Stan B. Floresco

Prefrontal Cortical Gamma-Aminobutyric Acid Transmission and Cognitive Function: Drawing Links to Schizophrenia from Preclinical Research.

Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area.

Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission.

Electrophysiological interactions between striatal glutamatergic and dopaminergic systems.

Magnitude of dopamine release in medial prefrontal cortex predicts accuracy of memory on a delayed response task.

Multiple dopamine receptor subtypes in the medial prefrontal cortex of the rat regulate set-shifting.

Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia.

Amygdala-prefrontal cortical circuitry regulates effort-based decision making.

Dissociable roles for the nucleus accumbens core and shell in regulating set shifting.

Mesocortical dopamine modulation of executive functions: beyond working memory.

Systemic and local administration of estradiol into the prefrontal cortex or hippocampus differentially alters working memory.

Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.

Thalamic-prefrontal cortical-ventral striatal circuitry mediates dissociable components of strategy set shifting.

Dopaminergic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway.

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors.

Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.

Dopaminergic regulation of limbic-striatal interplay.

Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear.

Differential effects of inactivation of the orbitofrontal cortex on strategy set-shifting and reversal learning.

Inactivation of the medial prefrontal cortex of the rat impairs strategy set-shifting, but not reversal learning, using a novel, automated procedure.

Dopaminergic modulation of risk-based decision making.

Cortico-limbic-striatal circuits subserving different forms of cost-benefit decision making.

Neural circuits subserving behavioral flexibility and their relevance to schizophrenia.

Ventral striatal dopamine modulation of different forms of behavioral flexibility.

Disruptions in spatial working memory, but not short-term memory, induced by repeated ketamine exposure.

Perturbations in different forms of cost/benefit decision making induced by repeated amphetamine exposure.

Fundamental contribution by the basolateral amygdala to different forms of decision making.

Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.

Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers.

Prefrontal cortical contribution to risk-based decision making.

Regional specificity in dopamine signaling during reward-related learning (Commentary on Aragona et al.).

Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell.

Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues.

Abrupt transitions between prefrontal neural ensemble states accompany behavioral transitions during rule learning.

Differential effects of dopaminergic manipulations on risky choice.

Pharmacological enhancement of memory and executive functioning in laboratory animals.

Reducing prefrontal gamma-aminobutyric acid activity induces cognitive, behavioral, and dopaminergic abnormalities that resemble schizophrenia.

Contributions of the nucleus accumbens and its subregions to different aspects of risk-based decision making.

Blockade of NMDA GluN2B receptors selectively impairs behavioral flexibility but not initial discrimination learning.

Dissociable contributions by prefrontal D1 and D2 receptors to risk-based decision making.

Repeated amphetamine exposure disrupts dopaminergic modulation of amygdala-prefrontal circuitry and cognitive/emotional functioning.

Emerging, reemerging, and forgotten brain areas of the reward circuit: Notes from the 2010 Motivational Neural Networks conference.

Estradiol modulates effort-based decision making in female rats.

NMDA GluN2A and GluN2B receptors play separate roles in the induction of LTP and LTD in the amygdala and in the acquisition and extinction of conditioned fear.

Separate prefrontal-subcortical circuits mediate different components of risk-based decision making.

Measuring the construct of executive control in schizophrenia: defining and validating translational animal paradigms for discovery research.

Acute stress induces selective alterations in cost/benefit decision-making.

Selective involvement by the medial orbitofrontal cortex in biasing risky, but not impulsive, choice.

Dynamic fluctuations in dopamine efflux in the prefrontal cortex and nucleus accumbens during risk-based decision making.

Receptor-specific modulation of risk-based decision making by nucleus accumbens dopamine.

Prefrontal NMDA receptors and cognition: working 2B remembered.

Prefrontal dopamine and behavioral flexibility: shifting from an "inverted-U" toward a family of functions.

What's better for me? Fundamental role for lateral habenula in promoting subjective decision biases.

Sex differences in response to amphetamine in adult Long-Evans rats performing a delay-discounting task.

Chronic alcohol disrupts dopamine receptor activity and the cognitive function of the medial prefrontal cortex.

Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts.

Prefrontal cortical GABA transmission modulates discrimination and latent inhibition of conditioned fear: relevance for schizophrenia.

Adolescent alcohol exposure reduces behavioral flexibility, promotes disinhibition, and increases resistance to extinction of ethanol self-administration in adulthood.

Overriding phasic dopamine signals redirects action selection during risk/reward decision making.

The nucleus accumbens: an interface between cognition, emotion, and action.

Dopamine antagonism decreases willingness to expend physical, but not cognitive, effort: a comparison of two rodent cost/benefit decision-making tasks.

Dopaminergic circuitry and risk/reward decision making: implications for schizophrenia.

Prefrontal Cortical GABA Modulation of Spatial Reference and Working Memory.