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Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat.
Neurobiology of disease Sep, 2011 | Pubmed ID: 21600984
Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model.
Molecular therapy : the journal of the American Society of Gene Therapy Oct, 2011 | Pubmed ID: 22008908
Subthalamic Nucleus Stimulation Increases Brain Derived Neurotrophic Factor in the Nigrostriatal System and Primary Motor Cortex.
Journal of Parkinson's disease May, 2011 | Pubmed ID: 22328911
Anatomy of Graft-induced Dyskinesias: Circuit Remodeling in the Parkinsonian Striatum.
Basal ganglia Mar, 2012 | Pubmed ID: 22712056
Advances in thin tissue Golgi-Cox impregnation: fast, reliable methods for multi-assay analyses in rodent and non-human primate brain.
Journal of neuroscience methods Mar, 2013 | Pubmed ID: 23313849
Aberrant restoration of spines and their synapses in L-DOPA-induced dyskinesia: involvement of corticostriatal but not thalamostriatal synapses.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jul, 2013 | Pubmed ID: 23843533
Chronic amitriptyline treatment attenuates nigrostriatal degeneration and significantly alters trophic support in a rat model of parkinsonism.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology Mar, 2015 | Pubmed ID: 25267343
Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain.
Neurobiology of aging Feb, 2015 | Pubmed ID: 25457558
Interrogating the aged striatum: robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration.
Neurobiology of disease May, 2015 | Pubmed ID: 25771169
The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes.
PloS one , 2015 | Pubmed ID: 25992874
Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration.
Neurobiology of disease Oct, 2015 | Pubmed ID: 26093169
Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease.
Progress in neurobiology Sep, 2015 | Pubmed ID: 26209473
High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.
PloS one , 2015 | Pubmed ID: 26222442
Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.
PloS one , 2015 | Pubmed ID: 26340267
Loss of VGLUT3 Produces Circadian-Dependent Hyperdopaminergia and Ameliorates Motor Dysfunction and l-Dopa-Mediated Dyskinesias in a Model of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience Nov, 2015 | Pubmed ID: 26558771
Impact of age and vector construct on striatal and nigral transgene expression.
Molecular therapy. Methods & clinical development , 2016 | Pubmed ID: 27933309
Repairing the Aged Parkinsonian Striatum: Lessons from the Lab and Clinic.
Journal of clinical & cellular immunology Dec, 2016 | Pubmed ID: 28111608
Subthalamic Nucleus Deep Brain Stimulation Employs trkB Signaling for Neuroprotection and Functional Restoration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 07, 2017 | Pubmed ID: 28607168
Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression.
Scientific reports Nov, 2017 | Pubmed ID: 29180681
Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia.
Acta neuropathologica communications 01, 2019 | Pubmed ID: 30646956
Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia.
Movement disorders : official journal of the Movement Disorder Society 05, 2019 | Pubmed ID: 31002755
Cell therapy for Parkinson's disease: Why it doesn't work every time.
Movement disorders : official journal of the Movement Disorder Society 08, 2019 | Pubmed ID: 31234239
Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 04, 2020 | Pubmed ID: 32238479
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats.
Experimental neurology 08, 2020 | Pubmed ID: 32387398
Preclinical evidence in support of repurposing sub-anesthetic ketamine as a treatment for L-DOPA-induced dyskinesia.
Experimental neurology 11, 2020 | Pubmed ID: 32717354
The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats.
Neurobiology of disease Jan, 2021 | Pubmed ID: 33188920
Striatal afferent BDNF is disrupted by synucleinopathy and partially restored by STN DBS.
The Journal of neuroscience : the official journal of the Society for Neuroscience Jan, 2021 | Pubmed ID: 33472823
α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.
JCI insight 03, 2021 | Pubmed ID: 33682798