diabetic macular edema.

DDAH: a target for vascular therapy?

Biomarkers of peripheral arterial disease.

Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease.

A matrix micropatterning platform for cell localization and stem cell fate determination.

Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells.

The emerging role of the thioredoxin system in angiogenesis.

Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?

Cerebral autoregulation in the vertebral and middle cerebral arteries during combine head upright tilt and lower body negative pressure in healthy humans.

Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization.

MicroRNA and mechanisms of impaired angiogenesis in diabetes mellitus.

The role of nicotine in the pathogenesis of atherosclerosis.

Dietary nitrate, nitric oxide, and restenosis.

Identification and classification of acute cardiac rejection by intragraft transcriptional profiling.

Low lifetime recreational activity is a risk factor for peripheral arterial disease.

DDAH says NO to ADMA.

Two decades of progress in vascular medicine.

Solubility partner IF2 Domain I enables high yield synthesis of transducible transcription factors in Escherichia coli.

Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance.

Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease.

Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.

Lymphangiogenesis: A Potential New Therapy for Lymphedema?