Lin-Tai Da

Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.

Inhibition of polypeptide N-acetyl-α-galactosaminyltransferases is an underlying mechanism of dietary polyphenols preventing colorectal tumorigenesis.

Characterization and Nonenzymatic Transformation of Three Types of Alkaloids from MGR072 and Discovery of Inhibitors of Indoleamine 2,3-Dioxygenase.

Opening dynamics of HIV-1 gp120 upon receptor binding is dictated by a key hydrophobic core.

Rational engineering of amide synthetase enables bioconversion to diverse xiamenmycin derivatives.

Refolding Dynamics of gp41 from Pre-fusion to Pre-hairpin States during HIV-1 Entry.

Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2.

Key structural motifs in Thymine DNA glycosylase responsible for recognizing certain DNA bent conformation revealed by atomic simulations.

DeepAntigen: a novel method for neoantigen prioritization via 3D genome and deep sparse learning.

A novel neoantigen discovery approach based on chromatin high order conformation.

Atomic resolution of short-range sliding dynamics of thymine DNA glycosylase along DNA minor-groove for lesion recognition.

Mechanism of REST/NRSF regulation of clustered protocadherin α genes.

RQC helical hairpin in Bloom's syndrome helicase regulates DNA unwinding by dynamically intercepting nascent nucleotides.

Early aggregation mechanism of Aβ revealed by Markov state models.