Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data GenerationVaibhav Shinde *1, Stefanie Klima *2, Perumal Srinivasan Sureshkumar 1, Kesavan Meganathan 1, Smita Jagtap 1, Eugen Rempel 3, Jörg Rahnenführer 3, Jan Georg Hengstler 4, Tanja Waldmann 2, Jürgen Hescheler 1, Marcel Leist *2, Agapios Sachinidis *1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
The protocols describe two in vitro developmental toxicity test systems (UKK and UKN1) based on human embryonic stem cells and transcriptome studies. The test systems predict human developmental toxicity hazard, and may contribute to reduce animal studies, costs and the time required for chemical safety testing.
