Mike D. Blower

Effects of various 5-HT3 receptor antagonists, granisetron, ondansetron, ramosetron and azasetron on serotonin (5-HT) release from the ferret isolated ileum.

A tale of two futures: HIV and antiretroviral therapy in San Francisco.

Low-doses of ionising radiation induce melanoma metastases and trigger the immune system--adrenal axis feedback loop.

No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study.

Impact of antivirals and emergence of drug resistance: HSV-2 epidemic control.

Potential impact of tuberculosis vaccines as epidemic control agents.

Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET.

Oral serotonin type 3-receptor antagonists for prevention of chemotherapy-induced emesis.

99mTc(V)DMSA quantitatively predicts 188Re(V)DMSA distribution in patients with prostate cancer metastatic to bone.

Failure to replicate association between the gene for the neuronal nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and IGE.

LeadScope: software for exploring large sets of screening data.

Trithiacyclononane as a ligand for potential technetium and rhenium radiopharmaceuticals: synthesis of [M(9S3)(SC2H4SC2H4S)][BF4] (M = 99Tc, Re, 188Re) via C-S bond cleavage.

Early therapy for latent tuberculosis infection.

Live attenuated HIV vaccines: predicting the tradeoff between efficacy and safety.

Association between the alpha(1a) calcium channel gene CACNA1A and idiopathic generalized epilepsy.

Leprosy research in the post-genome era.

Towards new transition metal-based hypoxic selective agents for therapy and imaging.

The continuing HIV epidemic among men who have sex with men.

Calculating the consequences: HAART and risky sex.

In vivo evaluation of 111In-DTPA-N-TIMP-2 in Kaposi sarcoma associated with HIV infection.

The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions.

Determining centromere identity: cyclical stories and forking paths.

Predicting the unpredictable: transmission of drug-resistant HIV.

Transmission of zidovudine resistant strains of HIV-1: the first wave.

Synthesis and characterization of 111In-DTPA-N-TIMP-2: a radiopharmaceutical for imaging matrix metalloproteinase expression.

Chem-tox informatics: data mining using a medicinal chemistry building block approach.

Amplification dynamics: predicting the effect of HIV on tuberculosis outbreaks.

Great expectations? Parental participation in care.

Conserved organization of centromeric chromatin in flies and humans.

Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals.

On combining recursive partitioning and simulated annealing to detect groups of biologically active compounds.

Copper bis(thiosemicarbazone) complexes as hypoxia imaging agents: structure-activity relationships.

A study comparing hyoscine hydrobromide and glycopyrrolate in the treatment of death rattle.

Multiscale and Bayesian approaches to data analysis in genomics high-throughput screening.

Granisetron vs ondansetron: is it a question of duration of 5-HT3 receptor blockade?

Problems and solutions for the Stop TB partnership.

Could widespread use of combination antiretroviral therapy eradicate HIV epidemics?

Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data.

5-HT3-receptor antagonists and the cytochrome P450 system: clinical implications.

Predicting the transmission of drug-resistant HIV: comparing theory with data.

Changes in muscle strength and pain in response to surgical repair of posterior abdominal wall disruption followed by rehabilitation.

99mTc-SnF2 colloid "LLK": particle size, morphology and leucocyte labelling behaviour.

Granisetron: relating pharmacology to clinical efficacy.

Predicting the emergence of drug-resistant HSV-2: new predictions.

Solid-phase synthesis of peptide radiopharmaceuticals using Fmoc-N-epsilon-(hynic-Boc)-lysine, a technetium-binding amino acid: application to Tc-99m-labeled salmon calcitonin.

What can modeling tell us about the threat of antiviral drug resistance?

Forecasting the future of HIV epidemics: the impact of antiretroviral therapies & imperfect vaccines.

Hypoxia-targeting copper bis(selenosemicarbazone) complexes: comparison with their sulfur analogues.

Finding discriminating structural features by reassembling common building blocks.

Acf1 confers unique activities to ACF/CHRAC and promotes the formation rather than disruption of chromatin in vivo.

Predicting the impact of antiretrovirals in resource-poor settings: preventing HIV infections whilst controlling drug resistance.

Modelling the genital herpes epidemic.

An attempt at a new analysis of the mortality caused by smallpox and of the advantages of inoculation to prevent it. 1766.

Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance.

Could disease-modifying HIV vaccines cause population-level perversity?

Targeting virological core groups: a new paradigm for controlling herpes simplex virus type 2 epidemics.

Calculating the contribution of herpes simplex virus type 2 epidemics to increasing HIV incidence: treatment implications.

Potential public health impact of new tuberculosis vaccines.

Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.

Changes in the use of Hormone Replacement Therapy in New Zealand following the publication of the Women's Health Initiative trial.

Microbicides: anti-HIV efficacy and ethics.

The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models.

Correlating gene expression with chemical scaffolds of cytotoxic agents: ellipticines as substrates and inhibitors of MDR1.

Investigation into 64Cu-labeled Bis(selenosemicarbazone) and Bis(thiosemicarbazone) complexes as hypoxia imaging agents.

Designing equitable antiretroviral allocation strategies in resource-constrained countries.

A queueing model for chronic recurrent conditions under panel observation.

Evaluating the potential impact of vaginal microbicides to reduce the risk of acquiring HIV in female sex workers.

Is there a pharmacological basis for differences in 5-HT3-receptor antagonist efficacy in refractory patients?

Predicting the potential individual- and population-level effects of imperfect herpes simplex virus type 2 vaccines.

A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly.

The reinfection threshold does not exist.

Drug-drug interactions in oncology: why are they important and can they be minimized?

5-hydroxytryptamine type-3 receptor antagonists for chemotherapy-induced and radiotherapy-induced nausea and emesis: can we safely reduce the dose of administered agents?

Grazing and vigilance by Soay sheep on Lundy island: influence of group size, terrain and the distribution of vegetation.

Allocating antiretrovirals in South Africa: using modeling to determine treatment equity.

Predicting the potential public health impact of disease-modifying HIV vaccines in South Africa: the problem of subtypes.

Water-soluble phosphines for direct labeling of peptides with technetium and rhenium: insights from electrospray mass spectrometry.

Expression of an anti-CD33 single-chain antibody by Pichia pastoris.

Modeling the potential public health impact of imperfect HIV vaccines.

Response to Foss et al., 'Care should be taken when promoting microbicide use among sex workers who are able to use condoms consistently'.

Linking population-level models with growing networks: a class of epidemic models.

Decision tree methods in pharmaceutical research.

Systematic analysis of large screening sets in drug discovery.

Comparison of methods for sequential screening of large compound sets.

Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochores.

Rational choices for allocating antiretrovirals in Africa: treatment equity, epidemiological efficiency, and feasibility.

Towards molecular imaging and treatment of disease with radionuclides: the role of inorganic chemistry.

Role of parametric resonance in virological failure during HIV treatment interruption therapy.

Views of child psychiatrists on physical contact with patients.

Drosophila CENP-A mutations cause a BubR1-dependent early mitotic delay without normal localization of kinetochore components.

Predicting the epidemiological impact of antiretroviral allocation strategies in KwaZulu-Natal: the effect of the urban-rural divide.

The emergence of HIV transmitted resistance in Botswana: "when will the WHO detection threshold be exceeded?".

Trifluoroacetyl-HYNIC peptides: synthesis and 99mTc radiolabeling.

Xenopus tropicalis egg extracts provide insight into scaling of the mitotic spindle.

Theory versus data: how to calculate R0?

Chemoinformatics analysis identifies cytotoxic compounds susceptible to chemoresistance mediated by glutathione and cystine/glutamate transport system xc-.

Nonlinear vibrational spectroscopic studies of the adsorption and speciation of nitric acid at the vapor/acid solution interface.

Narrative review: antiretroviral therapy to prevent the sexual transmission of HIV-1.

Chemogenomic analysis identifies geldanamycins as substrates and inhibitors of ABCB1.

Longitudinal study of herpes simplex virus type 2 infection using viral dynamic modelling.

Can influenza epidemics be prevented by voluntary vaccination?

MicroRNA expression profiles for the NCI-60 cancer cell panel.

How far will we need to go to reach HIV-infected people in rural South Africa?

Predicting the future of XDR tuberculosis.

Modelling an outbreak of an emerging pathogen.

Cystine-glutamate transporter SLC7A11 mediates resistance to geldanamycin but not to 17-(allylamino)-17-demethoxygeldanamycin.

Effectiveness and efficiency of imperfect therapeutic HSV-2 vaccines.

Mean-field analysis of an inductive reasoning game: application to influenza vaccination.

How do HYNIC-conjugated peptides bind technetium? Insights from LC-MS and stability studies.

Effects of atmospherically important solvated ions on organic acid adsorption at the surface of aqueous solutions.

Genome-wide analysis demonstrates conserved localization of messenger RNAs to mitotic microtubules.

MicroRNAs modulate the chemosensitivity of tumor cells.

Infectious syphilis in high-income settings in the 21st century.

A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions.

In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation.

The paradoxical effects of using antiretroviral-based microbicides to control HIV epidemics.

Is there any evidence that syphilis epidemics cycle?

Acceptability and repeatability of spirometry in children using updated ATS/ERS criteria.

Pharmacogenomics approach reveals MRP1 (ABCC1)-mediated resistance to geldanamycins.

GODIVA2: interactive visualization of environmental data on the Web.

Running climate models on grids using G-Rex.

The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.

99mTc-HYNIC-Gastrin Peptides: Assisted Coordination of 99mTc by Amino Acid Side Chains Results in Improved Performance Both In Vitro and In Vivo.

Technetium-binding in labelled HYNIC-peptide conjugates: role of coordinating amino acids.

Modeling influenza epidemics and pandemics: insights into the future of swine flu (H1N1).

Mutagenesis and functional characterization of the RNA and protein components of the toxIN abortive infection and toxin-antitoxin locus of Erwinia.

Comparison of (64)Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability.

Bifunctional bisphosphonate complexes for the diagnosis and therapy of bone metastases.

Systematic and single cell analysis of Xenopus Piwi-interacting RNAs and Xiwi.

Nuclear imaging of molecular processes in cancer.

Efficient site-specific radiolabeling of a modified C2A domain of synaptotagmin I with [99mTc(CO)3]+: a new radiopharmaceutical for imaging cell death.

Radiobiological effects of hypoxia-dependent uptake of 64Cu-ATSM: enhanced DNA damage and cytotoxicity in hypoxic cells.

Quantifying the treatment efficacy of reverse transcriptase inhibitors: new analyses of clinical data based on within-host modeling.

Pharmacogenomic approach reveals a role for the x(c)- cystine/glutamate antiporter in growth and celastrol resistance of glioma cell lines.

Are correctional facilities amplifying the epidemic of community-acquired methicillin-resistant Staphylococcus aureus?

A broadly conserved pathway generates 3'UTR-directed primary piRNAs.

Calculating the potential for within-flight transmission of influenza A (H1N1).

Evolutionary dynamics of complex networks of HIV drug-resistant strains: the case of San Francisco.

Should we try to eliminate HIV epidemics by using a 'Test and Treat' strategy?

Modeling the potential impact of rectal microbicides to reduce hiv transmission in bathhouses.

A major HIV risk factor for young men who have sex with men is sex with older partners.

A universal long-term flu vaccine may not prevent severe epidemics.

188Re(CO)3-dipicolylamine-alendronate: a new bisphosphonate conjugate for the radiotherapy of bone metastases.

Predicting the level of vaccine-induced cross-immunity necessary to eliminate HIV epidemics composed of multiple subtypes.

Synthesis and biological evaluation of [(18)F]tetrafluoroborate: a PET imaging agent for thyroid disease and reporter gene imaging of the sodium/iodide symporter.

HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis.

Costs of eliminating HIV in South Africa have been underestimated.

Assessing the impact of mass rape on the incidence of HIV in conflict-affected countries.

Evaluation of [18F]-tetrafluoroborate as a potential PET imaging agent for the human sodium/iodide symporter in a new colon carcinoma cell line, HCT116, expressing hNIS.

Synthesis of porous hollow silica nanostructures using hydroxyapatite nanoparticle templates.

SPECT/CT lymphoscintigraphy of heterotopic cardiac grafts reveals novel sites of lymphatic drainage and T cell priming.

A processed noncoding RNA regulates an altruistic bacterial antiviral system.

Balancing at survival's edge: the structure and adaptive benefits of prokaryotic toxin-antitoxin partners.

(⁹⁹m)Tc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging.

Synthesis and evaluation of analogues of HYNIC as bifunctional chelators for technetium.

Biocompatible inorganic nanoparticles for [18F]-fluoride binding with applications in PET imaging.

Quantification of the role of discordant couples in driving incidence of HIV in sub-Saharan Africa.

Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with positron emission tomography.

Could we – should we – calculate a risk exposure score for an HIV-negative individual in a serodiscordant couple?

Synthesis of 64Cu(II)-bis(dithiocarbamatebisphosphonate) and its conjugation with superparamagnetic iron oxide nanoparticles: in vivo evaluation as dual-modality PET-MRI agent.

Monitoring the systemic human memory B cell compartment of melanoma patients for anti-tumor IgG antibodies.

Harnessing engineered antibodies of the IgE class to combat malignancy: initial assessment of FcɛRI-mediated basophil activation by a tumour-specific IgE antibody to evaluate the risk of type I hypersensitivity.

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Efficient bifunctional gallium-68 chelators for positron emission tomography: tris(hydroxypyridinone) ligands.

Macrobicyclic cage amine ligands for copper radiopharmaceuticals: a single bivalent cage amine containing two Lys3-bombesin targeting peptides.

The importance of including dynamic social networks when modeling epidemics of airborne infections: does increasing complexity increase accuracy?

PET imaging of cardiac hypoxia: opportunities and challenges.

Radiochemical purity testing of 99mTc-labelled radiopharmaceuticals: how much is enough?

Human papillomavirus vaccination programs and human immunodeficiency virus epidemics.

A multiscale parallel computing architecture for automated segmentation of the brain connectome.

Functional analysis of the microtubule-interacting transcriptome.

Building PET research collaborations.

National Electrical Manufacturers Association NU-4 performance evaluation of the PET component of the NanoPET/CT preclinical PET/CT scanner.

Modeling the impact on the HIV epidemic of treating discordant couples with antiretrovirals to prevent transmission.

In vivo SPECT reporter gene imaging of regulatory T cells.

Recombinant IgE antibodies for passive immunotherapy of solid tumours: from concept towards clinical application.

Hypoxia imaging with PET: which tracers and why?

A promiscuous antitoxin of bacteriophage T4 ensures successful viral replication.

Modeling dynamic interactions between pre-exposure prophylaxis interventions & treatment programs: predicting HIV transmission & resistance.

Factors limiting the transmission of HIV mutations conferring drug resistance: fitness costs and genetic bottlenecks.

Identification and classification of bacterial Type III toxin-antitoxin systems encoded in chromosomal and plasmid genomes.

A review of the application of molecular genetics for fisheries management and conservation of sharks and rays.

What impact will reducing concurrency have on decreasing the incidence of HIV in heterosexual populations?

[Re(CO)(3)](+) labelling of a novel cysteine/hexahistidine tag: insights into binding mode by liquid chromatography-mass spectrometry.

Predicting effect of pre-exposure prophylaxis on HIV epidemics.

A feasibility analysis of implementing interventions for discordant couples in 14 African countries: implications for epidemic control.

Dithiocarbamate complexes as radiopharmaceuticals for medical imaging.

Universal access to HIV treatment versus universal 'test and treat': transmission, drug resistance & treatment costs.

p53-dependent radiobiological responses to internalised indium-111 in human cells.

Viral evasion of a bacterial suicide system by RNA-based molecular mimicry enables infectious altruism.

Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging.

Bisphosphonate-anchored PEGylation and radiolabeling of superparamagnetic iron oxide: long-circulating nanoparticles for in vivo multimodal (T1 MRI-SPECT) imaging.

An integrated view of data quality in Earth observation.

Selectivity and self-assembly in the control of a bacterial toxin by an antitoxic noncoding RNA pseudoknot.

Molecular insights into intracellular RNA localization.

Surface behavior of malonic acid adsorption at the air/water interface.

IgG4 subclass antibodies impair antitumor immunity in melanoma.

The complete mitochondrial genome of the dusky shark Carcharhinus obscurus.

Bacillus anthracis co-opts nitric oxide and host serum albumin for pathogenicity in hypoxic conditions.

Viral molecular mimicry circumvents abortive infection and suppresses bacterial suicide to make hosts permissive for replication.