Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in CancerRebecca Smith 1, Kaylyn Devlin 1, David Kilburn 1, Sean Gross 1, Damir Sudar 2, Elmar Bucher 1, Michel Nederlof 2, Mark Dane 1, Joe W. Gray 1, Laura Heiser 1, James E. Korkola 1
1Department of Biomedical Engineering, Knight Cancer Institute, Oregon Health and Science University, 2Quantitative Imaging Systems LLC
The purpose of the method presented here is to show how microenvironment microarrays (MEMA) can be fabricated and used to interrogate the impact of thousands of simple combinatorial microenvironments on the phenotype of cultured cells.
