Robert Damoiseaux

Towards the generation of artificial O6-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues.

SRC family kinases: potential targets for the treatment of human cancer and leukemia.

PNA-encoded protease substrate microarrays.

Cell-based chemical genetic screen identifies damnacanthal as an inhibitor of HIV-1 Vpr induced cell death.

Mycophenolic acid is a potent inhibitor of angiogenesis.

Amiodarone and bepridil inhibit anthrax toxin entry into host cells.

The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression.

Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by dopamine receptor-mediated signaling pathways.

A high-throughput screening strategy identifies cardiotonic steroids as alternative splicing modulators.

Ion channel and toxin measurement using a high throughput lipid membrane platform.

Integrated chemical genomics reveals modifiers of survival in human embryonic stem cells.

Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.

Nonaminoglycoside compounds induce readthrough of nonsense mutations.

Discovery and structure-activity relationship analysis of Staphylococcus aureus sortase A inhibitors.

High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones.

Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping.

Integrated pathways for neutrophil recruitment and inflammation in leprosy.

A broad-spectrum antiviral targeting entry of enveloped viruses.

Substrate specificity of the TIM22 mitochondrial import pathway revealed with small molecule inhibitor of protein translocation.

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.

High-content screening for biofilm assays.

High-throughput screening of silver nanoparticle stability and bacterial inactivation in aquatic media: influence of specific ions.

Microfluidic image cytometry.

Stability, bioavailability, and bacterial toxicity of ZnO and iron-doped ZnO nanoparticles in aquatic media.

Metabolic imaging allows early prediction of response to vandetanib.

Self-organizing map analysis of toxicity-related cell signaling pathways for metal and metal oxide nanoparticles.

No time to lose--high throughput screening to assess nanomaterial safety.

Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials.

Differential expression of syndecan-1 mediates cationic nanoparticle toxicity in undifferentiated versus differentiated normal human bronchial epithelial cells.

High throughput screening of small molecule libraries for modifiers of radiation responses.

Seeing the light: luminescent reporter gene assays.

High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles.

A molecular screening approach to identify and characterize inhibitors of glioblastoma stem cells.

Synergistic bactericidal activity of Ag-TiO₂ nanoparticles in both light and dark conditions.

Genome-wide bacterial toxicity screening uncovers the mechanisms of toxicity of a cationic polystyrene nanomaterial.

Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.

Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.

Automated phenotype recognition for zebrafish embryo based in vivo high throughput toxicity screening of engineered nano-materials.

Quantitative detection of PfHRP2 in saliva of malaria patients in the Philippines.

Fluoxetine is a potent inhibitor of coxsackievirus replication.

Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal.

Size of TiO(2) nanoparticles influences their phototoxicity: an in vitro investigation.

Size influences the cytotoxicity of poly (lactic-co-glycolic acid) (PLGA) and titanium dioxide (TiO(2)) nanoparticles.

Genome-wide assessment in Escherichia coli reveals time-dependent nanotoxicity paradigms.

Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1.

Dantrolene enhances antisense-mediated exon skipping in human and mouse models of Duchenne muscular dystrophy.

High-throughput screening of small molecules identifies hepcidin antagonists.

A small molecule inhibitor of redox-regulated protein translocation into mitochondria.

A broadly applicable high-throughput screening strategy identifies new regulators of Dlg4 (Psd-95) alternative splicing.

A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene.

Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.

Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.

Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation.

UCLA's Molecular Screening Shared Resource: enhancing small molecule discovery with functional genomics and new technology.

Cytolethal distending toxins require components of the ER-associated degradation pathway for host cell entry.

Identification of small molecules that disrupt signaling between ABL and its positive regulator RIN1.

Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.

Adaptation of a Genetic Screen Reveals an Inhibitor for Mitochondrial Protein Import Component Tim44.

Direct quantification of gamma H2AX by cell-based high throughput screening for evaluation of genotoxicity of pesticides in a human thyroid cell lines.

Gα facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3-kinase-mediated activation in a RhoA-dependent manner.

High-Throughput Screening of a Luciferase Reporter of Gene Silencing on the Inactive X Chromosome.

Making It All Work: Functional Genomics and Reporter Gene Assays.

Reporter Gene Assays Using Transfectable Functional Genomics Libraries.

Reporter Gene Assays Using Viral Functional Genomics Libraries.

A scalable filtration method for high throughput screening based on cell deformability.

Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism.

Development of a high-throughput screen to identify small molecule enhancers of sarcospan for the treatment of Duchenne muscular dystrophy.

Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma.

High-throughput screening identifies modulators of sarcospan that stabilize muscle cells and exhibit activity in the mouse model of Duchenne muscular dystrophy.

Uncoupling interferon signaling and antigen presentation to overcome immunotherapy resistance due to JAK1 loss in melanoma.

Commercial immunoglobulin products contain cross-reactive but not neutralizing antibodies against SARS-CoV-2.

PSA-Targeted Alpha-, Beta-, and Positron-Emitting Immunotheranostics in Murine Prostate Cancer Models and Nonhuman Primates.

Antiviral drug screen identifies DNA-damage response inhibitor as potent blocker of SARS-CoV-2 replication.

Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells.