Kullervo Hynynen

Focal beam distortion and treatment planning in abdominal focused ultrasound surgery.

Effects of parameter errors in the simulation of transcranial focused ultrasound.

The use of quantitative temperature images to predict the optimal power for focused ultrasound surgery: in vivo verification in rabbit muscle and brain.

The temperature dependence of ultrasound-stimulated acoustic emission.

Micro-receiver guided transcranial beam steering.

Magnetic resonance image-guided focused ultrasound surgery.

Correlation of ultrasound phase with physical skull properties.

Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia.

Bio-acoustic thermal lensing and nonlinear propagation in focused ultrasound surgery using large focal spots: a parametric study.

A unified model for the speed of sound in cranial bone based on genetic algorithm optimization.

Interlaboratory acoustic power measurement.

MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study.

Intraoperative magnetic resonance imaging and magnetic resonance imaging-guided therapy for brain tumors.

The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison).

MRI-guided focused ultrasound surgery in the brain: tests in a primate model.

The use of ultrasound-stimulated acoustic emission in the monitoring of modulus changes with temperature.

Ultrasound-mediated cavitation thresholds of liquid perfluorocarbon droplets in vitro.

Localized harmonic motion imaging: theory, simulations and experiments.

Modeling of anomalies due to hydrophones in continuous-wave ultrasound fields.

Forward planar projection through layered media.

Heat-activated liposomal MR contrast agent: initial in vivo results in rabbit liver and kidney.

Optical monitoring of ultrasound-induced bioeffects in glass catfish.

MRI investigation of the threshold for thermally induced blood-brain barrier disruption and brain tissue damage in the rabbit brain.

MRI monitoring of heating produced by ultrasound absorption in the skull: in vivo study in pigs.

Simulation study for thermal dose optimization in ultrasound surgery of the breast.

Apoptosis signals in lymphoblasts induced by focused ultrasound.

500-element ultrasound phased array system for noninvasive focal surgery of the brain: a preliminary rabbit study with ex vivo human skulls.

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles.

Patterns of thermal deposition in the skull during transcranial focused ultrasound surgery.

Noninvasive thermal ablation of hepatocellular carcinoma by using magnetic resonance imaging-guided focused ultrasound.

Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications.

A numerical study of transcranial focused ultrasound beam propagation at low frequency.

A full-wave Helmholtz model for continuous-wave ultrasound transmission.

Intracellular delivery of Bak BH3 peptide by microbubble-enhanced ultrasound.

A new ultrasound method for determining the acoustic phase shifts caused by the skull bone.

MRI-guided ultrasonic heating allows spatial control of exogenous luciferase in canine prostate.

Scanning path optimization for ultrasound surgery.

A magnetic resonance imaging-compatible, large-scale array for trans-skull ultrasound surgery and therapy.

A novel method for the intracellular delivery of siRNA using microbubble-enhanced focused ultrasound.

MR imaging-controlled focused ultrasound ablation: a noninvasive image-guided surgery.

Feasibility of internally referenced brain temperature imaging with a metabolite signal.

Acoustic transmission losses and field alterations due to human scalp hair.

Hyperthermia combined with radiation in treatment of locally advanced prostate cancer is associated with a favourable toxicity profile.

Transcranial ultrasound focus reconstruction with phase and amplitude correction.

MRI-guided targeted blood-brain barrier disruption with focused ultrasound: histological findings in rabbits.

Targeted delivery of antibodies through the blood-brain barrier by MRI-guided focused ultrasound.

Mechanism of porphyrin-induced sonodynamic effect: possible role of hyperthermia.

Multiphoton imaging of ultrasound/Optison mediated cerebrovascular effects in vivo.

Pre-clinical testing of a phased array ultrasound system for MRI-guided noninvasive surgery of the brain--a primate study.

Does the phase of menstrual cycle affect MR-guided focused ultrasound surgery of uterine leiomyomas?

Uterine leiomyomas: MR imaging-based thermometry and thermal dosimetry during focused ultrasound thermal ablation.

Noninvasive transesophageal cardiac thermal ablation using a 2-D focused, ultrasound phased array: a simulation study.

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood-brain barrier disruption.

Ultrasound stimulates proteoglycan synthesis in bovine primary chondrocytes.

Simulations of localized harmonic motions on a blood vessel wall induced by an acoustic radiation force used in ultrasound elastography.

Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.

Brain arterioles show more active vesicular transport of blood-borne tracer molecules than capillaries and venules after focused ultrasound-evoked opening of the blood-brain barrier.

Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits.

Image-guided neurosurgery at Brigham and Women's Hospital.

Investigation of optimal method for inducing harmonic motion in tissue using a linear ultrasound phased array--a simulation study.

Quality assurance and system stability of a clinical MRI-guided focused ultrasound system: four-year experience.

Induction of apoptosis in vivo in the rabbit brain with focused ultrasound and Optison.

Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain.

Activation of Bak in ultrasound-induced, JNK- and p38-independent apoptosis and its inhibition by Bcl-2.

Modular design for in vivo optical imaging and ultrasound treatment in the murine brain.

Use of ultrasound pulses combined with Definity for targeted blood-brain barrier disruption: a feasibility study.

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound.

A novel phase assignment protocol and driving system for a high-density focused ultrasound array.

Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--results of different treatment protocols.

Chemotherapy delivery issues in central nervous system malignancy: a reality check.

Key factors that affect sonoporation efficiency in in vitro settings: the importance of standing wave in sonoporation.

Clinical applications of focused ultrasound-the brain.

Cavitation threshold of microbubbles in gel tunnels by focused ultrasound.

Circumferential lesion formation around the pulmonary veins in the left atrium with focused ultrasound using a 2D-array endoesophageal device: a numerical study.

The effects of desiccation on skull bone sound speed in porcine models.

A computer-controlled ultrasound pulser-receiver system for transskull fluid detection using a shear wave transmission technique.

Temperature mapping considerations in the breast with line scan echo planar spectroscopic imaging.

Treatment of near-skull brain tissue with a focused device using shear-mode conversion: a numerical study.

Progress in multimodality imaging: truly simultaneous ultrasound and magnetic resonance imaging.

Blood-brain barrier disruption induced by focused ultrasound and circulating preformed microbubbles appears to be characterized by the mechanical index.

Effects of acoustic parameters and ultrasound contrast agent dose on focused-ultrasound induced blood-brain barrier disruption.

Fetal thermal effects of diagnostic ultrasound.

Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium.

Ultrasound enhanced delivery of molecular imaging and therapeutic agents in Alzheimer's disease mouse models.

Ultrasound for drug and gene delivery to the brain.

Progress and problems in the application of focused ultrasound for blood-brain barrier disruption.

Uterine leiomyomas: MR imaging-guided focused ultrasound surgery--imaging predictors of success.

Simulations of lesion detection using a combined phased array LHMI-technique.

In vivo monitoring of focused ultrasound surgery using local harmonic motion.

Evaluation of referenceless thermometry in MRI-guided focused ultrasound surgery of uterine fibroids.

Genome-wide microarray analysis of MG-63 osteoblastic cells exposed to ultrasound.

Macromolecular delivery across the blood-brain barrier.

Transcranial shear-mode ultrasound: assessment of imaging performance and excitation techniques.

MRI-based thermal dosimetry and diffusion-weighted imaging of MRI-guided focused ultrasound thermal ablation of uterine fibroids.

Lateral mode coupling to reduce the electrical impedance of small elements required for high power ultrasound therapy phased arrays.

New design for an endoesophageal sector- based array for the treatment of atrial fibrillation: a parametric simulation study.

Focused ultrasound treatment of VX2 tumors controlled by local harmonic motion.

An MRI-compatible system for focused ultrasound experiments in small animal models.

MR acoustic radiation force imaging: in vivo comparison to ultrasound motion tracking.

Focused ultrasound effects on nerve action potential in vitro.

Feasibility of using lateral mode coupling method for a large scale ultrasound phased array for noninvasive transcranial therapy.

MRI-guided focused ultrasound treatments.

Local harmonic motion monitoring of focused ultrasound surgery--a simulation model.

Transcranial magnetic resonance imaging- guided focused ultrasound surgery of brain tumors: initial findings in 3 patients.

Hyperthermia classic commentary: 'A scanned, focused, multiple transducer ultrasonic system for localised hyperthermia treatments', by K. Hynynen, R. Roemer, D. Anhalt, et al., International Journal of Hyperthermia 1987;3:21-35.

Temperature change near microbubbles within a capillary network during focused ultrasound.

Ultrasound-induced activation of Wnt signaling in human MG-63 osteoblastic cells.

Contrast agent kinetics in the rabbit brain during exposure to therapeutic ultrasound.

Antibodies targeted to the brain with image-guided focused ultrasound reduces amyloid-beta plaque load in the TgCRND8 mouse model of Alzheimer's disease.

A PVDF receiver for ultrasound monitoring of transcranial focused ultrasound therapy.

Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures.

In vitro characterization of perfluorocarbon droplets for focused ultrasound therapy.

The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model.

Hyperthermia combined with radiation for the treatment of locally advanced prostate cancer: long-term results from Dana-Farber Cancer Institute study 94-153.

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats.

Multi-frequency characterization of the speed of sound and attenuation coefficient for longitudinal transmission of freshly excised human skulls.

Localised drug release using MRI-controlled focused ultrasound hyperthermia.

MR-guided focused ultrasound for brain ablation and blood-brain barrier disruption.

Focused-ultrasound disruption of the blood-brain barrier using closely-timed short pulses: influence of sonication parameters and injection rate.

Focused ultrasound surgery in oncology: overview and principles.

Two-photon fluorescence microscopy study of cerebrovascular dynamics in ultrasound-induced blood-brain barrier opening.

Localized harmonic motion imaging for focused ultrasound surgery targeting.

Simulations and measurements of transcranial low-frequency ultrasound therapy: skull-base heating and effective area of treatment.

The utility of sparse 2D fully electronically steerable focused ultrasound phased arrays for thermal surgery: a simulation study.

Ultrafast 1D MR thermometry using phase or frequency mapping.

Ultrasound insertion loss of rat parietal bone appears to be proportional to animal mass at submegahertz frequencies.

Investigation of standing-wave formation in a human skull for a clinical prototype of a large-aperture, transcranial MR-guided focused ultrasound (MRgFUS) phased array: an experimental and simulation study.

Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood-brain barrier.

Pulsed focused ultrasound-induced displacements in confined in vitro blood clots.

Focused ultrasound disruption of the blood-brain barrier: a new frontier for therapeutic delivery in molecular neurooncology.

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions-based Controller.

Hyperthermia in Bone Generated with MR Imaging-controlled Focused Ultrasound: Control Strategies and Drug Delivery.

Driving circuitry for focused ultrasound noninvasive surgery and drug delivery applications.

Enhanced delivery of gold nanoparticles with therapeutic potential into the brain using MRI-guided focused ultrasound.

In Vitro and In Vivo High-Intensity Focused Ultrasound Thrombolysis.

Hyperthermia in bone generated with MR imaging-controlled focused ultrasound: control strategies and drug delivery.

Overview of therapeutic ultrasound applications and safety considerations.

Ultrasound enhanced drug delivery to the brain and central nervous system.

The design of a focused ultrasound transducer array for the treatment of stroke: a simulation study.

Improved anti-tumor effect of liposomal doxorubicin after targeted blood-brain barrier disruption by MRI-guided focused ultrasound in rat glioma.

Targeted delivery of self-complementary adeno-associated virus serotype 9 to the brain, using magnetic resonance imaging-guided focused ultrasound.

High-intensity focused ultrasound (HIFU) for dissolution of clots in a rabbit model of embolic stroke.

MRIgHIFU: a tool for image-guided therapeutics.

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression.

Enhanced drug delivery in rabbit VX2 tumours using thermosensitive liposomes and MRI-controlled focused ultrasound hyperthermia.

Contrast-enhanced transcranial two-dimensional ultrasound imaging using shear-mode conversion at low frequency.

Antitumor effects of combining docetaxel (taxotere) with the antivascular action of ultrasound stimulated microbubbles.

Focused ultrasound delivers targeted immune cells to metastatic brain tumors.

Noninvasive and targeted drug delivery to the brain using focused ultrasound.

Enhancing drug delivery for boron neutron capture therapy of brain tumors with focused ultrasound.

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound.

Creating brain lesions with low-intensity focused ultrasound with microbubbles: a rat study at half a megahertz.

Transcranial passive acoustic mapping with hemispherical sparse arrays using CT-based skull-specific aberration corrections: a simulation study.

Drug delivery to the brain by focused ultrasound induced blood-brain barrier disruption: quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy.

Cavitation-based third ventriculostomy using MRI-guided focused ultrasound.

The evaluation of steerable ultrasonic catheters for minimally invasive MRI-guided cardiac ablation.

A super-resolution ultrasound method for brain vascular mapping.

The application of sparse arrays in high frequency transcranial focused ultrasound therapy: a simulation study.

Focused ultrasound delivery of Raman nanoparticles across the blood-brain barrier: potential for targeting experimental brain tumors.

Numerical simulations of clinical focused ultrasound functional neurosurgery.

Stimulation of hippocampal neurogenesis by transcranial focused ultrasound and microbubbles in adult mice.

Drug delivery across the blood-brain barrier using focused ultrasound.

Three-dimensional transcranial ultrasound imaging of microbubble clouds using a sparse hemispherical array.

Intracranial applications of magnetic resonance-guided focused ultrasound.

A non-surgical model of cervical spinal cord injury induced with focused ultrasound and microbubbles.

Simulation study of the effects of near- and far-field heating during focused ultrasound uterine fibroid ablation using an electronically focused phased array: A theoretical analysis of patient safety.

High-intensity focused ultrasound sonothrombolysis: the use of perfluorocarbon droplets to achieve clot lysis at reduced acoustic power.

Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy.

Alzheimer disease in a mouse model: MR imaging-guided focused ultrasound targeted to the hippocampus opens the blood-brain barrier and improves pathologic abnormalities and behavior.

Modeling localized delivery of Doxorubicin to the brain following focused ultrasound enhanced blood-brain barrier permeability.

Microbubbles and blood-brain barrier opening: a numerical study on acoustic emissions and wall stress predictions.

Hyperthermia-mediated doxorubicin release from thermosensitive liposomes using MR-HIFU: therapeutic effect in rabbit Vx2 tumours.

A novel, flat, electronically-steered phased array transducer for tissue ablation: preliminary results.

Gene delivery to the spinal cord using MRI-guided focused ultrasound.

Emerging non-cancer applications of therapeutic ultrasound.

Focused ultrasound-mediated drug delivery through the blood-brain barrier.

Quantitative MRI in a non-surgical model of cervical spinal cord injury.

Experimental demonstration of passive acoustic imaging in the human skull cavity using CT-based aberration corrections.

Frequency considerations for deep ablation with high-intensity focused ultrasound: A simulation study.

Combined Therapeutic and Monitoring Ultrasonic Catheter for Cardiac Ablation Therapies.

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System.

Comparison of analytical and numerical approaches for CT-based aberration correction in transcranial passive acoustic imaging.

A review of ablative techniques in the treatment of breast fibroadenomata.

Early treatment of HER2-amplified brain tumors with targeted NK-92 cells and focused ultrasound improves survival.

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound.

Magnetic resonance-guided high-intensity focused ultrasound combined with radiotherapy for palliation of head and neck cancer-a pilot study.

Magnetic Resonance-Guided High-Intensity Focused Ultrasound Hyperthermia for Recurrent Rectal Cancer: MR Thermometry Evaluation and Preclinical Validation.

Opening the Blood-Brain Barrier with MR Imaging-guided Focused Ultrasound: Preclinical Testing on a Trans-Human Skull Porcine Model.

Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability.

Magnetic Resonance-Guided High-Intensity-Focused Ultrasound for Palliation of Painful Skeletal Metastases: A Pilot Study.

Image-guided ultrasound phased arrays are a disruptive technology for non-invasive therapy.

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor.

Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array.

A numerical study on the oblique focus in MR-guided transcranial focused ultrasound.

A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping.

A Tikhonov Regularization Scheme for Focus Rotations With Focused Ultrasound-Phased Arrays.

Blood-Brain Barrier Closure Time After Controlled Ultrasound-Induced Opening Is Independent of Opening Volume.

To heat or not to heat: Challenges with clinical translation of thermosensitive liposomes.

Urinary cytokines/chemokines after magnetic resonance-guided high intensity focused ultrasound for palliative treatment of painful bone metastases.

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome.

Focused ultrasound as a novel strategy for Alzheimer disease therapeutics.

A computerized tablet system for evaluating treatment of essential tremor by magnetic resonance guided focused ultrasound.

Design of a HIFU array for the treatment of deep venous thrombosis: a simulation study.

Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range.

A viscoelastic model for the prediction of transcranial ultrasound propagation: application for the estimation of shear acoustic properties in the human skull.

Megahertz rate, volumetric imaging of bubble clouds in sonothrombolysis using a sparse hemispherical receiver array.

Focused Ultrasound Hyperthermia Mediated Drug Delivery Using Thermosensitive Liposomes and Visualized With Two-Photon Microscopy.

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging.

Investigating the efficacy of a combination Aβ-targeted treatment in a mouse model of Alzheimer's disease.

Acute Inflammatory Response Following Increased Blood-Brain Barrier Permeability Induced by Focused Ultrasound is Dependent on Microbubble Dose.

Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.

Reply to Kovacs .: Concerning acute inflammatory response following focused ultrasound and microbubbles in the brain.

Skull bone marrow injury caused by MR-guided focused ultrasound for cerebral functional procedures.

Brainstem blood brain barrier disruption using focused ultrasound: A demonstration of feasibility and enhanced doxorubicin delivery.

The reduction in treatment efficiency at high acoustic powers during MR-guided transcranial focused ultrasound thalamotomy for Essential Tremor.

An MR-based quantitative intraventricular hemorrhage porcine model for MR-guided focused ultrasound thrombolysis.

Three-dimensional transcranial microbubble imaging for guiding volumetric ultrasound-mediated blood-brain barrier opening.

Preliminary Investigation of Focused Ultrasound-Facilitated Drug Delivery for the Treatment of Leptomeningeal Metastases.

Microbubble Localization for Three-Dimensional Superresolution Ultrasound Imaging Using Curve Fitting and Deconvolution Methods.

Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound.

Ultrasound and Microbubble-Mediated Blood-Brain Barrier Disruption for Targeted Delivery of Therapeutics to the Brain.

Predicting lesion size by accumulated thermal dose in MR-guided focused ultrasound for essential tremor.

Angiogenic response of rat hippocampal vasculature to focused ultrasound-mediated increases in blood-brain barrier permeability.

Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease.

Noninvasive delivery of an α-synuclein gene silencing vector with magnetic resonance-guided focused ultrasound.

Magnetic resonance-guided focused ultrasound thalamotomy for treatment of essential tremor: A 2-year outcome study.

Microbubble-assisted MRI-guided focused ultrasound for hyperthermia at reduced power levels.

Enhancing Checkpoint Inhibitor Therapy with Ultrasound Stimulated Microbubbles.

Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor.

Receiver array design for sonothrombolysis treatment monitoring in deep vein thrombosis.

Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability.

Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study.

MRI-Guided Focused Ultrasound for Targeted Delivery of rAAV to the Brain.

Hyperthermia-induced drug delivery in humans.

The relevance of skull density ratio in selecting candidates for transcranial MR-guided focused ultrasound.

Accumulated thermal dose in MRI-guided focused ultrasound for essential tremor: repeated sonications with low focal temperatures.

Acoustic radiation force induced accumulation and dynamics of microbubbles on compliant surfaces.

Resting state functional connectivity changes after MR-guided focused ultrasound mediated blood-brain barrier opening in patients with Alzheimer's disease.

Transcranial Photoacoustic Detection of Blood-Brain Barrier Disruption Following Focused Ultrasound-Mediated Nanoparticle Delivery.

MR-guided Focused Ultrasound Facilitates Sonodynamic Therapy with 5-Aminolevulinic Acid in a Rat Glioma Model.

Safety and efficacy of focused ultrasound induced blood-brain barrier opening, an integrative review of animal and human studies.

Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.

First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound.

Tractography-based targeting of the ventral intermediate nucleus: accuracy and clinical utility in MRgFUS thalamotomy.

Strategy to enhance transgene expression in proximity of amyloid plaques in a mouse model of Alzheimer's disease.

Super-resolution Ultrasound Imaging.

A Noninvasive Ultrasound Resonance Method for Detecting Skull Induced Phase Shifts May Provide a Signal for Adaptive Focusing.

Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure.

Ultrasound-Responsive Cavitation Nuclei for Therapy and Drug Delivery.

Localized anesthesia of a specific brain region using ultrasound-responsive barbiturate nanodroplets.

Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia.

Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation.

Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials.

Ultrafast three-dimensional microbubble imaging predicts tissue damage volume distributions during nonthermal brain ablation.

Echo-Focusing in Transcranial Focused Ultrasound Thalamotomy for Essential Tremor: A Feasibility Study.

Novel fractionated ultrashort thermal exposures with MRI-guided focused ultrasound for treating tumors with thermosensitive drugs.

Technical and radiographic considerations for magnetic resonance imaging-guided focused ultrasound capsulotomy.

Comparing rapid short-pulse to tone burst sonication sequences for focused ultrasound and microbubble-mediated blood-brain barrier permeability enhancement.

Applications of focused ultrasound in the brain: from thermoablation to drug delivery.

MRI-guided focused ultrasound enhances drug delivery in experimental diffuse intrinsic pontine glioma.

Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability and behavior.

Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer's disease.

Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain.

Technical Principles and Clinical Workflow of Transcranial MR-Guided Focused Ultrasound.

Perfusion fixation methods for preclinical biodistribution studies: A comparative assessment using automated image processing.

Focused Ultrasound and Microbubbles-Mediated Drug Delivery to Brain Tumor.

Vasculotide restores the blood-brain barrier after focused ultrasound-induced permeability in a mouse model of Alzheimer's disease.

Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments.

Novel Treatment Approaches for Brain Tumour from a Blood-Brain Barrier Perspective.

Systemic AAV6-synapsin-GFP administration results in lower liver biodistribution, compared to AAV1&2 and AAV9, with neuronal expression following ultrasound-mediated brain delivery.

Ultrasound-sensitive nanodroplets achieve targeted neuromodulation.

MR-guided focused ultrasound liquid biopsy enriches circulating biomarkers in patients with brain tumors.

Therapeutic Agent Delivery Across the Blood-Brain Barrier Using Focused Ultrasound.

Corrigendum: Perfusion fixation methods for preclinical biodistribution studies: a comparative assessment using automated image processing (2021 017001).

Erratum: "Registration of human skull computed tomography data to an ultrasound treatment space using a sparse high frequency ultrasound hemispherical array" [Med. Phys. 43, 5063-5071 (2016)].

The mechanical potential of ultrasound on nervous tissue.

Intravenous and Non-invasive Drug Delivery to the Mouse Basal ForebrainUsing MRI-guided Focused Ultrasound.

Focused ultrasound neuromodulation.

Sub-millimetre precision of drug delivery in the brain from ultrasound-triggered nanodroplets.

Comparison of computer simulations and clinical treatment results of magnetic resonance guided focused ultrasound surgery (MRgFUS) of uterine fibroids.

MR-guided focused ultrasound enhances delivery of trastuzumab to Her2-positive brain metastases.

Transgene distribution and immune response after ultrasound delivery of rAAV9 and PHP.B to the brain in a mouse model of amyloidosis.

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies.

Targeted Nanoparticle for Co-delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis.