Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human PrimatesLeah C Acker 1,2,3, Erica N. Pino 1,4,5, Edward S. Boyden 1,6,7, Robert Desimone 1,7
1McGovern Institute, Massachusetts Institute of Technology, 2Harvard-MIT Division of Heath Sciences and Technology, 3Department of Anesthesiology, Duke University Medical Center, 4Department of Biology, Massachusetts Institute of Technology, 5Division of Pharmacoengineering and Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, 6Media Lab and Department of Biological Engineering, Massachusetts Institute of Technology, 7Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology
A protocol to build a tissue penetrating illuminator for delivering light over large volumes with minimal diameter is presented.