Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and AcetaminophenPreeti Sahay 1, Kshama Jain 1, Prakriti Sinha 1, Barun Das 1, Alaknanda Mishra 1, Ashwani Kesarwani 1, Parul Sahu 1, K. Varsha Mohan 1, M.J. Mahesh Kumar 2, Perumal Nagarajan 1, Pramod Upadhyay 1
1National Institute of Immunology, 2Center for Cellular and Molecular Biology
The acute liver failure animal model developed in the current study presents a feasible alternative for the study of potential therapies. The current model employs the combined effect of physical and drug-induced hepatic injury and provides a suitable time window to study the potential of novel therapies.
