Imaging and Quantification of the Hepatic Vasculature of Mice Using Ultrafast Doppler UltrasoundKaterina Stripling 1,2, Finn Timmermans 1,2, Sofiane Décombas-Deschamps 3, Jérémy H. Thalgott 1,2, David Lemonnier 1,2,3, Margreet R. de Vries 2,4,5, Ton J. Rabelink 1,2,6, Mickael Tanter 3, Thomas Deffieux 3, Franck Lebrin 1,2,3
1Department of Internal Medicine - Nephrology, Leiden University Medical Center, 2Einthoven Laboratory of Vascular and Regenerative Medicine, Leiden University Medical Center, 3Institute Physics for Medicine Paris, Inserm, ESPCI-Paris-PSL, 4Department of Surgery - Vascular surgery, Leiden University Medical Center, 5Department of Surgery, Brigham & Women's Hospital, Harvard Medical School, 6The Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), Leiden University Medical Center
Ultrafast Doppler ultrasound (UFUS) with high spatial resolution (100 mm) and sensitivity represents a suitable noninvasive imaging modality for obtaining a comprehensive qualitative overview of the hepatic vasculature. UFUS also facilitates quantitative measurements of the microvasculature, aiming to enhance our understanding of vascular disease mechanisms.
