Caius G. Radu

Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner.

T cell chemotaxis to lysophosphatidylcholine through the G2A receptor.

Gi-independent macrophage chemotaxis to lysophosphatidylcholine via the immunoregulatory GPCR G2A.

Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells.

Lysophosphatidylcholine-induced surface redistribution regulates signaling of the murine G protein-coupled receptor G2A.

Visualization of a primary anti-tumor immune response by positron emission tomography.

Normal immune development and glucocorticoid-induced thymocyte apoptosis in mice deficient for the T-cell death-associated gene 8 receptor.

Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor.

DNA-encoded antibody libraries: a unified platform for multiplexed cell sorting and detection of genes and proteins.

Positron emission tomography with computed tomography imaging of neuroinflammation in experimental autoimmune encephalomyelitis.

Requirements for T lymphocyte migration in explanted lymph nodes.

Sustained suppression of Bcr-Abl-driven lymphoid leukemia by microRNA mimics.

Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A.

Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain.

Non-invasive imaging of adaptive immunity using positron emission tomography.

PET imaging of cancer immunotherapy.

Molecular imaging of lymphoid organs and immune activation by positron emission tomography with a new [18F]-labeled 2'-deoxycytidine analog.

Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen.

Integrated microfluidic devices for combinatorial cell-based assays.

Noninvasive prediction of tumor responses to gemcitabine using positron emission tomography.

A supramolecular approach for preparation of size-controlled nanoparticles.

Modular nucleic acid assembled p/MHC microarrays for multiplexed sorting of antigen-specific T cells.

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.

Visualizing cancer and immune cell function with metabolic positron emission tomography.

AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas.

Requirement for deoxycytidine kinase in T and B lymphocyte development.

Targeting leukemia stem cells.

PET probes for distinct metabolic pathways have different cell specificities during immune responses in mice.

Imaging adoptive cell transfer based cancer immunotherapy.

Novel PET probes specific for deoxycytidine kinase.

Kinetic phases of distribution and tumor targeting by T cell receptor engineered lymphocytes inducing robust antitumor responses.

Human biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathway.

Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors.

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells.

Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.

Antitumor activity from antigen-specific CD8 T cells generated in vivo from genetically engineered human hematopoietic stem cells.

Stratification of nucleoside analog chemotherapy using 1-(2'-deoxy-2'-18F-fluoro-β-D-arabinofuranosyl)cytosine and 1-(2'-deoxy-2'-18F-fluoro-β-L-arabinofuranosyl)-5-methylcytosine PET.

Positron emission tomography reporter genes and reporter probes: gene and cell therapy applications.

In vivo imaging of therapy-induced anti-cancer immune responses in humans.

Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.