Rapid Isolation of Viable Circulating Tumor Cells from Patient Blood SamplesAndrew D. Hughes 1, Jeff Mattison 1, John D. Powderly 2,3, Bryan T. Greene 2,3, Michael R. King 1
1Department of Biomedical Engineering, Cornell University, 2BioCytics, Inc., 3Carolina BioOncology Institute, PLLC
Circulating tumor cells are isolated from the blood of cancer patients without inflicting cellular damage. Isolation of tumor cells is accomplished using a bimolecular surface of E-selectin in addition to antibodies against epithelial markers. A nanotube coating specifically promotes cancer cell adhesion resulting in high capture purities.
