Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In SituJesús Espada 1,2, Elisa Carrasco 3, María I. Calvo-Sánchez 1,4, Sandra Fernández-Martos 1, Juan José Montoya 5
1Ramón y Cajal Institute for Health Research (IRYCIS), Ramón y Cajal University Hospital, 2Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O'Higgins, 3Department of Molecular Biology, Faculty of Sciences, Universidad Autónoma de Madrid (UAM), 4Instituto de Investigaciones Biosanitarias, Facultad de Ciencias Experimentales, Universidad Francisco de Vitoria, 5Department of Radiology, Rehabilitation & Physiotherapy, Faculty of Medicine, Complutense University
The aim of this protocol is to induce transient in vivo production of nonlethal levels of reactive oxygen species (ROS) in mouse skin, further promoting physiological responses in the tissue.
