Dale W. Laird

Gap junctions assemble in the presence of cytoskeletal inhibitors, but enhanced assembly requires microtubules.

Multicolor and electron microscopic imaging of connexin trafficking.

Retroviral delivery of connexin genes to human breast tumor cells inhibits in vivo tumor growth by a mechanism that is independent of significant gap junctional intercellular communication.

Lysosomal and proteasomal degradation play distinct roles in the life cycle of Cx43 in gap junctional intercellular communication-deficient and -competent breast tumor cells.

Transport and function of cx26 mutants involved in skin and deafness disorders.

Connexin26 regulates the expression of angiogenesis-related genes in human breast tumor cells by both GJIC-dependent and -independent mechanisms.

Functional domain mapping and selective trans-dominant effects exhibited by Cx26 disease-causing mutations.

Selective assembly of connexin37 into heterocellular gap junctions at the oocyte/granulosa cell interface.

Beta3 integrins facilitate matrix interactions during transendothelial migration of PC3 prostate tumor cells.

Oculodentodigital dysplasia-causing connexin43 mutants are non-functional and exhibit dominant effects on wild-type connexin43.

Down-regulation of Cx43 by retroviral delivery of small interfering RNA promotes an aggressive breast cancer cell phenotype.

Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.

Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture.

A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.

Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration.

Life cycle of connexins in health and disease.

Rat epidermal keratinocytes as an organotypic model for examining the role of Cx43 and Cx26 in skin differentiation.

Functional characterization of oculodentodigital dysplasia-associated Cx43 mutants.

A histone deacetylation-dependent mechanism for transcriptional repression of the gap junction gene cx43 in prostate cancer cells.

Cx26 inhibits breast MDA-MB-435 cell tumorigenic properties by a gap junctional intercellular communication-independent mechanism.

Functional characterization of a GJA1 frameshift mutation causing oculodentodigital dysplasia and palmoplantar keratoderma.

Connexins act as tumor suppressors in three-dimensional mammary cell organoids by regulating differentiation and angiogenesis.

Differential potency of dominant negative connexin43 mutants in oculodentodigital dysplasia.

Differentiation of organotypic epidermis in the presence of skin disease-linked dominant-negative Cx26 mutants and knockdown Cx26.

Connexins and gap junctions in mammary gland development and breast cancer progression.

Connexin levels regulate keratinocyte differentiation in the epidermis.

Pannexin 1 and pannexin 3 are glycoproteins that exhibit many distinct characteristics from the connexin family of gap junction proteins.

Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease.

Caveolin-1 and -2 interact with connexin43 and regulate gap junctional intercellular communication in keratinocytes.

The protective effect of functional connexin43 channels on a human epithelial cell line exposed to oxidative stress.

ODDD-linked Cx43 mutants reduce endogenous Cx43 expression and function in osteoblasts and inhibit late stage differentiation.

Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression.

Decreased levels of connexin43 result in impaired development of the mammary gland in a mouse model of oculodentodigital dysplasia.

Diverse subcellular distribution profiles of pannexin 1 and pannexin 3.

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

Cx43 has distinct mobility within plasma-membrane domains, indicative of progressive formation of gap-junction plaques.

A dominant loss-of-function GJA1 (Cx43) mutant impairs parturition in the mouse.

Oogenesis defects in a mutant mouse model of oculodentodigital dysplasia.

Glycosylation regulates pannexin intermixing and cellular localization.

光学和生化解剖的缝隙连接蛋白和疾病链接连接蛋白突变体 3D 器官表皮。

The gap junction proteome and its relationship to disease.

Pannexin1 and pannexin3 delivery, cell surface dynamics, and cytoskeletal interactions.

Milk secretion and ejection are impaired in the mammary gland of mice harboring a Cx43 mutant while expression and localization of tight and adherens junction proteins remain unchanged.

Implications of pannexin 1 and pannexin 3 for keratinocyte differentiation.

The tumor-suppressive function of Connexin43 in keratinocytes is mediated in part via interaction with caveolin-1.

Implications and challenges of connexin connections to cancer.

The potency of the fs260 connexin43 mutant to impair keratinocyte differentiation is distinct from other disease-linked connexin43 mutants.

Hypoxia and reoxygenation-induced oxidant production increase in microvascular endothelial cells depends on connexin40.

Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis.

Ocular pathology relevant to glaucoma in a Gja1(Jrt/+) mouse model of human oculodentodigital dysplasia.

Human dermal fibroblasts derived from oculodentodigital dysplasia patients suggest that patients may have wound-healing defects.

Characterization of pannexin1 and pannexin3 and their regulation by androgens in the male reproductive tract of the adult rat.

Pannexin channels are not gap junction hemichannels.

Pannexin1 regulates α1-adrenergic receptor- mediated vasoconstriction.

Rho signaling regulates pannexin 1-mediated ATP release from airway epithelia.

Pathways regulating the trafficking and turnover of pannexin1 protein and the role of the C-terminal domain.

The G60S connexin43 mutant regulates hair growth and hair fiber morphology in a mouse model of human oculodentodigital dysplasia.

Pannexin 3 is a novel target for Runx2, expressed by osteoblasts and mature growth plate chondrocytes.

The effect of connexin43 on the level of vascular endothelial growth factor in human retinal pigment epithelial cells.

The biochemistry and function of pannexin channels.