Joseph M. Wider

Comparison of the NMR solution structure with the X-ray crystal structure of the activation domain from procarboxypeptidase B.

Pancreatic procarboxypeptidases: their activation processes related to the structural features of the zymogens and activation segments.

NMR determination of residual structure in a urea-denatured protein, the 434-repressor.

Cyclosporin A-cyclophilin complex formation. A model based on X-ray and NMR data.

Complete 15N and 1H NMR assignments for the amino-terminal domain of the phage 434 repressor in the urea-unfolded form.

1H, 15N and 13C NMR assignments of the 434 repressor fragments 1-63 and 44-63 unfolded in 7 M urea.

The effect of fibrin glue on skin grafts in infected sites.

Protein secondary structure determination by NMR. Application with recombinant human cyclophilin.

Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy.

Skin closure with dye-enhanced laser welding and fibrinogen.

Receptor-induced conformation change of the immunosuppressant cyclosporin A.

The NMR structure of the activation domain isolated from porcine procarboxypeptidase B.

The NMR structure of cyclosporin A bound to cyclophilin in aqueous solution.

Sequence-specific 1H NMR assignments and determination of the secondary structure for the activation domain isolated from pancreatic procarboxypeptidase B.

The complete amino acid sequence of porcine gastrotropin, an ileal protein which stimulates gastric acid and pepsinogen secretion.

Isolation and partial characterization of gastrotropin from canine ileum: further studies of the parietal and chief cell response.

Salt-stabilized globular protein structure in 7 M aqueous urea solution.

Frey's syndrome: prevention with temporoparietal fascial flap interposition.

Interaction of urea with an unfolded protein. The DNA-binding domain of the 434-repressor.

Internal brain herniation in a patient with Apert's syndrome.

Determination of the NMR solution structure of the cyclophilin A-cyclosporin A complex.

3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.

The inhibition of fibroblast-populated collagen lattice contraction by human amniotic fluid: a chronologic examination.

Generation of antigen-presenting cells for soluble protein antigens ex vivo from peripheral blood CD34+ hematopoietic progenitor cells in cancer patients.

NMR structure of the mouse prion protein domain PrP(121-231).

Prevention of splashing during high-pressure irrigation of contaminated wounds.

Monitoring NMR spectrometer performance during data accumulation for macromolecular structure determination.

The use of the labiocolumellar crease incision in rhinoplasty.

Simultaneous osseous genioplasty and meloplasty.

The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor.

Prion protein NMR structure and species barrier for prion diseases.

Three-dimensional NMR structure of a self-folding domain of the prion protein PrP(121-231)

Recombinant full-length murine prion protein, mPrP(23-231): purification and spectroscopic characterization.

NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).

Biomphalaria glabrata: relevance of albino organisms as a useful tool for environmental lead monitoring.

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution.

Solvent magnetization artifacts in high-field NMR studies of macromolecular hydration.

Prion protein structural features indicate possible relations to signal peptidases.

[Changes in the levels of delta-aminolevulinic acid dehydratase in chronic alcoholic patients].

Prion protein NMR structure and familial human spongiform encephalopathies.

TROSY in triple-resonance experiments: new perspectives for sequential NMR assignment of large proteins.

Dialogue. Industry consolidation: what's at stake for consumers and purchasers?

Polarization transfer by cross-correlated relaxation in solution NMR with very large molecules.

Photostimulable storage phosphor image acquisition: evaluation of three commercially available state-of-the-art systems.

[13C]-constant-time [15N,1H]-TROSY-HNCA for sequential assignments of large proteins.

NMR structure of the sea urchin (Strongylocentrotus purpuratus) metallothionein MTA.

The 3D NOESY-[(1)H,(15)N,(1)H]-ZQ-TROSY NMR experiment with diagonal peak suppression.

NMR spectroscopy of large molecules and multimolecular assemblies in solution.

Improved sensitivity and coherence selection for [15N,1H]-TROSY elements in triple resonance experiments.

NMR solution structure of the human prion protein.

Sensitivity gain by simultaneous acquisition of two coherence pathways: the HNCA(+) experiment.

NMR experiments for resonance assignments of 13C, 15N doubly-labeled flexible polypeptides: application to the human prion protein hPrP(23-230).

UK medical charities and clinical trials.

Picture archiving and communication systems project management using web-based tools.

Planning factors for developing an enterprise-wide picture archiving and communication system maintenance program.

Unilateral mydriasis after nasal reconstruction surgery.

Structure determination of biological macromolecules in solution using nuclear magnetic resonance spectroscopy.

Atomically resolved images from near node photoelectron holography experiments on Al(111).

Enhanced in vitro induced production of interleukin 10 by peripheral blood mononuclear cells in rheumatoid arthritis is associated with clinical response to methotrexate treatment.

Size-dependent melting of self-assembled indium nanostructures.

Modeling pentachlorophenol bioavailability and bioaccumulation by the freshwater fingernail clam Sphaerium corneum using artificial particles and humic acids.

Evidence of differences in the biotransformation of organic contaminants in three species of freshwater invertebrates.

The frontonasal flap for increased exposure in posttraumatic nasal deformity: a technical overview.

[Acupuncture for back pain: meta-analysis of randomised controlled trials and an update with data from the most recent studies].

Lipid-protein interactions in DHPC micelles containing the integral membrane protein OmpX investigated by NMR spectroscopy.

Differential expression of inflammatory mediators in radiation-impaired wound healing.

Side chain NMR assignments in the membrane protein OmpX reconstituted in DHPC micelles.

Medical research charities should fund more trials.

Influence of particle characteristics and organic matter content on the bioavailability and bioaccumulation of pyrene by clams.

Stereospecific assignments of the isopropyl methyl groups of the membrane protein OmpX in DHPC micelles.

NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain.

Dissection of heteronuclear NMR experiments for studies of magnetization transfer efficiencies.

TROSY in NMR studies of the structure and function of large biological macromolecules.

CAM research funding in the UK: surveys of medical charities in 1999 and 2002.

NMR structure of the integral membrane protein OmpX.

Determination of the absolute chirality of adsorbed molecules.

Membrane protein-lipid interactions in mixed micelles studied by NMR spectroscopy with the use of paramagnetic reagents.

NMR structure of a variant 434 repressor DNA-binding domain devoid of hydroxyl groups.

Segmental dystonia induced by wearing glasses with a ribbon: an unusual case of a reverse sensory geste.

NMR structures of salt-refolded forms of the 434-repressor DNA-binding domain in 6 M urea.

Comparative study on two freshwater invertebrates for monitoring environmental lead exposure.

NMR techniques used with very large biological macromolecules in solution.

CAM research in Britain: the last 10 years.

Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures.

Automated projection spectroscopy (APSY).

Direct NMR observation of a substrate protein bound to the chaperonin GroEL.

Effective rotational correlation times of proteins from NMR relaxation interference.

Effects of 5-aza-2'-deoxycytidine on proliferation, differentiation and p15/INK4b regulation of human hematopoietic progenitor cells.

Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

NMR-derived dynamic aspects of N-type inactivation of a Kv channel suggest a transient interaction with the T1 domain.

Chiral recognition of organic molecules by atomic kinks on surfaces.

Measuring protein concentrations by NMR spectroscopy.

[Neuronal death and growth factors: new therapeutic approaches in Parkinson's disease].

Potential use of glycogen level as biomarker of chemical stress in Biomphalaria glabrata.

Automated resonance assignment of proteins: 6D APSY-NMR.

Bilateral compressive lumbosacral plexopathy due to internal iliac artery aneurysms.

Concentration measurements by PULCON using X-filtered or 2D NMR spectra.

Long-duration response to levodopa in patients with advanced Parkinson disease treated with subthalamic deep brain stimulation.

Painful hand and moving finger treated by wearing a glove.

Complementary therapies for back pain: is the evidence getting stronger?

Proton-proton Overhauser NMR spectroscopy with polypeptide chains in large structures.

Complementary/alternative medicine for supportive cancer care: development of the evidence-base.

Does starvation influence the antioxidant status of the digestive gland of Nacella concinna in experimental conditions?

Acupuncture: its evidence-base is changing.

Quantification of tremor and bradykinesia in Parkinson's disease using a novel ambulatory monitoring system.

Real-time imaging of the spatial distribution of rf-heating in NMR samples during broadband decoupling.

The antioxidant vitamins A, C, E and selenium in the treatment of arthritis: a systematic review of randomized clinical trials.

Sequence-specific resonance assignment of soluble nonglobular proteins by 7D APSY-NMR spectroscopy.

Study of a Swiss dopa-responsive dystonia family with a deletion in GCH1: redefining DYT14 as DYT5.

Long-term outcome of 50 consecutive Parkinson's disease patients treated with subthalamic deep brain stimulation.

Rapidly progressive familial parkinsonism with central hypoventilation, depression and weight loss (Perry syndrome)--a literature review.

Structure-function analysis of the endoplasmic reticulum oxidoreductase TMX3 reveals interdomain stabilization of the N-terminal redox-active domain.

Characterization of in vitro growth of multiple myeloma cells.

Mind-body therapies: are the trial data getting stronger?

Interactions with hydrophobic clusters in the urea-unfolded membrane protein OmpX.

Program strategies for adolescent smoking cessation.

Projected [(1)H, (15)N]-HMQC-[ (1)H, (1)H]-NOESY for large molecular systems: application to a 121 kDa protein-DNA complex.

Clinical genetics of Parkinson's disease and related disorders.

Etiology and pathophysiology of frontotemporal dementia, Parkinson disease and Alzheimer disease: lessons from genetic studies.

Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family.

Progranulin gene mutation with an unusual clinical and neuropathologic presentation.

Automated NMR assignment of protein side chain resonances using automated projection spectroscopy (APSY).

Pallidonigral TDP-43 pathology in Perry syndrome.

Insights into the dynamics of hereditary diffuse leukoencephalopathy with axonal spheroids.

APSY-NMR with proteins: practical aspects and backbone assignment.

Movement disorders: insights into mechanisms and hopes for treatment.

Effect of cadmium, lead and arsenic on the oviposition, hatching and embryonic survival of Biomphalaria glabrata.

FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.

DCTN1 mutations in Perry syndrome.

Familial idiopathic basal ganglia calcification: a challenging clinical-pathological correlation.

The complementation of yeast with human or Plasmodium falciparum Hsp90 confers differential inhibitor sensitivities.

[Alternative diagnostic methods].

Phactr2 and Parkinson's disease.

GRN 3'UTR+78 C>T is not associated with risk for Parkinson's disease.

Leukoencephalopathy with spheroids (HDLS) and pigmentary leukodystrophy (POLD): a single entity?

Characterization of DCTN1 genetic variability in neurodegeneration.

GCH1 expression in human cerebellum from healthy individuals is not gender dependent.

Serenoa repens (saw palmetto): a systematic review of adverse events.

1H, 15N, 13C resonance assignment of the acyl carrier protein subunit of the Saccharomyces cerevisiae fatty acid synthase.

Calbindin-1 association and Parkinson's disease.

Coping strategies help women facing economic stress.

LINGO1 rs9652490 is associated with essential tremor and Parkinson disease.

A comparative study of LRRK2, PINK1 and genetically undefined familial Parkinson's disease.

Elucidating the genetics and pathology of Perry syndrome.

GCH1 in early-onset Parkinson's disease.

Artichoke leaf extract for treating hypercholesterolaemia.

Association of the MAPT locus with Parkinson's disease.

Conducting systematic reviews of complementary and alternative medicine: common pitfalls.

Glucocerebrosidase mutations are not a common risk factor for Parkinson disease in North Africa.

Depression in Parkinson's disease.

Clinical implications of gene discovery in Parkinson's disease and parkinsonism.

Leucine-rich repeat kinase 2 gene-associated disease: redefining genotype-phenotype correlation.

LINGO1 and LINGO2 variants are associated with essential tremor and Parkinson disease.

Association of pyridoxal kinase and Parkinson disease.

Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners.

Genetics of Parkinson disease and essential tremor.

Establishing partnerships to recruit and retain critical care nurses.

Monitoring bortezomib therapy in multiple myeloma: screening of cyclin D1, D2, and D3 via reliable real-time polymerase chain reaction and association with clinico-pathological features and outcome.

Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease.

Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body disease.

Complementary and alternative medicine use in England: results from a national survey.

Comprehensive sequencing of the LRRK2 gene in patients with familial Parkinson's disease from North Africa.

Food supplements for body weight reduction: a systematic review of systematic reviews.

Profound cardioprotection with chloramphenicol succinate in the swine model of myocardial ischemia-reperfusion injury.

Structural analysis of the conserved ubiquitin-binding motifs (UBMs) of the translesion polymerase iota in complex with ubiquitin.

Platelets and lipoproteins.

Single Transition-to-single Transition Polarization Transfer (ST2-PT) in [15N,1H]-TROSY.

SNCA, MAPT, and GSK3B in Parkinson disease: a gene-gene interaction study.

Cerebral and somatic venous oximetry in adults and infants.

Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter.

The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review and Meta-Analysis of Randomised Clinical Trials.

Successful heart and liver transplantation in a Swiss patient with Glu89Lys transthyretin amyloidosis.

Early and mature endothelial progenitors and VEGFR2+-cells in multiple myeloma: association with disease characteristics and variation in different cell compartments.

Near-infrared spectroscopy monitoring of cerebral oxygen during assisted ventilation.

Automated projection spectroscopy and its applications.

Death-associated protein kinase 1 variation and Parkinson's disease.

VPS35 mutations in Parkinson disease.

Dose-dependent hemodynamic and metabolic effects of vasoactive medications in normotensive, anesthetized neonatal piglets.

Structure, folding and stability of FimA, the main structural subunit of type 1 pili from uropathogenic Escherichia coli strains.

4D APSY-HBCB(CG)CDHD experiment for automated assignment of aromatic amino acid side chains in proteins.

Loss of ability to work and ability to live independently in Parkinson's disease.

Sugar-to-base correlation in nucleic acids with a 5D APSY-HCNCH or two 3D APSY-HCN experiments.

Genetics of essential tremor.

Overview of primary monogenic dystonia.

Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids.

When funds for professional development are scarce.

An evaluation of the impact of MAPT, SNCA and APOE on the burden of Alzheimer's and Lewy body pathology.

Quality of herbal medicines: challenges and solutions.

Identifying and responding to child abuse in the home.

Characterizing the mechanical parameters of forward and backward falls as experienced in snowboarding.

MRI characteristics and scoring in HDLS due to CSF1R gene mutations.

Automated projection spectroscopy (APSY) for the assignment of NMR resonances of biological macromolecules.

Effect of vagus nerve stimulation in an adult patient with Dravet syndrome: contribution to sudden unexpected death in epilepsy risk reduction?.

Potent in vitro and in vivo activity of sorafenib in multiple myeloma: induction of cell death, CD138-downregulation and inhibition of migration through actin depolymerization.

CSF1R mutations link POLD and HDLS as a single disease entity.

Artichoke leaf extract for treating hypercholesterolaemia.

Successful long-term bilateral subthalamic nucleus deep brain stimulation in VPS35 Parkinson's disease.

4D experiments measured with APSY for automated backbone resonance assignments of large proteins.

Combination Therapy With Insulin-like Growth Factor-1 and Hypothermia Synergistically Improves Outcome After Transient Global Brain Ischemia in the Rat.