Sensing of Barrier Tissue Disruption with an Organic Electrochemical TransistorScherrine A. Tria 1, Marc Ramuz 1, Leslie H. Jimison 2, Adel Hama 1, Roisin M. Owens 1
1Department of Bioelectronics, Ecole Nationale Superieure des Mines, 2Research and Exploratory Development Division, Applied Physics Laboratory, Johns Hopkins University
The Organic Electrochemical Transistor is integrated with live cells and used to monitor ion flux across the gastrointestinal epithelial barrier. In this study, an increase in ion flux, related to disruption of tight junctions, induced by the presence of the calcium chelator EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N',N'-tetra acetic acid), is measured.
