Christopher C.W. Hughes

Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM.

B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis.

Endothelial cells stimulate T cell NFAT nuclear translocation in the presence of cyclosporin A: involvement of the wnt/glycogen synthase kinase-3 beta pathway.

Integration of the non-genomic and genomic actions of estrogen. Membrane-initiated signaling by steroid to transcription and cell biology.

Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression.

Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

VEGF(121) and VEGF(165) regulate blood vessel diameter through vascular endothelial growth factor receptor 2 in an in vitro angiogenesis model.

Of mice and not men: differences between mouse and human immunology.

Diffusion limits of an in vitro thick prevascularized tissue.

Cell-autonomous notch signaling regulates endothelial cell branching and proliferation during vascular tubulogenesis.

Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA.

Immunomodulatory drugs (IMiDs) increase the production of IL-2 from stimulated T cells by increasing PKC-theta activation and enhancing the DNA-binding activity of AP-1 but not NF-kappaB, OCT-1, or NF-AT.

HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes.

Wnt signaling induces matrix metalloproteinase expression and regulates T cell transmigration.

Mesenchymal stem cells enhance angiogenesis in mechanically viable prevascularized tissues via early matrix metalloproteinase upregulation.

The effect of matrix density on the regulation of 3-D capillary morphogenesis.

TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype.

Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis.

Endothelial-stromal interactions in angiogenesis.

An optimized three-dimensional in vitro model for the analysis of angiogenesis.

The anti-cancer drug lenalidomide inhibits angiogenesis and metastasis via multiple inhibitory effects on endothelial cell function in normoxic and hypoxic conditions.

Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature.

TNF induction of jagged-1 in endothelial cells is NFkappaB-dependent.

Rapid anastomosis of endothelial progenitor cell-derived vessels with host vasculature is promoted by a high density of cotransplanted fibroblasts.

Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2.

Estradiol stimulates capillary formation by human endothelial progenitor cells: role of estrogen receptor-{alpha}/{beta}, heme oxygenase 1, and tyrosine kinase.

The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation.

Mouse and human strategies identify PTPN14 as a modifier of angiogenesis and hereditary haemorrhagic telangiectasia.

Longitudinal in vivo imaging to assess blood flow and oxygenation in implantable engineered tissues.

BMP9 induces EphrinB2 expression in endothelial cells through an Alk1-BMPRII/ActRII-ID1/ID3-dependent pathway: implications for hereditary hemorrhagic telangiectasia type II.

Macrophages and angiogenesis: a role for Wnt signaling.

Full range physiological mass transport control in 3D tissue cultures.

Analysis of stromal cell secretomes reveals a critical role for stromal cell-derived hepatocyte growth factor and fibronectin in angiogenesis.

In vitro perfused human capillary networks.

A microfluidic platform for generating large-scale nearly identical human microphysiological vascularized tissue arrays.

Angiogenic sprouting is regulated by endothelial cell expression of Slug.

Implanted cell-dense prevascularized tissues develop functional vasculature that supports reoxygenation after thrombosis.

Interferon-induced transmembrane protein 1 regulates endothelial lumen formation during angiogenesis.

A three-dimensional in vitro model of tumor cell intravasation.

A role for partial endothelial-mesenchymal transitions in angiogenesis?