introductory-analysis-and-validation-of-cut-run-sequencing-data

Introductory Analysis and Validation of CUT&#38;RUN Sequencing Data

The CUT&amp;RUN technique facilitates detection of protein-DNA interactions across the genome. Typical applications of CUT&amp;RUN include profiling ...

University of Texas MD Anderson Cancer Center

Subsets of long interspersed nuclear element 1 (LINE-1) retrotransposons can 'retrotranspose' throughout the human genome at a cost to host cell fitness, as observed in some cancers. Pharmacological inhibition of LINE-1 retrotransposition requires a comprehensive understanding of the LINE-1 ORF2p reverse transcriptase. Two recent publications, by Thawani et al. and Baldwin et al., report structures of LINE-1 ORF2p and address long-standing mechanistic gaps regarding LINE-1 retrotransposition. Both studies will be critical to design new specific inhibitors of the LINE-1 ORF2p reverse transcriptase.

Nakyung Oh

Department of Epigenetics and Molecular Carcinogenesis

University of Texas MD Anderson Cancer Center

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Nakyung Oh

.css-o250i3{font-size:18px;font-family:Open Sans,sans-serif;line-height:21.6px;}Department of Epigenetics and Molecular Carcinogenesis

University of Texas MD Anderson Cancer Center

Introductory Analysis and Validation of CUT&RUN Sequencing Data

Department of Epigenetics and Molecular Carcinogenesis