Carestream Molecular Imaging
2 ARTICLES PUBLISHED IN JoVE
Medicine
Segmentation and Measurement of Fat Volumes in Murine Obesity Models Using X-ray Computed Tomography
Todd A. Sasser 1, Sarah E. Chapman 2, Shengting Li 1, Caroline Hudson 2, Sean P. Orton 1, Justin M. Diener 3, Seth T. Gammon 1, Carlos Correcher 4, W. Matthew Leevy 2
1Carestream Molecular Imaging , 2Department of Chemistry and Biochemistry, University of Notre Dame , 3Freimann Life Science Center, University of Notre Dame , 4Research and Development, Oncovision, GEM-Imaging S.A.
Fat content analysis is routinely conducted in studies utilizing murine obesity models. Emerging methods in small animal CT imaging and analysis are providing for longitudinal detail rich fat content analysis. Here we detail step by step procedures for performing small animal CT imaging, analysis, and visualization.
Medicine
Murine Model for Non-invasive Imaging to Detect and Monitor Ovarian Cancer Recurrence
Natalia J. Sumi 1, Eydis Lima 1, John Pizzonia 2, Sean P. Orton 3, Vinicius Craveiro 1, Wonduk Joo 1, Jennie C. Holmberg 1, Marta Gurrea 1, Yang Yang-Hartwich 1, Ayesha Alvero 1, Gil Mor 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 2NatureMost Laboratories, 3Bruker Preclinical Imaging
We describe a non-invasive animal imaging platform that allows the detection, quantification, and monitoring of ovarian cancer growth and recurrence. This intra-peritoneal xenograft model mimics the clinical profile of patients with ovarian cancer.
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