School of Physiology,
Pharmacology and Neuroscience,
Biomedical Science Building,
School of Physiology, Pharmacology and Neuroscience, Biomedical Science Building
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Using transgenic reporters to visualize bone and cartilage signaling during development in vivo.
Frontiers in endocrinology , 2012 | Pubmed ID: 22826703
Expression of glycosaminoglycan epitopes during zebrafish skeletogenesis.
Developmental dynamics : an official publication of the American Association of Anatomists Jun, 2013 | Pubmed ID: 23576310
Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis.
PloS one , 2013 | Pubmed ID: 24086633
Glucocerebrosidase deficiency in zebrafish affects primary bone ossification through increased oxidative stress and reduced Wnt/β-catenin signaling.
Human molecular genetics Mar, 2015 | Pubmed ID: 25326392
Finite element modelling predicts changes in joint shape and cell behaviour due to loss of muscle strain in jaw development.
Journal of biomechanics Sep, 2015 | Pubmed ID: 26253758
Differential effects of altered patterns of movement and strain on joint cell behaviour and skeletal morphogenesis.
Osteoarthritis and cartilage Nov, 2016 | Pubmed ID: 27374878
The Golgi matrix protein giantin is required for normal cilia function in zebrafish.
Biology open Aug, 2017 | Pubmed ID: 28546340
Wnt signalling controls the response to mechanical loading during zebrafish joint development.
Development (Cambridge, England) Aug, 2017 | Pubmed ID: 28684625
Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.
Journal of cell science Dec, 2017 | Pubmed ID: 29093022
Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.
Journal of cell science May, 2018 | Pubmed ID: 29643119
The mechanical impact of loss on joints; mutant zebrafish show changes to joint development and function, which leads to early-onset osteoarthritis.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences Sep, 2018 | Pubmed ID: 30249781
Zebrafish as an Emerging Model for Osteoporosis: A Primary Testing Platform for Screening New Osteo-Active Compounds.
Frontiers in endocrinology , 2019 | Pubmed ID: 30761080
Scleraxis genes are required for normal musculoskeletal development and for rib growth and mineralization in zebrafish.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 08, 2019 | Pubmed ID: 31100023
A Rare Mutation in SMAD9 Associated With High Bone Mass Identifies the SMAD-Dependent BMP Signaling Pathway as a Potential Anabolic Target for Osteoporosis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Jan, 2020 | Pubmed ID: 31525280
Finite element and deformation analyses predict pattern of bone failure in loaded zebrafish spines.
Journal of the Royal Society, Interface Nov, 2019 | Pubmed ID: 31690186
Zebrafish as a model to study autophagy and its role in skeletal development and disease.
Histochemistry and cell biology Nov, 2020 | Pubmed ID: 32915267
Potential of zebrafish as a model to characterise MicroRNA profiles in mechanically mediated joint degeneration.
Histochemistry and cell biology Nov, 2020 | Pubmed ID: 32935147
Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis.
Aging Sep, 2020 | Pubmed ID: 32979261
NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss.
Human molecular genetics Jan, 2021 | Pubmed ID: 33326993
Skeletal Biology and Disease Modeling in Zebrafish.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Mar, 2021 | Pubmed ID: 33484578
Exposure to hypergravity during zebrafish development alters cartilage material properties and strain distribution.
Bone & joint research Feb, 2021 | Pubmed ID: 33560137
Transformed notochordal cells trigger chronic wounds in zebrafish, destabilizing the vertebral column and bone homeostasis.
Disease models & mechanisms Mar, 2021 | Pubmed ID: 33579726
Opportunities and Challenges in Functional Genomics Research in Osteoporosis: Report From a Workshop Held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020.
Frontiers in endocrinology , 2020 | Pubmed ID: 33658983
Pharmacological Manipulation of Early Zebrafish Skeletal Development Shows an Important Role for Smad9 in Control of Skeletal Progenitor Populations.
Biomolecules Feb, 2021 | Pubmed ID: 33668680
Wnt16 Elicits a Protective Effect Against Fractures and Supports Bone Repair in Zebrafish.
JBMR plus Mar, 2021 | Pubmed ID: 33778326
Giantin is required for intracellular N-terminal processing of type I procollagen.
The Journal of cell biology Jun, 2021 | Pubmed ID: 33944912
3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease.
Bone research Aug, 2021 | Pubmed ID: 34465741
Autophagy coordinates chondrocyte development and early joint formation in zebrafish.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Nov, 2021 | Pubmed ID: 34708458
Corrigendum to: NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss.
Human molecular genetics Dec, 2021 | Pubmed ID: 34788418
Dominating lengthscales of zebrafish collective behaviour.
PLoS computational biology Jan, 2022 | Pubmed ID: 35025883
Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease.
BMC biology Jan, 2022 | Pubmed ID: 35057801
Growth orientations, rather than heterogeneous growth rates, dominate jaw joint morphogenesis in the larval zebrafish.
Journal of anatomy Aug, 2022 | Pubmed ID: 35510779
Osteomodulin downregulation is associated with osteoarthritis development.
Bone research Sep, 2023 | Pubmed ID: 37730805
Compressive stress gradients direct mechanoregulation of anisotropic growth in the zebrafish jaw joint.
PLoS computational biology Feb, 2024 | Pubmed ID: 38330044