Roland Brosch

Royal Society of Tropical Medicine and Hygiene Meeting at Manson House, London, 18th January 2001. Pathogen genomes and human health. Mycobacterial genomics.

Rapid and simple approach for identification of Mycobacterium tuberculosis complex isolates by PCR-based genomic deletion analysis.

Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant.

Loss of RD1 contributed to the attenuation of the live tuberculosis vaccines Mycobacterium bovis BCG and Mycobacterium microti.

Is Mycobacterium africanum subtype II (Uganda I and Uganda II) a genetically well-defined subspecies of the Mycobacterium tuberculosis complex?

Recombinant BCG exporting ESAT-6 confers enhanced protection against tuberculosis.

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of Mycobacterium ulcerans.

Genotypic analysis of Mycobacterium tuberculosis in Bangladesh and prevalence of the Beijing strain.

Macro-array and bioinformatic analyses reveal mycobacterial 'core' genes, variation in the ESAT-6 gene family and new phylogenetic markers for the Mycobacterium tuberculosis complex.

Cell envelope protein PPE68 contributes to Mycobacterium tuberculosis RD1 immunogenicity independently of a 10-kilodalton culture filtrate protein and ESAT-6.

Enhanced protection against tuberculosis by vaccination with recombinant Mycobacterium microti vaccine that induces T cell immunity against region of difference 1 antigens.

ESAT-6 proteins: protective antigens and virulence factors?

Common evolutionary origin for the unstable virulence plasmid pMUM found in geographically diverse strains of Mycobacterium ulcerans.

Influence of ESAT-6 secretion system 1 (RD1) of Mycobacterium tuberculosis on the interaction between mycobacteria and the host immune system.

Structure and mechanism of the alkyl hydroperoxidase AhpC, a key element of the Mycobacterium tuberculosis defense system against oxidative stress.

Modulation of the host immune response by a transient intracellular stage of Mycobacterium ulcerans: the contribution of endogenous mycolactone toxin.

Functional analysis of early secreted antigenic target-6, the dominant T-cell antigen of Mycobacterium tuberculosis, reveals key residues involved in secretion, complex formation, virulence, and immunogenicity.

Tuberculosis: from genome to vaccine.

Ancient origin and gene mosaicism of the progenitor of Mycobacterium tuberculosis.

Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on immunogenicity and virulence.

Horizontal transfer of a virulence operon to the ancestor of Mycobacterium tuberculosis.

"A re-evaluation of M. prototuberculosis": continuing the debate.

Genome plasticity of BCG and impact on vaccine efficacy.

ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity.

Cutting-edge science and the future of tuberculosis control.

Control of M. tuberculosis ESAT-6 secretion and specific T cell recognition by PhoP.

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis.

Functional analysis of a clonal deletion in an epidemic strain of Mycobacterium bovis reveals a role in lipid metabolism.

ESX/type VII secretion systems and their role in host-pathogen interaction.

Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants.

Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis.

Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosis.

Non mycobacterial virulence genes in the genome of the emerging pathogen Mycobacterium abscessus.

Mycobacterial PE, PPE and ESX clusters: novel insights into the secretion of these most unusual protein families.

[A promising new class of antituberculous molecules].

Systematic genetic nomenclature for type VII secretion systems.

High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors.

High content phenotypic cell-based visual screen identifies Mycobacterium tuberculosis acyltrehalose-containing glycolipids involved in phagosome remodeling.

Synthesis, biological activity, and evaluation of the mode of action of novel antitubercular benzofurobenzopyrans substituted on A ring.

Entrapment of intracytosolic bacteria by septin cage-like structures.

Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants.

ESAT-6 secretion-independent impact of ESX-1 genes espF and espG1 on virulence of Mycobacterium tuberculosis.

Deciphering the role of IS6110 in a highly transmissible Mycobacterium tuberculosis Beijing strain, GC1237.

p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways.

Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis.

Phagosomal rupture by Mycobacterium tuberculosis results in toxicity and host cell death.

Disruption of the ESX-5 system of Mycobacterium tuberculosis causes loss of PPE protein secretion, reduction of cell wall integrity and strong attenuation.

Characterization of Mycobacterium orygis as M. tuberculosis complex subspecies.

Strong immunogenicity and cross-reactivity of Mycobacterium tuberculosis ESX-5 type VII secretion: encoded PE-PPE proteins predicts vaccine potential.

ESX-1-mediated translocation to the cytosol controls virulence of mycobacteria.

Multidrug-resistant tuberculosis in admitted patients at a tertiary referral hospital of Bangladesh.

ESX-1 dependent impairment of autophagic flux by Mycobacterium tuberculosis in human dendritic cells.

The ESX-5 associated eccB-EccC locus is essential for Mycobacterium tuberculosis viability.

Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis.

TBCAP; tuberculosis annotation project.