S'identifier

Frederic St-Denis-Bissonnette

Biologic and Radiopharmaceutical Drugs Directorate

BIOGRAPHY

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PUBLICATIONS

Hollow-fiber bioreactor production of extracellular vesicles from human bone marrow mesenchymal stromal cells yields nanovesicles that mirrors the immuno-modulatory antigenic signature of the producer cell.

Stem cell research & therapy Feb, 2021 | Pubmed ID: 33579358

Applications of Extracellular Vesicles in Triple-Negative Breast Cancer.

Cancers Jan, 2022 | Pubmed ID: 35053616

A clinically relevant large-scale biomanufacturing workflow to produce natural killer cells and natural killer cell-derived extracellular vesicles for cancer immunotherapy.

Journal of extracellular vesicles Dec, 2023 | Pubmed ID: 38054534

SARS-CoV-2 antigen-carrying extracellular vesicles activate T cell responses in a human immunogenicity model.

iScience Jan, 2024 | Pubmed ID: 38226155

Evaluation of resazurin phenoxazine dye as a highly sensitive cell viability potency assay for natural killer cell-derived extracellular vesicle-based cancer biotherapeutics.

Journal of extracellular biology Jul, 2024 | Pubmed ID: 39022723

INSTITUTIONS

Biologic and Radiopharmaceutical Drugs Directorate

University of Ottawa

JOVE ARTICLES

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Frederic St-Denis-Bissonnette^*,1,2,

Melanie Kirkby^*,1,2,

Lisheng Wang^2,3,4,

Jessie R. Lavoie^1,2

¹, Biologic and Radiopharmaceutical Drugs Directorate,

²Department of Biochemistry, Microbiology and Immunology Institute, University of Ottawa,

³Centre for Infection, Immunity and Inflammation Institute, University of Ottawa,

⁴Regenerative Medicine Program, Ottawa Hospital Research Institute

Cancer Research

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