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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma

Melasma, a common, acquired facial pigmentation skin disorder, presents a straightforward clinical diagnosis but poses challenges in terms of effective ...

Huazhong University of Science and Technology

Wuhan No.1 Hospital

To study the toll-like receptor 2 (TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome, thus laying the foundation for genetics studies on its occurrence.

[Analysis of the toll-like receptor 2 Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome].

This aim of this study was to observe the effect of Yang Yan Qing E Wan (YYQEW) on senescent phenotypes and the expression of β-catenin and p16 in the hydrogen peroxide (HO)-induced premature senescence of normal human skin fibroblasts (NHSFs). Primary normal human skin fibroblasts were randomly divided into a normal group, a blank group, a model group, and a YYQEW group. The cells of the model group and the YYQEW group were exposed to 150 μmol/L HO for 2 h. The morphological changes of the cells were analyzed by microscopy and by kits used to estimate the activities of the senescence-associated β-galactosidase (SA-β-gal), reactive oxygen species (ROS), and superoxide dismutase (SOD). The outcomes revealed that dyeing rate proportion of SA-β-gal was 2.78% ± 0.22% in the normal group, 2.83% ± 0.29% in the blank group, 37.58% ± 2.56% in the model group, and 28.39% ± 0.93% in the YYQEW group. The number of SA-β-gal positive cells was thus significantly higher in the model group than in the normal or blank group. There were also fewer SA-β-gal positive cells in the YYQEW group compared with the model group. The expression of ROS and p16 in the model group increased significantly compared with that in the normal or blank groups, while the expression of ROS and p16 in the YYQEW group decreased significantly compared with that in the model group. The expression of SOD and β-catenin in the model group decreased significantly compared with that in the normal or blank group, and the expression of SOD and β-catenin in the YYQEW group increased significantly compared with that in the model group. Overall, it was found that YYQEW was able to delay the senescence of NHSFs induced by HO treatment by alleviating oxidative stress and regulating a number of senescence-related molecules, such as β-catenin and p16.

The effect of Yang Yan Qing E Wan on senescent phenotypes and the expression of β-catenin and p16 in human skin fibroblasts.

To study the relationship between the single nucleotide polymorphisms (SNPs) of the human β-defensin 1-gene (DEFB1) and the genetic susceptibility of acne vulgaris in the Han Chinese ethnic group.

Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients.

Androgens acting through the androgen receptor play a crucial role in the pathogenesis of acne. This study aimed to identify whether two key genes ( and ) involved in the synthesis and metabolism of androgens were associated with Pillsbury III-IV severe acne vulgaris.

The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China.

Artesunate, a semi-synthetic derivative of artemisinin, exerts various pharmacological activities. Nevertheless, the effects of Art on skin photoaging remain unclear. Herein, we investigated whether Art ameliorated ultraviolet-irradiated skin photoaging in HaCaT cells and mice.

Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression.

The aim of this study was to use network pharmacology to explore the potential targets and mechanisms of action of Qibao Meiran Dan in relation to delaying skin aging.

A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging.

Effects of Qi-Bao-Mei-Ran-Dan on proliferative activity and expressions of apoptosis-related genes Bcl-2, Bax and autophagy-related protein LC3II in fibroblasts of aging skin.

To study the efficacy of Ba Zhen Tang in delaying skin photoaging and its potential mechanism based on network pharmacology and molecular docking.

Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking.

To investigate the variation of ferroptosis-related markers in HaCaT cell photoaging models induced by ultraviolet-B (UVB).

Article	Year
[Analysis of the toll-like receptor 2 Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine\| PubMed ID: 22500392	2012
The effect of Yang Yan Qing E Wan on senescent phenotypes and the expression of β-catenin and p16 in human skin fibroblasts. Journal of tissue viability\| PubMed ID: 32768331	2020
Acne Vulgaris is Associated with the Human β-Defensin 1-Gene Polymorphisms in Han Chinese Ethnic Group Patients. Clinical, cosmetic and investigational dermatology\| PubMed ID: 33568929	2021
The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China. Clinical, cosmetic and investigational dermatology\| PubMed ID: 33824600	2021
Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression. Aging\| PubMed ID: 34887359	2021
A network pharmacology-based study of the potential targets and mechanisms of action of Qibao Meiran Dan in delaying skin aging. Journal of cosmetic dermatology\| PubMed ID: 35274812	2022
Effects of Qi-Bao-Mei-Ran-Dan on proliferative activity and expressions of apoptosis-related genes Bcl-2, Bax and autophagy-related protein LC3II in fibroblasts of aging skin. Asian journal of surgery\| PubMed ID: 35367098	2022
Mechanism of Ba Zhen Tang Delaying Skin Photoaging Based on Network Pharmacology and Molecular Docking. Clinical, cosmetic and investigational dermatology\| PubMed ID: 35510223	2022
Variation of Ferroptosis-Related Markers in HaCaT Cell Photoaging Models Induced by UVB. Clinical, cosmetic and investigational dermatology\| PubMed ID: 37937317	2023

Liming Tian

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