Hermona Soreq

Runx1/AML1 in leukemia: disrupted association with diverse protein partners.

Alternative splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity.

Upregulation of neuronal nicotinic receptor subunits alpha4, beta2, and alpha7 in transgenic mice overexpressing human acetylcholinesterase.

Transcriptional regulation of erythropoiesis. Fine tuning of combinatorial multi-domain elements.

The stress-associated acetylcholinesterase variant AChE-R is expressed in human CD34(+) hematopoietic progenitors and its C-terminal peptide ARP promotes their proliferation.

Complex regulation of acetylcholinesterase gene expression in human brain tumors.

Defects in pre-mRNA processing as causes of and predisposition to diseases.

Chronic acetylcholinesterase overexpression induces multilevelled aberrations in mouse neuromuscular physiology.

Interaction of "readthrough" acetylcholinesterase with RACK1 and PKCbeta II correlates with intensified fear-induced conflict behavior.

The role of readthrough acetylcholinesterase in the pathophysiology of myasthenia gravis.

Ethics, public policy and behavioral genetics.

Pre-mRNA splicing modulations in senescence.

Endotoxin-induced changes in human working and declarative memory associate with cleavage of plasma "readthrough" acetylcholinesterase.

Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study.

Combinatorial complexity of 5' alternative acetylcholinesterase transcripts and protein products.

CREB regulates AChE-R-induced proliferation of human glioblastoma cells.

Organophosphate risk of leukemogenesis.

From brain to blood: alternative splicing evidence for the cholinergic basis of Mammalian stress responses.

Blood-cell-specific acetylcholinesterase splice variations under changing stimuli.

Excessive expression of acetylcholinesterase impairs glutamatergic synaptogenesis in hippocampal neurons.

Identifying subtle interrelated changes in functional gene categories using continuous measures of gene expression.

Tissue distribution of cholinesterases and anticholinesterases in native and transgenic tomato plants.

Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease.

Function of alternative splicing.

Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities.

Functional manipulations of acetylcholinesterase splice variants highlight alternative splicing contributions to murine neocortical development.

Acetylcholinesterase inhibitors reduce brain and blood interleukin-1beta production.

Chronic cholinergic imbalances promote brain diffusion and transport abnormalities.

Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice.

Cellular stress reactions as putative cholinergic links in Alzheimer's disease.

MicroRNA modulation of megakaryoblast fate involves cholinergic signaling.

Purification of transgenic plant-derived recombinant human acetylcholinesterase-R.

Hydrolytic and nonenzymatic functions of acetylcholinesterase comodulate hemopoietic stress responses.

Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis.

Characterizing pea acetylcholinesterase.

RACK1 has the nerve to act: structure meets function in the nervous system.

Virtues and woes of AChE alternative splicing in stress-related neuropathologies.

Modulated splicing-associated gene expression in P19 cells expressing distinct acetylcholinesterase splice variants.

ARP, the cleavable C-terminal peptide of "readthrough" acetylcholinesterase, promotes neuronal development and plasticity.

Butyrylcholinesterase attenuates amyloid fibril formation in vitro.

Termination and beyond: acetylcholinesterase as a modulator of synaptic transmission.

Gene-environment interactions in sporadic Parkinson's disease.

Coding region paraoxonase polymorphisms dictate accentuated neuronal reactions in chronic, sub-threshold pesticide exposure.

Acetylcholinesterase modulates stress-induced motor responses through catalytic and noncatalytic properties.

RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons.

Adaptive changes in acetylcholinesterase gene expression as mediators of recovery from chemical and biological insults.

Neuromuscular therapeutics by RNA-targeted suppression of ACHE gene expression.

Readthrough acetylcholinesterase: a multifaceted inducer of stress reactions.

Impaired hippocampal plasticity and errors in cognitive performance in mice with maladaptive AChE splice site selection.

It is all about resolution. Meeting report based upon presentations at the 10th International Global BioMillennium 2006 symposium on molecular cell biology (Tbilisi, Georgia).

The thymic theme of acetylcholinesterase splice variants in myasthenia gravis.

A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress.

Readthrough acetylcholinesterase in inflammation-associated neuropathies.

Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath.

Translational control of recombinant human acetylcholinesterase accumulation in plants.

Peripheral site acetylcholinesterase blockade induces RACK1-associated neuronal remodeling.

Cholinergic status modulations in human volunteers under acute inflammation.

Cytokines and cholinergic signals co-modulate surgical stress-induced changes in mood and memory.

Changes in readthrough acetylcholinesterase expression modulate amyloid-beta pathology.

Acetylcholinesterase activity in veterans of the first Gulf War.

Introduction: cholinesterases, from molecular complexity to non-hydrolytic functions.

The role of the read through variant of acetylcholinesterase in anxiogenic effects of predator stress in mice.

Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats.

The structural basis of amyloid formation.

Identifying alternative hyper-splicing signatures in MG-thymoma by exon arrays.

Antisense treatment for myasthenia gravis: experience with monarsen.

Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions.

Advanced microarray analysis highlights modified neuro-immune signaling in nucleated blood cells from Parkinson's disease patients.

N-acetylcholinesterase-induced apoptosis in Alzheimer's disease.

Stress-induced alternative splicing modulations in brain and periphery: acetylcholinesterase as a case study.

A network-based method for predicting disease-causing genes.

Heterogeneous nuclear ribonucleoprotein G regulates splice site selection by binding to CC(A/C)-rich regions in pre-mRNA.

The butyrylcholinesterase K variant confers structurally derived risks for Alzheimer pathology.

Pro-apoptotic protein-protein interactions of the extended N-AChE terminus.

Changes in brain MicroRNAs contribute to cholinergic stress reactions.

Erythropoietin attenuates hyperoxia-induced oxidative stress in the developing rat brain.

MicroRNA-132 potentiates cholinergic anti-inflammatory signaling by targeting acetylcholinesterase.

Alanine-to-threonine substitutions and amyloid diseases: butyrylcholinesterase as a case study.

Acetylcholinesterase variants in Alzheimer's disease: from neuroprotection to programmed cell death.

Transgenic plants as a source for the bioscavenging enzyme, human butyrylcholinesterase.

Serum cholinesterase activities distinguish between stroke patients and controls and predict 12-month mortality.

Engineering DYRK1A overdosage yields Down syndrome-characteristic cortical splicing aberrations.

Butyrylcholinesterase interactions with amylin may protect pancreatic cells in metabolic syndrome.

Plant-derived human butyrylcholinesterase, but not an organophosphorous-compound hydrolyzing variant thereof, protects rodents against nerve agents.

Cholinesterase modulations in patients with acute bacterial meningitis.

Effects of physostigmine on microcirculatory alterations during experimental endotoxemia.

Similar cation channels mediate protection from cerebellar exitotoxicity by exercise and inheritance.

NeurimmiRs: microRNAs in the neuroimmune interface.

Letter by Shenhar-Tsarfaty et al regarding article, "Autonomic shift and increased susceptibility to infections after acute intracerebral hemorrhage".

Deep brain stimulation induces rapidly reversible transcript changes in Parkinson's leucocytes.

Cholinesterase-Targeting microRNAs Identified in silico Affect Specific Biological Processes.

Adaptive alternative splicing correlates with less environmental risk of parkinsonism.

Predictors for poststroke outcomes: the Tel Aviv Brain Acute Stroke Cohort (TABASCO) study protocol.

Nicotinic stimulation induces Tristetraprolin over-production and attenuates inflammation in muscle.

Exon arrays reveal alternative splicing aberrations in Parkinson's disease leukocytes.

Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.

Threshold-independent meta-analysis of Alzheimer's disease transcriptomes shows progressive changes in hippocampal functions, epigenetics and microRNA regulation.

Meta-analysis of genetic and environmental Parkinson's disease models reveals a common role of mitochondrial protection pathways.

Stressing hematopoiesis and immunity: an acetylcholinesterase window into nervous and immune system interactions.

Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice.

Acetylcholinesterase loosens the brain's cholinergic anti-inflammatory response and promotes epileptogenesis.

Fluoxetine induces vasodilatation of cerebral arterioles by co-modulating NO/muscarinic signalling.

Quantum dot labeling of butyrylcholinesterase maintains substrate and inhibitor interactions and cell adherence features.

Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis.

Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load.

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4.

Heterogeneous nuclear ribonucleoprotein A1 in health and neurodegenerative disease: From structural insights to post-transcriptional regulatory roles.

Further developments with antisense treatment for myasthenia gravis.

Acetylcholinesterase: old questions and new developments.

Statistically invalid classification of high throughput gene expression data.

MicroRNA-132 Modulates Cholinergic Signaling and Inflammation in Human Inflammatory Bowel Disease.

Small RNA sequencing-microarray analyses in Parkinson leukocytes reveal deep brain stimulation-induced splicing changes that classify brain region transcriptomes.