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A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo.
Molecular cancer therapeutics Aug, 2012 | Pubmed ID: 22689530
Orally efficacious novel small molecule 6-chloro-6-deoxy-1,2,3,4-tetra-O-galloyl-α-D-glucopyranose selectively and potently stimulates insulin receptor and alleviates diabetes.
Journal of molecular endocrinology , 2013 | Pubmed ID: 23549408
Constituents of an extract of Cryptocarya rubra housed in a repository with cytotoxic and glucose transport inhibitory effects.
Journal of natural products Mar, 2014 | Pubmed ID: 24344605
Biological and biomedical functions of Penta-O-galloyl-D-glucose and its derivatives.
Journal of natural medicines Jul, 2014 | Pubmed ID: 24532420
Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells.
Cancer letters Sep, 2014 | Pubmed ID: 24973521
The Warburg effect: evolving interpretations of an established concept.
Free radical biology & medicine Feb, 2015 | Pubmed ID: 25277420
Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells.
ChemMedChem Nov, 2015 | Pubmed ID: 26332543
Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice.
Endocrinology 05, 2016 | Pubmed ID: 27035649
Extracellular ATP a New Player in Cancer Metabolism: NSCLC Cells Internalize ATP In Vitro and In Vivo Using Multiple Endocytic Mechanisms.
Molecular cancer research : MCR 11, 2016 | Pubmed ID: 27578770
Growth Hormone and the Epithelial-to-Mesenchymal Transition.
The Journal of clinical endocrinology and metabolism 10, 2017 | Pubmed ID: 28938477
Extracellular ATP, as an energy and phosphorylating molecule, induces different types of drug resistances in cancer cells through ATP internalization and intracellular ATP level increase.
Oncotarget Oct, 2017 | Pubmed ID: 29152126
MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?
European journal of endocrinology May, 2018 | Pubmed ID: 29459441
Adipocyte-Specific GH Receptor-Null (AdGHRKO) Mice Have Enhanced Insulin Sensitivity With Reduced Liver Triglycerides.
Endocrinology 01, 2019 | Pubmed ID: 30462209
GH Knockout Mice Have Increased Subcutaneous Adipose Tissue With Decreased Fibrosis and Enhanced Insulin Sensitivity.
Endocrinology 07, 2019 | Pubmed ID: 31099824
Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma.
Cancers Sep, 2019 | Pubmed ID: 31547367
The Effects of 20-kDa Human Placental GH in Male and Female GH-deficient Mice: An Improved Human GH?
Endocrinology 08, 2020 | Pubmed ID: 32556100
Isosteres of ester derived glucose uptake inhibitors.
Bioorganic & medicinal chemistry letters 09, 2020 | Pubmed ID: 32736210
Mouse models of growth hormone insensitivity.
Reviews in endocrine & metabolic disorders Mar, 2021 | Pubmed ID: 33037595
Differential gene signature in adipose tissue depots of growth hormone transgenic mice.
Journal of neuroendocrinology 11, 2020 | Pubmed ID: 33043505
Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo.
Cancers Dec, 2020 | Pubmed ID: 33291663
Natural Compound α-PGG and Its Synthetic Derivative 6Cl-TGQ Alter Insulin Secretion: Evidence for Diminishing Glucose Uptake as a Mechanism.
Diabetes, metabolic syndrome and obesity : targets and therapy , 2021 | Pubmed ID: 33658814
A small-molecule pan-class I glucose transporter inhibitor reduces cancer cell proliferation in vitro and tumor growth in vivo by targeting glucose-based metabolism.
Cancer & metabolism Mar, 2021 | Pubmed ID: 33771231
Corinne M. Nielsen*,1,2,3,
Yanrong Qian*,4,
Subhodip Adhicary1,5,
Yunsheng Li4,
Pratik Shriwas1,2,4,
Xuan Wang1,2,4,
Lindsey Bachmann6,
Xiaozhuo Chen1,2,4,7
1Department of Biological Sciences, Ohio University,
2Molecular and Cellular Biology Program, Ohio University,
3Neuroscience Program, Ohio University,
4Edison Biotechnology Institute, Ohio University,
5Translational Biomedical Sciences Program, Ohio University,
6Honors Tutorial College, Ohio University,
7Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University