S'identifier

Harvard Medical School, Beth Israel Deaconess Medical Center

2 ARTICLES PUBLISHED IN JoVE

Medicine

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs

Joshua J. Timmons¹, Sean Cohessy², Eric T. Wong¹

¹Brain Tumor Center & Neuro-Oncology Unit, Department of Neurology, Beth Israel Deaconess Medical Center & Harvard Medical School, ²Division of Cancer Genetics, Department of Medicine, Beth Israel Deaconess Medical Center & Harvard Medical School

Metastasis plays a profound role in the virulence of cancer, accounting for an estimated 90% of deaths. We report a protocol for a metastatic melanoma model in mice that is useful for determining the efficacy of therapeutic agents against this clinical phenomenon.

Cancer Research

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Mercedes M. Riley^1,2, Pyay San¹, Edwin Lok¹, Kenneth D. Swanson¹, Eric T. Wong¹

¹Brain Tumor Center and Neuro-Oncology Unit, Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, ²Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology

Glioblastoma is the most common and aggressive primary brain malignancy in adults, with most tumors recurring after initial treatment. Tumor Treating Fields (TTFields) therapy is the newest treatment modality for glioblastoma. Here, we describe the proper application of TTFields-transducer arrays on patients and discuss theory and aspects of treatment.