Division of Pulmonary and Critical Care Medicine
Dr. Peggy Lai is a an Assistant Professor of Medicine at HMS, a physician in the Division of Pulmonary and Critical Care Medicine at MGH, and a Research Associate in the Department of Environmental Health at the Harvard T.H. Chan School of Public Health. Her research group (https://www.lai-lab.com/) performs clinical and translational research at the intersection of environmental exposures, the human microbiome, and lung disease. Her work is supported by grants from the National Institutes of Health, the American Lung Association, the American Thoracic Society, and a Transformative Scholars Award from the MGH Department of Medicine.
Dr. Lai earned her MD at Columbia University College of Physicians and Surgeons and her MPH from the Harvard T.H. Chan School of Public Health. She completed her Internal Medicine Residency at New York Presbyterian - Weill Cornell and her Pulmonary and Critical Care fellowship at Massachusetts General Hospital, Brigham and Women's Hospital, and Beth Israel Deaconess Medical Center in Boston.
Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion.
American journal of respiratory cell and molecular biology Aug, 2012 | Pubmed ID: 22517795
An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock.
Minerva anestesiologica Jan, 2013 | Pubmed ID: 23174922
Long-term respiratory health effects in textile workers.
Current opinion in pulmonary medicine Mar, 2013 | Pubmed ID: 23361196
Dynamic data during hypotensive episode improves mortality predictions among patients with sepsis and hypotension.
Critical care medicine Apr, 2013 | Pubmed ID: 23385106
Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin.
PloS one , 2013 | Pubmed ID: 23675439
Why activated protein C was not successful in severe sepsis and septic shock: are we still tilting at windmills?
Current infectious disease reports Oct, 2013 | Pubmed ID: 23925482
Exposures to molds in school classrooms of children with asthma.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology Nov, 2013 | Pubmed ID: 24112429
What is the clinical significance of pulmonary hypertension in acute respiratory distress syndrome? A review.
Minerva anestesiologica May, 2014 | Pubmed ID: 24193181
Gender differences in the effect of occupational endotoxin exposure on impaired lung function and death: the Shanghai Textile Worker Study.
Occupational and environmental medicine Feb, 2014 | Pubmed ID: 24297825
Endotoxin and gender modify lung function recovery after occupational organic dust exposure: a 30-year study.
Occupational and environmental medicine Aug, 2015 | Pubmed ID: 25666844
Alternate methods of nasal epithelial cell sampling for airway genomic studies.
The Journal of allergy and clinical immunology Oct, 2015 | Pubmed ID: 26037550
School Endotoxin Exposure and Asthma Morbidity in Inner-city Children.
Chest Nov, 2015 | Pubmed ID: 26087201
Time-Limited Trials of Intensive Care for Critically Ill Patients With Cancer: How Long Is Long Enough?
JAMA oncology Jan, 2016 | Pubmed ID: 26469222
Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline.
Environmental health perspectives 09, 2016 | Pubmed ID: 27138294
Modeling indoor particulate exposures in inner-city school classrooms.
Journal of exposure science & environmental epidemiology 09, 2017 | Pubmed ID: 27599884
School Environmental Intervention to Reduce Particulate Pollutant Exposures for Children with Asthma.
The journal of allergy and clinical immunology. In practice Jan - Feb, 2017 | Pubmed ID: 27641483
Retrospective Review of the Anaesthetic Management of Maxillectomies and Mandibulectomies for Benign Tumours in Sub-Saharan Africa.
PloS one , 2016 | Pubmed ID: 27788172
Effect of Pre-operative Anaemia on Post-operative Complications in Low-Resource Settings.
World journal of surgery Mar, 2017 | Pubmed ID: 27837236
Association Between Allergen Exposure in Inner-City Schools and Asthma Morbidity Among Students.
JAMA pediatrics 01, 2017 | Pubmed ID: 27893060
The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned.
Contemporary clinical trials 09, 2017 | Pubmed ID: 28619649
Reply.
The journal of allergy and clinical immunology. In practice Jul - Aug, 2017 | Pubmed ID: 28689836
Impact of environmental microbiota on human microbiota of workers in academic mouse research facilities: An observational study.
PloS one , 2017 | Pubmed ID: 28704437
Gene-environment interaction between an IL4R variant and school endotoxin exposure contributes to asthma symptoms in inner-city children.
The Journal of allergy and clinical immunology 02, 2018 | Pubmed ID: 28943468
Nitrogen dioxide exposure in school classrooms of inner-city children with asthma.
The Journal of allergy and clinical immunology 06, 2018 | Pubmed ID: 28988796
The classroom microbiome and asthma morbidity in children attending 3 inner-city schools.
The Journal of allergy and clinical immunology 06, 2018 | Pubmed ID: 29518428
Epidemiology of antibiotic-resistant wound infections from six countries in Africa.
BMJ global health , 2017 | Pubmed ID: 29588863
Impact of occupational exposure on human microbiota.
Current opinion in allergy and clinical immunology 04, 2019 | Pubmed ID: 30507717
Association between fungal spore exposure in inner-city schools and asthma morbidity.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 06, 2019 | Pubmed ID: 30904580
The nasal methylome as a biomarker of asthma and airway inflammation in children.
Nature communications 07, 2019 | Pubmed ID: 31300640
Personal carbon monoxide exposure, respiratory symptoms, and the potentially modifying roles of sex and HIV infection in rural Uganda: a cohort study.
Environmental health : a global access science source 08, 2019 | Pubmed ID: 31429759
Proximity to major roadways and asthma symptoms in the School Inner-City Asthma Study.
The Journal of allergy and clinical immunology 01, 2020 | Pubmed ID: 31557500
Pulmonary Infarction due to Paget-Schroetter Syndrome and Nephrotic Syndrome.
The American journal of case reports Nov, 2019 | Pubmed ID: 31727870
Obesity may enhance the adverse effects of NO exposure in urban schools on asthma symptoms in children.
The Journal of allergy and clinical immunology 10, 2020 | Pubmed ID: 32197971
Differential Effect of School-Based Pollution Exposure in Children With Asthma Born Prematurely.
Chest 10, 2020 | Pubmed ID: 32450239
Gut carriage of antimicrobial resistance genes in women exposed to small-scale poultry farms in rural Uganda: A feasibility study.
PloS one , 2020 | Pubmed ID: 32525954
Impact of DNA Extraction Method on Variation in Human and Built Environment Microbial Community and Functional Profiles Assessed by Shotgun Metagenomics Sequencing.
Frontiers in microbiology , 2020 | Pubmed ID: 32528434
Asthma Prevalence and Mold Levels in US Northeastern Schools.
The journal of allergy and clinical immunology. In practice 03, 2021 | Pubmed ID: 33091637
Indoor Microbial Exposures and Chronic Lung Disease: From Microbial Toxins to the Microbiome.
Clinics in chest medicine 12, 2020 | Pubmed ID: 33153695
Occupational and Environmental Contributions to Lung Disease.
Clinics in chest medicine 12, 2020 | Pubmed ID: 33153699
Preventing asthma in high risk kids (PARK) with omalizumab: Design, rationale, methods, lessons learned and adaptation.
Contemporary clinical trials 01, 2021 | Pubmed ID: 33242697
Notch4 signaling limits regulatory T-cell-mediated tissue repair and promotes severe lung inflammation in viral infections.
Immunity 06, 2021 | Pubmed ID: 33915108
Detection of Food Allergens in School and Home Environments of Elementary Students.
The journal of allergy and clinical immunology. In practice Jun, 2021 | Pubmed ID: 34174494
Jacob Vieira1,
Tara Gallagher2,
Hui-Yu Sui1,
Sirus Jesudasen3,
Katrine Whiteson2,
George A. O'Toole4,
Kurt Hanselmann5,
Peggy S. Lai1
1Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital,
2Department of Molecular Biology & Biochemistry, University of California, Irvine,
3Department of Medicine, Massachusetts General Hospital,
4Department of Microbiology & Immunology, Geisel School of Medicine at Dartmouth,
5, Swiss i-research and teaching institute