Division of Endocrinology and Metabolism
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Adipose triglyceride lipase deficiency causes tissue-specific changes in insulin signaling.
The Journal of biological chemistry Oct, 2009 | Pubmed ID: 19723629
Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome.
Journal of lipid research Feb, 2011 | Pubmed ID: 21068004
Transcriptional control of adipose lipid handling by IRF4.
Cell metabolism Mar, 2011 | Pubmed ID: 21356515
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.
Nature medicine Aug, 2011 | Pubmed ID: 21857651
Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction.
Molecular and cellular biology , | Pubmed ID: 22158969
Adiponutrin functions as a nutritionally regulated lysophosphatidic acid acyltransferase.
Cell metabolism May, 2012 | Pubmed ID: 22560221
Regulation of insulin and leptin signaling by muscle suppressor of cytokine signaling 3 (SOCS3).
PloS one , 2012 | Pubmed ID: 23115649
Adipose triglyceride lipase is a TG hydrolase of the small intestine and regulates intestinal PPARα signaling.
Journal of lipid research Feb, 2013 | Pubmed ID: 23220585
Myocardial adipose triglyceride lipase overexpression protects diabetic mice from the development of lipotoxic cardiomyopathy.
Diabetes , | Pubmed ID: 23349479
Early structural and metabolic cardiac remodelling in response to inducible adipose triglyceride lipase ablation.
Cardiovascular research , | Pubmed ID: 23708736
Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.
Diabetes Oct, 2013 | Pubmed ID: 23835334
Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation.
Journal of lipid research Nov, 2014 | Pubmed ID: 25193997
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
Journal of hepatology Aug, 2015 | Pubmed ID: 25733154
Adipose triglyceride lipase deletion from adipocytes, but not skeletal myocytes, impairs acute exercise performance in mice.
American journal of physiology. Endocrinology and metabolism May, 2015 | Pubmed ID: 25783895
Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity.
Obesity (Silver Spring, Md.) May, 2015 | Pubmed ID: 25865747
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
Journal of leukocyte biology Nov, 2015 | Pubmed ID: 26109679
Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice.
Endocrinology Oct, 2015 | Pubmed ID: 26196542
Adipose Tissue Lipolysis Promotes Exercise-induced Cardiac Hypertrophy Involving the Lipokine C16:1n7-Palmitoleate.
The Journal of biological chemistry Sep, 2015 | Pubmed ID: 26260790
Manganese [III] Tetrakis [5,10,15,20]-Benzoic Acid Porphyrin Reduces Adiposity and Improves Insulin Action in Mice with Pre-Existing Obesity.
PloS one , 2015 | Pubmed ID: 26397111
Three-Dimensional Adipocyte Culture: The Next Frontier for Adipocyte Biology Discovery.
Endocrinology Dec, 2015 | Pubmed ID: 26492473
Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.
Obesity (Silver Spring, Md.) Dec, 2015 | Pubmed ID: 26727116
Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes.
Oncotarget May, 2016 | Pubmed ID: 27105497
A thrifty variant in CREBRF strongly influences body mass index in Samoans.
Nature genetics Sep, 2016 | Pubmed ID: 27455349
Liver X receptor mediates hepatic triglyceride accumulation through upregulation of G0/G1 Switch Gene 2 expression.
JCI insight Feb, 2017 | Pubmed ID: 28239648
Autotaxin Is Regulated by Glucose and Insulin in Adipocytes.
Endocrinology Apr, 2017 | Pubmed ID: 28324037
Kidney triglyceride accumulation in the fasted mouse is dependent upon serum free fatty acids.
Journal of lipid research Jun, 2017 | Pubmed ID: 28404638
Differential Impact of Weight Loss on Nonalcoholic Fatty Liver Resolution in a North American Cohort with Obesity.
Obesity (Silver Spring, Md.) Aug, 2017 | Pubmed ID: 28605159
Fatty acid oxidation by the osteoblast is required for normal bone acquisition in a sex- and diet-dependent manner.
JCI insight Aug, 2017 | Pubmed ID: 28814665
Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events .
G3 (Bethesda, Md.) Oct, 2017 | Pubmed ID: 28860183
Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.
Cell metabolism Sep, 2017 | Pubmed ID: 28877455
Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.
Cell metabolism Nov, 2017 | Pubmed ID: 28988821
Adipose tissue ATGL modifies the cardiac lipidome in pressure-overload-induced left ventricular failure.
PLoS genetics Jan, 2018 | Pubmed ID: 29320510
Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation.
Journal of lipid research May, 2018 | Pubmed ID: 29599420
Jak-TGFβ cross-talk links transient adipose tissue inflammation to beige adipogenesis.
Science signaling Apr, 2018 | Pubmed ID: 29692363
Atglistatin ameliorates functional decline in heart failure via adipocyte-specific inhibition of adipose triglyceride lipase.
American journal of physiology. Heart and circulatory physiology Oct, 2018 | Pubmed ID: 29932770
Adipose tissue-derived free fatty acids initiate myeloid cell accumulation in mouse liver in states of lipid oversupply.
American journal of physiology. Endocrinology and metabolism Nov, 2018 | Pubmed ID: 30086648
Wnt Pathway Inhibitor DKK1: A Potential Novel Biomarker for Adiposity.
Journal of the Endocrine Society Feb, 2019 | Pubmed ID: 30746507
Symptoms and Dietary Impact in Hypertriglyceridemia-Associated Pancreatitis: Development and Content Validity of Two New Measures.
PharmacoEconomics - open Mar, 2020 | Pubmed ID: 31250380
Impact of Hepatic Steatosis on Resting Metabolic Rate and Metabolic Adaptation in Response to Intentional Weight Loss.
Hepatology communications Oct, 2019 | Pubmed ID: 31592493
Adipose Tissue Quality in Aging: How Structural and Functional Aspects of Adipose Tissue Impact Skeletal Muscle Quality.
Nutrients Oct, 2019 | Pubmed ID: 31652734
The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women.
PloS one , 2019 | Pubmed ID: 31770380
Decreased Mitochondrial Dynamics Is Associated with Insulin Resistance, Metabolic Rate, and Fitness in African Americans.
The Journal of clinical endocrinology and metabolism Apr, 2020 | Pubmed ID: 31833547
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation.
The Journal of clinical investigation Apr, 2020 | Pubmed ID: 31917686
Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observational Cohort Study.
JMIR research protocols Jul, 2020 | Pubmed ID: 32706746
Inhibition of ATGL in adipose tissue ameliorates isoproterenol-induced cardiac remodeling by reducing adipose tissue inflammation.
American journal of physiology. Heart and circulatory physiology Jan, 2021 | Pubmed ID: 33185110
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
Communications biology Mar, 2021 | Pubmed ID: 33692445
Quantifying the progression of non-alcoholic fatty liver disease in human biomimetic liver microphysiology systems with fluorescent protein biosensors.
Experimental biology and medicine (Maywood, N.J.) Nov, 2021 | Pubmed ID: 33957803
Pharmacological inhibition of adipose tissue adipose triglyceride lipase by Atglistatin prevents catecholamine-induced myocardial damage.
Cardiovascular research Aug, 2022 | Pubmed ID: 34061169
C-reactive protein in adult Samoans: Population variation and physiological correlates.
American journal of human biology : the official journal of the Human Biology Council Mar, 2022 | Pubmed ID: 34260111
Body size and composition of Samoan toddlers aged 18-25 months in 2019.
Annals of human biology Jun, 2021 | Pubmed ID: 34340601
A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.
PloS one , 2021 | Pubmed ID: 34520472
Mechanistic studies of PEG-asparaginase-induced liver injury and hepatic steatosis in mice.
Acta pharmaceutica Sinica. B Dec, 2021 | Pubmed ID: 35024306
Effect of physical activity in a weight loss program on circulating total ANGPTL8 concentrations in northern Americans with obesity: A prospective randomized controlled trial.
Nutrition, metabolism, and cardiovascular diseases : NMCD Jul, 2022 | Pubmed ID: 35527126
The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans.
Obesity (Silver Spring, Md.) Dec, 2022 | Pubmed ID: 36284436
A stop-gain variant in is associated with atherogenic lipid profiles.
HGG advances Jan, 2023 | Pubmed ID: 36340932
Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries.
Genetic epidemiology Feb, 2023 | Pubmed ID: 36352773
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial.
Nature medicine Mar, 2023 | Pubmed ID: 36879129
Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues.
bioRxiv : the preprint server for biology Oct, 2023 | Pubmed ID: 37214953
Medical management of hypertriglyceridemia in pancreatitis.
Current opinion in gastroenterology Sep, 2023 | Pubmed ID: 37421386
Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome.
Journal of lipid research Feb, 2024 | Pubmed ID: 37640283
Association between age at menarche and cardiometabolic risk among Samoan adults.
American journal of human biology : the official journal of the Human Biology Council Jan, 2024 | Pubmed ID: 37668413
Percutaneous biopsies of skeletal muscle and adipose tissue in individuals older than 70: methods and outcomes in the Study of Muscle, Mobility and Aging (SOMMA).
GeroScience Jun, 2024 | Pubmed ID: 38315316
Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes.
Diabetes Mar, 2024 | Pubmed ID: 38551899
Line O. Elingaard-Larsen1,2,
Katie L. Whytock1,
Adeline Divoux1,
Meghan Hopf1,
Erin E. Kershaw3,
Jamie N. Justice4,
Bret H. Goodpaster1,
Nancy E. Lane5,
Lauren M. Sparks1
1Translational Research Institute, AdventHealth,
2, Steno Diabetes Center Copenhagen,
3Division of Endocrinology and Metabolism, University of Pittsburgh,
4Gerontology and Geriatric Medicine, Wake Forest University School of Medicine,
5Department of Internal Medicine - Rheumatology, Allergy, and Clinical Immunology, University of California Davis Health